Antibacterial and anti-adhesive properties of ionic liquids with various cationic and anionic heads toward pathogenic bacteria

Anvari, Sanam; Hajfarajollah, Hamidreza; Mokhtarani, Babak; Enayati, Mobin; Sharifi, Ali; Mirzaei, Mojtaba

doi:10.1016/j.molliq.2016.05.093

Cited by 55 publications

(38 citation statements)

References 30 publications

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“…Conversely, results for Gram-negative bacteria were less promising with a higher MIC and IC 50 values. However, these results are consistent with the ones reported about the natural resistance of Gram-negative bacteria to ILs [ 25 , 29 , 32 , 33 ]. Gram-negative bacteria resistance is expressed by multiple factors affecting not only the ILs but also the antibiotics used for the treatment of infections [ 34 ].…”

Section: Discussionsupporting

confidence: 93%

“…Results obtained for Gram-positive bacteria are promising since the bacterial viability IC 50 was about 25–140 μM; being lower than that reported by other authors [ 25 , 29 , 32 ]. Conversely, results for Gram-negative bacteria were less promising with a higher MIC and IC 50 values.…”

Section: Discussionmentioning

confidence: 54%

“…Antibacterial screening against the Gram-positive cocaceae is similar to other salts derived from imidazole. Studies were carried out using ILs with structural similarity than those from Anvari et al, who described an antibacterial activity with inhibition halos over 20 mm for S. aureus and E. coli [ 25 ]. Busetti et al reported antibacterial activities of 1-alkyl-quinoline ([Cnquin]Br), a structure-like IL similar to derivatives of N -acetylimidazole with chain lengths of 8, 10, 12, 14, 16 and 18 carbons, indicates that the chain length increasing would also increase the antimicrobial activity [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

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Novel Alkylimidazolium Ionic Liquids as an Antibacterial Alternative to Pathogens of the Skin and Soft Tissue Infections

et al. 2018

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Keeping in mind the concept of green chemistry, this research aims to synthesize and characterize new ionic liquids (ILs) derived from N-cinnamyl imidazole with different sizes of alkyl chains (1, 6, 8, and 10 carbon atoms), and evaluate their antibacterial activity against Skin and soft tissue infections (SSTIs) causative bacteria. The antibacterial screening was carried out by agar well diffusion and the Minimum Inhibitory Concentration (MIC) and Half Maximum Inhibitory Concentration (IC50) of the different ILs were determined by microdilution in broth, also Molecular dynamics simulations were performed to study the interaction mechanism between ILs and membranes. The MIC value in Gram-positive bacteria showed that as the hydrocarbon chain increases, the MIC value decreases with a dose-dependent effect. Furthermore, Gram-negative bacteria showed high MIC values, which were also evidenced in the antibacterial screening. The molecular dynamics showed an incorporation of the ILs with the longer chain (10 C), corresponding to a passive diffusion towards the membrane surface, for its part, the ILs with the shorter chain due to its lack of hydrophobicity was not incorporated into the bilayer. Finally, the new ILs synthesized could be an alternative for the treatment of Gram-positive bacteria causative of SSTIs.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

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Novel Alkylimidazolium Ionic Liquids as an Antibacterial Alternative to Pathogens of the Skin and Soft Tissue Infections

et al. 2018

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“…Other combination of these groups like glycolipopeptide and lipopolysaccharide also exist. Among them, rhamnolipids (as glycolipid) and surfactin (as lipopeptide) produced, respectively, by Pseudomonas aeruginosa and Bacillus subtilis are the most significant biosurfactants that have been extensively studied . The microbial origin of biosurfactants is bacteria, yeast, or fungi.…”

Section: Introductionmentioning

confidence: 99%

Biosurfactants from probiotic bacteria: A review

Hajfarajollah

Eslami

Mokhtarani

et al. 2018

Biotech and App Biochem

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Among microorganisms, bacteria are the main group of biosurfactant-producing organisms. Different types of bacteria including Pseudomonas sp., Acinetobacter sp., Bacillus sp., and Arthrobacter sp. are among the most commonly studied bacteria in the realm of scientific research. However, due to the pathogenic nature of the producing organisms, the application of these compounds is restricted, therefore, not suitable for use in food-related industries. Given that probiotic bacteria impact human health, applying probiotics as nonpathogenic and safe organisms have gained much attention for the production of biosurfactants in recent years. Most biosurfactants obtained from probiotic bacteria are related to a number of lactic acid bacteria (LAB). These types of biosurfactants are classified based on their structures as protein-carbohydrate complexes, lipids, or fatty acids. The present paper seeks to provide comprehensive and useful information about the production of various kinds of biosurfactants by different probiotic bacteria. In addition, we have extensively reviewed their potential for possible future applications.

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“…Furthermore, strong antimicrobial activity has been reported for imidazolium‐based ionic liquids, mainly due to the alkyl chain length in the cation. Actually, imidazolium salts comprising long alkyl chains (11–16 methylene groups) easily interact with bacteria cell membrane affecting its permeability with consequent cell death 24,25 …”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization, and antimicrobial activity of ferrocene‐containing polymeric materials

Zampino

Pedotti

Ussia

et al. 2020

J of Applied Polymer Sci

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Ferrocenyl(benzyl) imidazole (FcIm) and two related methyl‐imidazolium salts (FcMIm+I– and FcMIm+PF6–) were synthesized for their incorporation into plasticized PVC by solvent casting technique. The obtained materials were investigated for their thermal stability and, compared to pure polymer, films containing ionic ferrocene derivatives in 0.5% w/w loading were found slightly more stable. The pure ferrocene compounds showed antibacterial activity against Staphylococcus epidermis, but not against Escherichia coli, with a maximum for FcMIm+PF6– salt. After incorporation into PVC polymer, antibacterial activity against S. epidermis was observed (by disk diffusion test) only for PVC/FcMIm+PF6– (5% w/w) film, from which a release of 14.6% of the ferrocenilimidazolium cation in aqueous medium was measured after 24 hr.

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Antibacterial and anti-adhesive properties of ionic liquids with various cationic and anionic heads toward pathogenic bacteria

Cited by 55 publications

References 30 publications

Novel Alkylimidazolium Ionic Liquids as an Antibacterial Alternative to Pathogens of the Skin and Soft Tissue Infections

Novel Alkylimidazolium Ionic Liquids as an Antibacterial Alternative to Pathogens of the Skin and Soft Tissue Infections

Biosurfactants from probiotic bacteria: A review

Preparation, characterization, and antimicrobial activity of ferrocene‐containing polymeric materials

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