Antibacterial and Antifungal Activities of the Constituents ofFlemingia paniculata.

Abstract

A salicylic acid derivative (1), a cinnamaldehyde (2), and six isoflavones (3-8) from the stem bark of Flemingia paniculata Wall. (Leguminosae) were tested for antibacterial (both Gram-positive and Gram-negative) and antifungal activities. All the compounds showed significant activities against the test organisms having MIC values in the range of 1.57-200 µg/mL. The highest potency (MIC = 1.57 µg/mL) was exhibited by 3 against Staphylococcus aureus.

Antibacterial activity of two limonoids from Swietenia mahagoni against multiple-drug-resistant (MDR) bacterial strains

“…Previous phytochemical investigations on this species led to isolation and identification of more than 45 limonoids belonging to the structural classes andirobin, gendunin, mexicanolide and phragmalin, triterpens, tetranortriterpenes, and chlorogenic acid [4,5,9,11,12]. As a part of our ongoing phytochemical and bioactivity studies on Bangladeshi plants [13][14][15][16][17][18], we now report on the isolation, identification, and antibacterial properties of two limonoids, swietenolide (1) and 2-hydroxy-3-O-tigloylswietenolide (2), the latter being a new natural product, from Swietenia mahagoni against a number of multiple-drug-resistant (MDR) bacterial strains.…”

First Total Synthesis of (±)‐Puyanin and (±)‐4′‐O‐Methylbonannione

“…Natural flavanones exist widely in the plant kingdom and exhibit many important biological and pharmacological activities such as antibacterial, 1,2 antifungal, 3 antitumor 4 and hypotensive. 5 Prenylated flavanones are a unique class of flavonoids characterized by the presence of a prenylated side chain (i.e.…”

Antimicrobial Secondary Metabolites—Extraction, Isolation, Identification, and Bioassay

“…The highest potency (MIC ¼ 1.57 mg/mL; 0.005 mmol) was exhibited by a new isoflavone, 5,7,4 0 -trihydroxy-8-(1,1-dimethylprop-2-enyl)-isoflavone (Figure 23.6), against S. aureus[70]. Its activity was counted as half of that of amoxycillin (MIC ¼ 0.89 mg/mL; 0.0024 mmol).…”