Antibacterial and antifungal activities of new pyrazolo[3,4-d]pyridazin derivatives

Synthesis and characterization of some pyrazole derivatives of 1,5‐diphenyl‐1H‐pyrazole‐3,4‐dicarboxylic acid

“…On the other hand, cyclo‐condensation reaction of 2 and 5a with hydrazine hydrate gave the same product pyrazolo[3,4‐d]pyridazine‐4,7‐dione 14 [6, 26]. IR, 1 H NMR, and 13 C NMR spectra [IR: 3158–2629), 1 H NMR: 10.40 (br.…”

“…The chemistry of pyrazole derivatives have been the subject of much research because of their importance in various applications and their widespread potential biological and pharmacological activities such as antimicrobial, antiviral, antitumor, anti‐inflammatory, pesticidal, antifungal, antidepressant, antipyretic, and analgesic [1–10]. Thus, these compounds have been the focus of high attention among medicinal chemists [11–16].…”

<i>In vitro</i> Anti Leukemia Cancer Activity of Some Novel Pyrazole Derivatives and Pyrazoles Containing Thiazole Moiety

“…Thiazoles are a familiar group of heterocyclic compounds possessing a wide variety of biological activities such as antimicrobial [24], antioxidant [25], antitubercular [26], anticonvulsant [27], anticancer [28][29][30][31][32][33][34], antiallergic [12] and anti-inflammatory [35,36] agents.…”

Synthesis of Polysubstituted Pyrazolo[3,4‐b]pyridine‐3‐Carbohydrazide and Pyrazolo[3,4‐d]pyridazine Derivatives

“…Pyrazolopyridines are promising candidates because of their significant use in treatment of brain disorders , coronary heart diseases , and viral diseases . Pyrazolo[3,4‐ d ]pyridazine derivatives show antibacterial and antifungal activities .…”

“…Pyrazolopyridines are promising candidates because of their significant use in treatment of brain disorders [18], coronary heart diseases [19], and viral diseases [20]. Pyrazolo[3, 4-d]pyridazine derivatives show antibacterial and antifungal activities [21]. C 5 -Amino and C 4 -formyl functional groups on pyrazole nucleus facilitate the synthesis of a variety of active heterocycles.…”