Antibacterial activity of two limonoids from Swietenia mahagoni against multiple-drug-resistant (MDR) bacterial strains

Abstract

Solvent partitioning followed by column chromatography of the MeOH extract of the seeds of Swietenia mahagoni afforded two limonoids, swietenolide (1) and 2-hydroxy-3-O-tigloylswietenolide (2). The compounds were identified by spectroscopic means. The antibacterial activity of these compounds was assessed against eight multiple-drug-resistant bacterial strains (clinical isolates) by the conventional disc diffusion method. While both compounds were active against all test organisms, compound 2 displayed overall more potent activity than compound 1.

Pharmacological effects and active phytoconstituents of Swietenia mahagoni: a review

“…The crude methanolic extract of seeds contains alkaloids, terpenoids, anthraquinones, cardiac glycosides, saponins, and volatile oils [14] . Two potent antimicrobial limonoids, swietenolide ( Figure 2) and 2-hydroxy-3-O-tigloylswietenolide (Figure 3), have been isolated from the methanolic extracts of the seed, and the structures of the compounds have been confirmed using spectroscopic analysis [15] . When the ether extract of the seed was systematically separated, 28 tetranotriterpenoids related to swietenine and swietenolide were found.…”

Composition of the Volatiles ofCitrus macropteravar.annamensisand Evaluation of Bioactivity

“…As part of our on-going studies on Bangladeshi medicinal plants [7][8][9][10][11][12][13][14][15][16][17][18][19][20] , we now report on the composition of the distilled peel volatile oil of the fruits of Citrus macroptera Mont. var.…”

Highly Oxygenated Flavonoids from the Leaves of Nicotiana plumbaginifolia (Solanaceae)

“…In continuation of phytochemical and bioactivity studies on Bangladeshi medicinal plants [1][2][3][4][5][6], we have investigated Nicotiana plumbaginifolia Viv. (Solanaceae).…”