Antibacterial and Antioxidant Property of Streptomyces cinnamonensis VITNS1 Isolated from Serkadu Region, Vellore, Tamil Nadu, India

Subathradevi, C.; Devi, P. Nirmala; Jemimahnaine, S.; Mohanasrinivasan, V.

doi:10.2174/2211352512666140714175749

Cited by 3 publications

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“…Antioxidants react with DPPH, transfers proton and results in decolorization of radical (color change from purple to yellow). The degree of discoloration depends on the ability of antioxidant compound to donate hydrogen proton (Braca et al, 2001;Sharma and Bhat, 2009;Kekuda et al, 2010b;Sowndhararajan and Kang, 2013;Subathradevi et al, 2014;Lee et al, 2014). In this study, the absorbance of DPPH in the presence of various concentrations of solvent extracts of selected actinomycetes was measured at 517nm.…”

Section: Solvent Extracts Of Actinomycetes In Particularmentioning

confidence: 87%

“…Although the scavenging abilities of extracts were lesser than that of ascorbic acid, it was evident that the solvent extracts showed hydrogen donating ability and the extract could serve as free radical scavengers, acting possibly as primary antioxidants (Chung et al, 2006). Several other studies have also revealed the potential of actinomycetes to scavenge DPPH radicals (Sowndhararajan and Kang, 2013;Subathradevi et al, 2014;Lee et al, 2014).…”

Section: Solvent Extracts Of Actinomycetes In Particularmentioning

confidence: 96%

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Antimicrobial, Antioxidant and Cytotoxic Activity of <i>Streptomyces</i> species from Western Ghat Soils of Karnataka, India

Kekuda¹,

R²,

Gautham³

et al. 2016

Sci. Technol. Arts Res. J.

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Western Ghats of India represents one of the global biodiversity hotspots. The present study was carried out to isolate and determine antimicrobial, cytotoxic and antioxidant activity of actinomycetes from soils of different regions of Western Ghats of Shi Karnataka, India. A total of 182 isolates were recovered from 57 soil samples collected at 13 different regions of Western Ghat region of Shivamogga district by serial dilution technique. Out of 182 isolates, 17 isolates were chos determine antimicrobial, cytotoxic and antioxidant activity. Solvent extracts of these isolates exhibited varied antimicrobial potency against Gram positive and Gram negative bacteria, yeasts and molds. Ethyl acetate was found to be best solvent for extraction of bioactive metabolites from most of isolates followed by butanol and hexane. Cytotoxic activity, as evaluated by brine shrimp lethality bioassay, revealed the potency of extracts to cause dose dependent mortality of brine shrimp larvae. Solvent extracts exhibited dose dependent antioxidant activity, as evaluated by DPPH, ABTS, Metal chelating and Ferric reducing assays. Western Ghat actinomycetes appear to be promising resources of bioactive agents and can be exploited industrially. Further studies on recovery of active constituents from solvent extracts and their bioactivity determinations are to be carried out. Abstract Article InformationWestern Ghats of India represents one of the global biodiversity hotspots. The present study was carried out to isolate and determine antimicrobial, cytotoxic and antioxidant activity of actinomycetes from soils of different regions of Western Ghats of Shivamogga district, Karnataka, India. A total of 182 isolates were recovered from 57 soil samples collected at 13 different regions of Western Ghat region of Shivamogga district by serial dilution-plating technique. Out of 182 isolates, 17 isolates were chosen for solvent extraction and to determine antimicrobial, cytotoxic and antioxidant activity. Solvent extracts of these isolates exhibited varied antimicrobial potency against Gram positive and Gram negative bacteria, und to be best solvent for extraction of bioactive metabolites from most of isolates followed by butanol and hexane. Cytotoxic activity, as evaluated by brine shrimp lethality bioassay, revealed the potency of extracts to cause dose brine shrimp larvae. Solvent extracts exhibited dose dependent antioxidant activity, as evaluated by DPPH, ABTS, Metal chelating and Ferric reducing assays. Western Ghat actinomycetes appear to be promising resources of bioactive agents ed industrially. Further studies on recovery of active constituents from solvent extracts and their bioactivity determinations are to be carried out.

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Section: Solvent Extracts Of Actinomycetes In Particularmentioning

confidence: 87%

Section: Solvent Extracts Of Actinomycetes In Particularmentioning

confidence: 96%

Antimicrobial, Antioxidant and Cytotoxic Activity of <i>Streptomyces</i> species from Western Ghat Soils of Karnataka, India

Kekuda¹,

R²,

Gautham³

et al. 2016

Sci. Technol. Arts Res. J.

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Bentonite Clays for Therapeutic Purposes and Biomaterial Design

Srasra

Bekri-Abbes

2020

CPD

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Background: Bentonite is a natural clay composed mainly of montmorillonite with other associated minerals such as feldspar, calcite and quartz. Owing to its high cation exchange, large surface area and ability to form thixotropic gels with water and to absorb large quantities of gas, it presents a large medicinal application. Objective: This review focuses on the promising potential of bentonite clays for biomaterial design and for therapeutic purposes. Methods: PubMed, ACS publications and Elsevier were searched for relevant papers. We have also evaluated the references of some pertinent articles. Results: Healing properties of bentonite are derived from the crystalline structure of the smectite group, which is composed of two octahedral alumina sheets localized between two tetrahedral silica sheets. This structure is behind the ability to intercalate cationic bioactive agents and undergoes interaction with various toxic species and exchanging in return species such as Fe3+, Cu2+, Al3+ Ca2+ or Na+, presenting antibacterial activity and providing essential minerals to the body. Furthermore, due to to its layered structure, bentonite has wide application for the design of biomaterials providing, thus, the stability of bioactive agents and preventing them from aggregation. Conclusion: Numerous publications have cited bentonite extensive applications as an alternative and complementary treatment for numerous health conditions as a detoxifying agent and for the preparation of several bionanocomposites.

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Streptomyces-Derived Metabolites with Potential Photoprotective Properties—A Systematic Literature Review and Meta-Analysis on the Reported Chemodiversity

et al. 2020

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Sun overexposure is associated with the development of diseases that primarily affect the skin, which can lead to skin cancer. Among the main measures of photoprotection is the use of sunscreens. However, there is currently concern about the reported harmful effects to both humans and the environment due to several of the sunscreen ingredients available on the market. For this reason, the search for and development of new agents with photoprotective properties is required. In searching for these metabolites, researchers have turned their attention to microbial sources, especially the microbiota in unusual hostile environments. Among the diverse microorganisms available in nature, Actinobacteria and specifically Streptomyces, have been shown to be a source of metabolites with various biological activities of interest, such as antimicrobial, antitumor and immunomodulator activities. Herein, we present the results of a systematic review of the literature in which Streptomyces isolates were studied as a source of compounds with photoprotective properties. A meta-analysis of the structure-property and structure-activity relationships of those metabolites identified in the qualitative analysis phase was also carried out. These findings indicate that Streptomyces are a source of metabolites with potential applications in the development of new, safe and more eco-friendly sunscreens.

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Antibacterial and Antioxidant Property of Streptomyces cinnamonensis VITNS1 Isolated from Serkadu Region, Vellore, Tamil Nadu, India

Cited by 3 publications

References 0 publications

Antimicrobial, Antioxidant and Cytotoxic Activity of <i>Streptomyces</i> species from Western Ghat Soils of Karnataka, India

Antimicrobial, Antioxidant and Cytotoxic Activity of <i>Streptomyces</i> species from Western Ghat Soils of Karnataka, India

Bentonite Clays for Therapeutic Purposes and Biomaterial Design

Streptomyces-Derived Metabolites with Potential Photoprotective Properties—A Systematic Literature Review and Meta-Analysis on the Reported Chemodiversity

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