Antibacterial Alkaloids in Crinum jagus

Antibacterial activity of crinane alkaloids from Boophone disticha (Amaryllidaceae)

“…The similar antibacterial activity profiles of 1 and 2 may relate directly to their close structural proximity, the apparent difference being the shift of the double bond to C-2, C-3 and oxidation at C-1 in distichamine 2. Previous findings have shown that the ␣-crinane compound crinamine, which bears a close structural resemblance to buphanidrine and distichamine, as well as lycorine, exhibited antibacterial properties (Adesanya et al, 1992;Tan et al, 2011). In contrast to the present findings, it was earlier reported that both organic and aqueous extracts of Boophone disticha were inactive against the above four pathogens (Rabe and Van Staden, 1997).…”

Choline esterase inhibitory properties of alkaloids from two Nigerian Crinum species

“…It therefore appeared logical to test extracts for AChE inhibitory activity. Crinum species are known to produce alkaloids such as hamayne (Adesanya et al, 1992) but few of these compounds have been tested for their biological effects. …”

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“…On the other hand, lycorine, hamayne and 6-hydroxycrinamine were found to be inactive. Neither the extract nor the isolated alkaloids possessed any antifungal activity 96 . Crinamine and lycorine showed also activity against Bacillus cereus and Pseudomonas aeruginosa 60 .…”