Antibacterial and antioxidant activity of methanol extract of Evolvulus nummularius

Pavithra, P; Sreevidya, N.; Verma, Rama Shanker

doi:10.4103/0253-7613.58514

Cited by 16 publications

(9 citation statements)

References 10 publications

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“…[ 30 ] Flavonoids are responsible for the free radical scavenging activity and are known to promote the wound healing process which is responsible for wound contraction and increased rate of epithelization. [ 31 ] Previous works, as well as preliminary studies in our laboratory show antioxidant property of silibinin. [ 32 ] Wounds are usually accompanied by pain as well as reddening and edema of the surrounding tissues.…”

Section: Discussionmentioning

confidence: 94%

Wound healing activity of silibinin in mice

Samanta¹,

Pattnaik²,

Pradhan³

et al. 2016

Phcog Res

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Background:Silibinin is a semi-purified fraction of silymarin contained in milk thistle (Silybum marianum Asteraceae). Primarily known for its hepatoprotective actions, silymarin may also stimulate epithelialization and reduce inflammation in excision wound. Previous studies show antioxidant, anti-inflammatory, and antimicrobial actions of silibinin. However, wound healing property of silibinin is not well studied.Objective:This study investigates wound healing activity of silibinin topical formulation.Materials and Methods:Wound healing activity of 0.2% silibinin gel was assessed by incision and excision wound models in mice. Animals were divided into gel base, silibinin gel, and Mega Heal gel® treated groups with six animals in each group. Wound contraction, wound tissue tensile strength, and hydroxyproline content were measured, and histopathological evaluation of wound tissue of all the above treatment groups was carried out.Results:Application of 0.2% silibinin hydrogel for 8 days led to 56.3% wound contraction compared to 64.6% using standard Mega Heal gel with a subsequent increase in hydroxyproline content, which was significantly higher (P < 0.001) over control animals showing 33.2% contraction. After 14 days, percentage of contraction reached 96.1%, 97.6%, and 86.7%, respectively. Wound tissue tensile strength with silibinin (223.55 ± 3.82 g) and standard (241.38 ± 2.49 g) was significantly higher (P < 0.001) than control (174.06 ± 5.75 g). Histopathology of silibinin and standard gel treated wound tissue showed more fibroblasts, fewer macrophage infiltration, and well-formed collagen fibers.Conclusion:Here, we show potent wound healing activity of silibinin hydrogel formulation.SUMMARY 0.2% silibinin hydrogel showed potent wound healing activity in incision and excision wound models in mice. Abbreviations Used: ROS: Reactive oxygen species

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Section: Discussionmentioning

confidence: 94%

Wound healing activity of silibinin in mice

Samanta¹,

Pattnaik²,

Pradhan³

et al. 2016

Phcog Res

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“…Confirmatory Testing (Magnesium Ribbon Test) [17] . Magnesium ribbon test is known because of the use of magnesium ribbon in the testing of flavonoids.…”

Section: Methodsmentioning

confidence: 99%

Antioxidant and Antibacterial Potential of Silver Nanoparticles: Biogenic Synthesis Utilizing Apple Extract

Nagaich

Gulati

Chauhan

2016

Journal of Pharmaceutics

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The advancement of the biological production of nanoparticles using herbal extracts performs a significant role in nanotechnology discipline as it is green and does not engage harsh chemicals. The objective of the present investigation was to extract flavonoids in the mode of apple extract and synthesize its silver nanoparticles and ultimately nanoparticles loading into hydrogels. The presence of flavonoids in apple extract was characterized by preliminary testing like dil. ammonia test and confirmatory test by magnesium ribbon test. The synthesized silver nanoparticles were characterized using UV spectroscopy, particle size and surface morphology, and zeta potential. Silver nanoparticles loaded hydrogels were evaluated for physical appearance, pH, viscosity, spreadability, porosity, in vitro release, ex vivo permeation, and antibacterial (E. coli and S. aureus) and antioxidant studies (DPPH radical scavenging assay). Well dispersed silver nanoparticles below were observed in scanning electron microscope image. Hydrogels displayed in vitro release of 98.01% ± 0.37% up to 24 h and ex vivo permeation of 98.81 ± 0.24% up to 24 h. Hydrogel effectively inhibited the growth of both microorganism indicating good antibacterial properties. The value of percent radical inhibition was 75.16% ± 0.04 revealing its high antioxidant properties. As an outcome, it can be concluded that antioxidant and antiageing traits of flavonoids in apple extract plus biocidal feature of silver nanoparticles can be synergistically and successfully utilized in the form of hydrogel.

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“…The higher antibacterial activities were in the extracts of Madhuca longifolia L., Parkia biglandulosa L., and Pterospermum acerifolium L. compared to the other plants screened. Pavithra et al screened Evolvulus nummularius L. for its antibacterial activity, finding that Escherichia coli and B. subtilis were the most inhibited by an ethanolic extract [ 129 ].…”

Section: Plants As An Antimicrobial Sourcementioning

confidence: 99%

“…Hygrophila spinosa Andres leaves showed significant antibacterial activity when collected between September to October, with less activity seen during other months [ 129 ]. Artemisia pallens L. has been studied for its antimicrobial activity against seven species of bacteria [ 130 ].…”

Section: Plants As An Antimicrobial Sourcementioning

confidence: 99%

Phytochemicals: Extraction, Isolation, and Identification of Bioactive Compounds from Plant Extracts

Altemimi

Lakhssassi

Baharlouei

et al. 2017

Plants

1,307

768

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There are concerns about using synthetic phenolic antioxidants such as butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA) as food additives because of the reported negative effects on human health. Thus, a replacement of these synthetics by antioxidant extractions from various foods has been proposed. More than 8000 different phenolic compounds have been characterized; fruits and vegetables are the prime sources of natural antioxidants. In order to extract, measure, and identify bioactive compounds from a wide variety of fruits and vegetables, researchers use multiple techniques and methods. This review includes a brief description of a wide range of different assays. The antioxidant, antimicrobial, and anticancer properties of phenolic natural products from fruits and vegetables are also discussed.

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Antibacterial and antioxidant activity of methanol extract of Evolvulus nummularius

Cited by 16 publications

References 10 publications

Wound healing activity of silibinin in mice

Wound healing activity of silibinin in mice

Antioxidant and Antibacterial Potential of Silver Nanoparticles: Biogenic Synthesis Utilizing Apple Extract

Phytochemicals: Extraction, Isolation, and Identification of Bioactive Compounds from Plant Extracts

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