Antibacterial and Antifungal Agents from Egyptian Marine Organisms

Badria, Farid A.; Guirguis, Adel N.; El-Naggar, Wael

doi:10.1076/phbi.35.4.284.13307

Cited by 18 publications

(8 citation statements)

References 5 publications

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“…There have been numerous studies, across the globe, reporting the bioactivities of marine-sourced organisms (e.g. Tziveleka et al 2003;Peters et al 2003;Yim et al 2004;Iken and Baker 2003;Tsoukatou et al 2002;Bhosale et al 2002;de Nys and Steinberg 2002;Pereira et al 2002;Wilsanand et al 2001;Armstrong et al 2000;Abarzua et al 1999;Ko¨nig et al 1999a;Siddhanta et al 1997;Badria et al 1997;Bernan et al 1997;Carte 1996;Sato 1996;Dhawan et al 1993;Sridhar and Vidyavathi 1991). Biogenic compounds belonging to several classes of marine micro-and macro-algae have been identified over the last few decades, and their chemical constitution and pharmacological activity have been studied in detail (e.g.…”

Section: Introductionmentioning

confidence: 98%

Exploitation of marine algae: biogenic compounds for potential antifouling applications

Bhadury

Wright

2004

Planta

281

171

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Marine algae are one of the largest producers of biomass in the marine environment. They produce a wide variety of chemically active metabolites in their surroundings, potentially as an aid to protect themselves against other settling organisms. These active metabolites, also known as biogenic compounds, produced by several species of marine macro- and micro-algae, have antibacterial, antialgal, antimacrofouling and antifungal properties, which are effective in the prevention of biofouling, and have other likely uses, e.g. in therapeutics. The isolated substances with potent antifouling activity belong to groups of fatty acids, lipopeptides, amides, alkaloids, terpenoids, lactones, pyrroles and steroids. These biogenic compounds have the potential to be produced commercially using metabolic engineering techniques. Therefore, isolation of biogenic compounds and determination of their structure could provide leads for future development of, for example, environmentally friendly antifouling paints. This paper mainly discusses the successes of such research, and the future applications in the context of understanding the systems biology of micro-algae and cyanobacteria.

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Section: Introductionmentioning

confidence: 98%

Exploitation of marine algae: biogenic compounds for potential antifouling applications

Bhadury

Wright

2004

Planta

281

171

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“…To date, around 30 species from this genus have been sampled and tested for bioactive secondary metabolites (Bie et al 2008). Extracts from these species displayed a plethora of interesting pharmacological properties (Anjaneyulu & Rao 1997), including HIV inhibition, neuroprotective activity, cytotoxicity, anti-inflammatory activity (Lin et al 2011a) and antimicrobial activity (Badria et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial effect of the red sea soft coral Sarcophyton trocheliophorum

Gomaa

Soliman

Ayesh

et al. 2015

Natural Product Research

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The marine soft corals Sarcophyton trocheliophorum crude extracts possessed antimicrobial activity towards pathogenic bacterial strains, i.e. Bacillus cereus, Salmonella typhi, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Bioassay-guided fractionation indicated that the antimicrobial effect was due to the presence of terpenoid bioactive derivatives. Further biological assays of the n-hexane fractions were carried out using turbidity assay, inhibition zone assay and minimum inhibitory concentration for investigating the growth-inhibition effect towards the Gram-positive and Gram-negative bacteria. The fractions were screened and the structure of the isolated compound was justified by interpretation of the spectroscopic data, mainly mass spectrometry (GC-MS). The structure was assigned as (5S)-3-[(3E,5S)-5-hydroxy-3-hepten-6-yn-1-yl]-5-methyl-2(5H)-furanone and was effective at concentrations as low as 0.20 mg/mL. The above findings, in the course of our ongoing research on marine products, may implicate that the profound anti-microbial activity of the S. trocheliophorum soft corals, inhabiting the red sea reefs, is attributed to the presence of growth-inhibiting secondary metabolites mainly terpenoids.

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“…Some of the typical terpenoids are known as chemical defense tools to protect soft corals against natural predators, as feeding deterrents or act by virtue of their toxicity [4,5,6]. From a pharmaceutical point of view, cembranoids have been reported to exhibit various biological activities, such as having antitumor, ichthyotoxic, antiinflammatory, neuroprotective, antibacterial, antiangiogenic, antimetastatic, and antiosteoporotic properties [7,8,9,10,11,12,13]. Soft corals, belonging to the genus Sarcophyton (Alcyoniidae), are well recognized as a rich source of macrocyclic cembrane-type diterpenoids and biscembranoids.…”

Section: Introductionmentioning

confidence: 99%

Sarcophyolides B–E, New Cembranoids from the Soft Coral Sarcophyton elegans

Bie

Chen

et al. 2013

Marine Drugs

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Four new cembrane-type diterpenoids, sarcophyolides B–E (1–4), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 1–4 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocrasol were found to exhibit potent inhibition against A2780 human ovarian tumor cells.

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Antibacterial and Antifungal Agents from Egyptian Marine Organisms

Cited by 18 publications

References 5 publications

Exploitation of marine algae: biogenic compounds for potential antifouling applications

Exploitation of marine algae: biogenic compounds for potential antifouling applications

Antibacterial effect of the red sea soft coral Sarcophyton trocheliophorum

Sarcophyolides B–E, New Cembranoids from the Soft Coral Sarcophyton elegans

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