Novel antibacterial biodegradable Fe-Mn-Ag alloys produced by mechanical alloying

Abstract

Various compositions and synthesis methods of biodegradable iron-based alloys have been studied aiming for the use of temporary medical implants. However, none is focused on nano-structured alloy and on adding antibacterial property to the alloy. In this study, new Fe-30Mn-(1-3)Ag alloys were synthesized by means of mechanical alloying and assessed for their microstructure, mechanical properties, corrosion rate, antibacterial activity and cytotoxicity. Results showed that the alloy with 3 wt% Ag content displayed the highest relative density, shear strength, micro hardness and corrosion rate. However, optimum cytotoxicity and the antibacterial activity were reached by the alloy with 1 wt% Ag content. The compositional and processing effects of the alloys' properties are further discussed in this work.

Design and characterization of nano and bimodal structured biodegradable Fe-Mn-Ag alloy with accelerated corrosion rate

“…Additional micro-(MS1A) and bimodal-structured (BM1A) samples of Fe-30Mn-1Ag were produced from unmilled powders and a mixture of 50% milled with 50% unmilled powders, respectively. The 1 wt.% Ag composition was selected based on the optimum cytotoxicity and antibacterial activity of Fe-30Mn-1Ag alloy proven in our previous study [25]. The chemical composition of the powders after mechanical alloying was measured by using carbon-sulfur analyzer (CS744 Leco, USA) and atomic absorption spectrophotometer (AAnalyst 100, Perkin Elmer, USA).…”

“…4a, 4b). In NS1A, a complete solid solution formed during 10 h of mechanical alloying [25]. While 100% of MS1A and 50% of BM1A were Crystallite size of the samples was calculated from the XRD patterns using Williamson-Hall method [33] and presented in Table 2 alongside with the results from the micro-hardness test.…”

Repair of alveolar cleft bone defects by bone collagen particles combined with human umbilical cord mesenchymal stem cells in rabbit

“…The results of the blood test showed that the bone collagen particles and hUC-MSCs had good biological safety, and that the hUC-MSCs could reduce the inflammatory response. We speculate that bone collagen particles and hUC-MSCs do not significantly change the physiological environment of the body in the absorption process like metal alloy materials [35][36][37].In addition, the main components of bone collagen particles are hydroxyapatite and collagen type I, which can effectively reduce its immunogenicity. The immunogenicity of hUC-MSCs is also relatively low [22].…”

Repair of alveolar cleft bone defects by bone collagen particles combined with human umbilical cord mesenchymal stem cells in rabbit

“…Here, the results of the blood test showed that the bone collagen particles and HUC-MSCs had good biocompatibility, and that the HUC-MSCs could reduce the inflammatory response. We speculated that bone collagen particles and HUC-MSCs do not significantly change the physiological environment of the body during absorption, similar to metal alloy materials [35][36][37]. In addition, the main components of bone collagen particles are hydroxyapatite and collagen type 1, which can effectively reduce its immunogenicity.…”