Antibacterial and antibiofilm properties of graphene and its derivatives

Cao, Guihua; Yan, Jining; Ning, Xiaoxuan; Qi, Zhang; Wu, Qi; Bi, Long; Zhang, Yumin; Han, Yisheng; Guo, Jianbin

doi:10.1016/j.colsurfb.2021.111588

Cited by 63 publications

(57 citation statements)

References 183 publications

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“…A number of studies have demonstrated the biocompatibility of graphene through in vitro cell co-culture and in vivo metabolic analysis, however, this observation is accompanied by qualifying conditions ( Alaghmandfard et al, 2021 ). The physical and chemical properties have been proved to greatly affect the interaction of graphene with living cells, and that the dose and concentration of graphene in the matrix are also related to its cytotoxicity ( Cao et al, 2021 ; Pulingam et al, 2021 ). The resulting cytotoxic effects occur mainly at the cellular and molecular levels and may be attributed to increased oxidative stress ( Sasidharan et al, 2016 ).…”

Section: Advantages Of Graphene In Bone Tissue Engineeringmentioning

confidence: 99%

Graphene and its Derivatives for Bone Tissue Engineering: In Vitro and In Vivo Evaluation of Graphene-Based Scaffolds, Membranes and Coatings

Jin

Liu

et al. 2021

Front. Bioeng. Biotechnol.

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Bone regeneration or replacement has been proved to be one of the most effective methods available for the treatment of bone defects caused by different musculoskeletal disorders. However, the great contradiction between the large demand for clinical therapies and the insufficiency and deficiency of natural bone grafts has led to an urgent need for the development of synthetic bone graft substitutes. Bone tissue engineering has shown great potential in the construction of desired bone grafts, despite the many challenges that remain to be faced before safe and reliable clinical applications can be achieved. Graphene, with outstanding physical, chemical and biological properties, is considered a highly promising material for ideal bone regeneration and has attracted broad attention. In this review, we provide an introduction to the properties of graphene and its derivatives. In addition, based on the analysis of bone regeneration processes, interesting findings of graphene-based materials in bone regenerative medicine are analyzed, with special emphasis on their applications as scaffolds, membranes, and coatings in bone tissue engineering. Finally, the advantages, challenges, and future prospects of their application in bone regenerative medicine are discussed.

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Section: Advantages Of Graphene In Bone Tissue Engineeringmentioning

confidence: 99%

Graphene and its Derivatives for Bone Tissue Engineering: In Vitro and In Vivo Evaluation of Graphene-Based Scaffolds, Membranes and Coatings

Jin

Liu

et al. 2021

Front. Bioeng. Biotechnol.

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“…RGO not only actuates rapid delivery of copper ions and massive assembly onto bacterial cells, but also leads to a shift of the copper ions valence from Cu 2+ into Cu + , which greatly enhances the antibacterial activity. Cao et al [ 53 ] reviewed the antibacterial and antibiofilm abilities of graphene and its derivatives in solution and on the surface, as well as their toxicity and possible mechanisms.…”

Section: Antimicrobial Activity and Applications Of Graphene Nanomaterialsmentioning

confidence: 99%

“…In this way, the study of Qiu et al [ 119 ] experimentally confirms the antibacterial mechanisms of GO/metal synergistic systems with an effect on nonoxidative electron transfer and ROS-mediated oxidative stress. Antibacterial and antibiofilm abilities of Gr and its derivatives in solution and on the surface were reviewed by Cao et al [ 53 ], in the sense of some controversy as to whether graphene and its derivatives can resist infections and biofilms. The not-fully-understood antibacterial mechanisms and cytotoxicity of Gr, as well as of its derivatives, are also in the frame of this review.…”

Section: Proposed Mechanisms Of Microbial Adhesion Inhibition By Graphene-based Nanomaterialsmentioning

confidence: 99%

Antibiofouling Activity of Graphene Materials and Graphene-Based Antimicrobial Coatings

et al. 2021

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Microbial adhesion and biofilm formation is a common, nondesirable phenomenon at any living or nonliving material surface in contact with microbial species. Despite the enormous efforts made so far, the protection of material surfaces against microbial adhesion and biofilm formation remains a significant challenge. Deposition of antimicrobial coatings is one approach to mitigate the problem. Examples of such are those based on heparin, cationic polymers, antimicrobial peptides, drug-delivering systems, and other coatings, each one with its advantages and shortcomings. The increasing microbial resistance to the conventional antimicrobial treatments leads to an increasing necessity for new antimicrobial agents, among which is a variety of carbon nanomaterials. The current review paper presents the last 5 years’ progress in the development of graphene antimicrobial materials and graphene-based antimicrobial coatings that are among the most studied. Brief information about the significance of the biofouling, as well as the general mode of development and composition of microbial biofilms, are included. Preparation, antibacterial activity, and bactericidal mechanisms of new graphene materials, deposition techniques, characterization, and parameters influencing the biological activity of graphene-based coatings are focused upon. It is expected that this review will raise some ideas for perfecting the composition, structure, antimicrobial activity, and deposition techniques of graphene materials and coatings in order to provide better antimicrobial protection of medical devices.

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“…36 Infections are a catastrophic complication in orthopedics and stomatology and are more difficult to manage due to the use of implant components. 37 Mechanisms for bacterial adhesion, aggregation and biofilm formation on biomaterials include van der Waals, electrostatic, hydrophobic and glycoprotein-mediated forces, etc. 37,38 Therefore, the development of materials that reduce the adhesion of pathogenic bacteria to the surface of the prosthesis and the formation of biofilms is fundamental to the reduction of periprosthetic infections.…”

Section: Discussionmentioning

confidence: 99%

“…37 Mechanisms for bacterial adhesion, aggregation and biofilm formation on biomaterials include van der Waals, electrostatic, hydrophobic and glycoprotein-mediated forces, etc. 37,38 Therefore, the development of materials that reduce the adhesion of pathogenic bacteria to the surface of the prosthesis and the formation of biofilms is fundamental to the reduction of periprosthetic infections. 39,40 In recent years, a growing number of researchers have begun coating artificial implants to prevent infection.…”

Section: Discussionmentioning

confidence: 99%

Coating CoCrMo Alloy with Graphene Oxide and ϵ-Poly-L-Lysine Enhances Its Antibacterial and Antibiofilm Properties

Guo¹,

Cao²,

Wang³

et al. 2021

IJN

Self Cite

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Introduction:With increases in implant infections, the search for antibacterial and biofilm coatings has become a new interest for orthopaedists and dentists. In recent years, graphene oxide (GO) has been extensively studied for its superior antibacterial properties. However, most of these studies have focused on solutions and there are few antibacterial studies on metal surfaces, especially the surfaces of cobalt-chromium-molybdenum (CoCrMo) alloys. ε-Poly -L-lysine (ε-PLL), as a novel food preservative, has a spectrum of antimicrobial activity; however, its antimicrobial activity after coating an implant surface is not clear. Methods: In this study, for the first time, a two-step electrodeposition method was used to coat GO and ε-PLL on the surface of a CoCrMo alloy. Its antibacterial and antibiofilm properties against S. aureus and E. coli were then studied. Results:The results show that the formation of bacteria and biofilms on the coating surface was significantly inhibited, GO and ε-PLL composite coatings had the best antibacterial and antibiofilm effects, followed by ε-PLL and GO coatings. In terms of classification, the coatings are antiadhesive and contact-killing/inhibitory surfaces. In addition to oxidative stress, physical damage to GO and electrostatic osmosis of ε-PLL are the main antibacterial and antibiofilm mechanisms. Discussion: This is the first study that GO and ε-PLL coatings were successfully prepared on the surface of CoCrMo alloy by electrodeposition. It provides a promising new approach to the problem of implant infection in orthopedics and stomatology.

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Antibacterial and antibiofilm properties of graphene and its derivatives

Cited by 63 publications

References 183 publications

Graphene and its Derivatives for Bone Tissue Engineering: In Vitro and In Vivo Evaluation of Graphene-Based Scaffolds, Membranes and Coatings

Graphene and its Derivatives for Bone Tissue Engineering: In Vitro and In Vivo Evaluation of Graphene-Based Scaffolds, Membranes and Coatings

Antibiofouling Activity of Graphene Materials and Graphene-Based Antimicrobial Coatings

Coating CoCrMo Alloy with Graphene Oxide and ϵ-Poly-L-Lysine Enhances Its Antibacterial and Antibiofilm Properties

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