Antibacterial and Antiparasitic Activity of Manganese(I) Tricarbonyl Complexes with Ketoconazole, Miconazole, and Clotrimazole Ligands

Simpson, Peter V.; Nagel, Christoph; Bruhn, Heike; Schatzschneider, Ulrich

doi:10.1021/acs.organomet.5b00458

Cited by 79 publications

(73 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to ruthenium, other organometallic complexes have also been reported to display interesting antiparasitic and/or anti-infective activities (29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42). For instance, one manganese(I) tricarbonyl complex, [Mn(CO) 3 (bpy R,R )(Ctz)]PF 6 (where bpy R,R is 2,2=-bipyridine), showed submicromolar activity against Staphylococcus aureus and Staphylococcus epidermidis with MICs of 0.625 M. Moreover, the related complex [Mn(CO) 3 (bpy R,R )(Ktz)]PF 6 (where Ktz is ketoconazole) was active against Trypanosoma brucei with an IC 50 of 0.7 M, while the IC 50 for mammalian cells was more than 10 times higher (43).…”

mentioning

confidence: 99%

Characterization of the Activities of Dinuclear Thiolato-Bridged Arene Ruthenium Complexes against Toxoplasma gondii

Basto

Müller

Rubbiani

et al. 2017

Antimicrob Agents Chemother

View full text Add to dashboard Cite

The effects of 18 dinuclear thiolato-bridged arene ruthenium complexes (1 monohiolato compound, 4 dithiolato compounds, and 13 trithiolato compounds), originally designed as anticancer agents, on the apicomplexan parasite grown in human foreskin fibroblast (HFF) host cells were studied. Some trithiolato compounds exhibited antiparasitic efficacy at concentrations of 250 nM and below. Among those, complex 1 and complex 2 inhibited proliferation with 50% inhibitory concentrations (ICs) of 34 and 62 nM, respectively, and they did not affect HFFs at dosages of 200 μM or above, resulting in selectivity indices of >23,000. The ICs of complex 9 were 1.2 nM for and above 5 μM for HFFs. Transmission electron microscopy detected ultrastructural alterations in the matrix of the parasite mitochondria at the early stages of treatment, followed by a more pronounced destruction of tachyzoites. However, none of the three compounds applied at 250 nM for 15 days was parasiticidal. By affinity chromatography using complex 9 coupled to epoxy-activated Sepharose followed by mass spectrometry, translation elongation factor 1α and two ribosomal proteins, RPS18 and RPL27, were identified to be potential binding proteins. In conclusion, organometallic ruthenium complexes exhibit promising activities against , and the potential mechanisms of action of these compounds as well as their prospective applications for the treatment of toxoplasmosis are discussed.

show abstract

mentioning

confidence: 99%

Characterization of the Activities of Dinuclear Thiolato-Bridged Arene Ruthenium Complexes against Toxoplasma gondii

Basto

Müller

Rubbiani

et al. 2017

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…It is evident that the tip of the iceberg has only barely been scratched when it comes to investigating the antimicrobial potential of metal complexes (Table 2). Although there have been in vitro studies into many other elements, including chromium [115], iron [116], manganese [117][118][119][120], copper [121], rhodium [122], palladium [123,124], and platinum [125], these were often preliminary in nature and require further validation [27,124,126]. While some metal complexes and metal ions have been shown to possess excellent antimicrobial activity, the question remains whether or not metals offer any significant advantages over purely organic compounds.…”

Section: Metal Complexes Vs Organic Moleculesmentioning

confidence: 99%

Metal Complexes, an Untapped Source of Antibiotic Potential?

2020

View full text Add to dashboard Cite

With the widespread rise of antimicrobial resistance, most traditional sources for new drug compounds have been explored intensively for new classes of antibiotics. Meanwhile, metal complexes have long had only a niche presence in the medicinal chemistry landscape, despite some compounds, such as the anticancer drug cisplatin, having had a profound impact and still being used extensively in cancer treatments today. Indeed, metal complexes have been largely ignored for antibiotic development. This is surprising as metal compounds have access to unique modes of action and exist in a wider range of three-dimensional geometries than purely organic compounds. These properties make them interesting starting points for the development of new drugs. In this perspective article, the encouraging work that has been done on antimicrobial metal complexes, mainly over the last decade, is highlighted. Promising metal complexes, their activity profiles, and possible modes of action are discussed and issues that remain to be addressed are emphasized.Antibiotics 2020, 9, 90 2 of 24 Metal-containing compounds have played a small but seminal role in medicinal chemistry of throughout the 20th century. An arsenic-containing compound, Salvarsan, was discovered at the beginning of the century and became the first effective treatment of syphilis [9]. It was however the discovery of the anticancer drug cisplatin and its successors that really kickstarted the field of inorganic medicinal chemistry. Even today, platinum-based chemotherapeutics are still used in the majority of cancer treatments [10]. The gold-containing auranofin is an approved drug for the treatment of rheumatoid arthritis and is currently under investigation for its anticancer as well as antimicrobial properties [11][12][13][14][15][16]. Invigorated by these breakthrough successes, the field has expanded to many other elements in the last few decades, with complexes of titanium, iron, ruthenium, gallium, palladium, silver, gold, bismuth, and copper entering clinical trials [17][18][19][20][21][22]. The medicinal applications of these metal complexes range from anticancer to antimalaria over to neurodegenerative diseases. Strangely, antibacterial applications are remarkably sparse in this list and the number of literature reports on metal-based antimicrobials is dwarfed by the much more frequent publications on metal-based anticancer compounds. This is surprising as metals such as bismuth and silver have long been known to possess antibacterial properties. Some medicinal products are currently available. There are however a variety of products, such as silver-coated underwear, with a more dubious scientific basis. Nevertheless, the systematic evaluation of the antimicrobial properties of metal complexes has increased in pace over the last decade, with several reports highlighting the activity and potential modes of action of metal-based antibiotics. This perspective article will discuss the major discoveries in the non-traditional field of metal complex-based antibiotic co...

show abstract

“…In this model, an Fe-30Mn group could be related to the effect of Mn release. Simpson et al [38] showed that coordination of Mn in tricarbonyl complexes drugs improve their biological activity. Also, another research on Mn-doped ZnO nanoparticles enhanced antibacterial activity compared to ZnO nanoparticles (NPs) [39].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Novel antibacterial biodegradable Fe-Mn-Ag alloys produced by mechanical alloying

Sotoudehbagha

Sheibani

Khakbiz

et al. 2018

Materials Science and Engineering: C

View full text Add to dashboard Cite

Various compositions and synthesis methods of biodegradable iron-based alloys have been studied aiming for the use of temporary medical implants. However, none is focused on nano-structured alloy and on adding antibacterial property to the alloy. In this study, new Fe-30Mn-(1-3)Ag alloys were synthesized by means of mechanical alloying and assessed for their microstructure, mechanical properties, corrosion rate, antibacterial activity and cytotoxicity. Results showed that the alloy with 3 wt% Ag content displayed the highest relative density, shear strength, micro hardness and corrosion rate. However, optimum cytotoxicity and the antibacterial activity were reached by the alloy with 1 wt% Ag content. The compositional and processing effects of the alloys' properties are further discussed in this work.

show abstract

Antibacterial and Antiparasitic Activity of Manganese(I) Tricarbonyl Complexes with Ketoconazole, Miconazole, and Clotrimazole Ligands

Cited by 79 publications

References 54 publications

Characterization of the Activities of Dinuclear Thiolato-Bridged Arene Ruthenium Complexes against Toxoplasma gondii

Characterization of the Activities of Dinuclear Thiolato-Bridged Arene Ruthenium Complexes against Toxoplasma gondii

Metal Complexes, an Untapped Source of Antibiotic Potential?

Novel antibacterial biodegradable Fe-Mn-Ag alloys produced by mechanical alloying

Contact Info

Product

Resources

About