Antibacterial agents that inhibit two-component signal transduction systems

Barrett, John; Goldschmidt, Raúl; Lawrence, Laura; Foleno, Barbara D.; Chen, R.; Demers, James P.; Johnson, Steven M.; Kanojia, Ramesh M.; Fernández, José A.; Bernstein, Jeffrey I.; Licata, Lisa; Donetz, A.; Huang, Shaoming; Hlasta, Dennis J.; Macielag, Mark J.; Ohemeng, Kwasi A.; Frechette, R. F.; Frosco, M. B.; Klaubert, Dieter H.; Whiteley, John M.; Wang, L.; Hoch, James A.

doi:10.1073/pnas.95.9.5317

Cited by 111 publications

(76 citation statements)

References 39 publications

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“…The high degree of conservation among two-component systems has made them an attractive target for novel classes of antimicrobial agents (3). Although two-component systems constitute one of the largest known families of transcriptional regulators in bacteria, few have been shown to be essential for cell viability.…”

mentioning

confidence: 99%

Crystal Structure of the Response Regulator 02 Receiver Domain, the Essential YycF Two-Component System ofStreptococcus pneumoniaein both Complexed and Native States

Bent¹,

Isaacs²,

Mitchell

et al. 2004

J Bacteriol

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mentioning

confidence: 99%

Crystal Structure of the Response Regulator 02 Receiver Domain, the Essential YycF Two-Component System ofStreptococcus pneumoniaein both Complexed and Native States

Bent¹,

Isaacs²,

Mitchell

et al. 2004

J Bacteriol

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“…RWJ-49815, an inhibitor of nonessential HK, which is involved in regulating the sporulation in B. subtilis, has shown wide-spectrum antimicrobial activity. 23) Our results suggest that Art1 could be the lead compound for a novel class of antibiotics. For the purpose of developing potent and useful antibiotics, it is important to evaluate the specificity of Art1 and its derivatives against various HKs, especially against essential HKs.…”

Section: Biological Activitymentioning

confidence: 95%

Articulosporasp. Produces Art1, an Inhibitor of Bacterial Histidine Kinase

Sugahara¹,

Kondo²,

Okada³

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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“…Previous screens for inhibitors of bacterial TCST pathways have been based on detection of the autophosphorylated HK protein or the phosphorylated RR protein (71)(72)(73)(74). Of the inhibitors identified in this way, some failed to inhibit growth of microbial test strains (74), and others were found to be inadequate due to lack of specificity (75).…”

Section: Prospects For Ypd1 As An Antifungal Drug Targetmentioning

confidence: 99%

Histidine Phosphotransfer Proteins in Fungal Two-Component Signal Transduction Pathways

Fassler

West

2013

Eukaryot Cell

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bThe histidine phosphotransfer (HPt) protein Ypd1 is an important participant in the Saccharomyces cerevisiae multistep twocomponent signal transduction pathway and, unlike the expanded histidine kinase gene family, is encoded by a single gene in nearly all model and pathogenic fungi. Ypd1 is essential for viability in both S. cerevisiae and in Cryptococcus neoformans. These and other aspects of Ypd1 biology, combined with the availability of structural and mutational data in S. cerevisiae, suggest that the essential interactions between Ypd1 and response regulator domains would be a good target for antifungal drug development. The goal of this minireview is to summarize the wealth of data on S. cerevisiae Ypd1 and to consider the potential benefits of conducting related studies in pathogenic fungi.

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Antibacterial agents that inhibit two-component signal transduction systems

Cited by 111 publications

References 39 publications

Crystal Structure of the Response Regulator 02 Receiver Domain, the Essential YycF Two-Component System ofStreptococcus pneumoniaein both Complexed and Native States

Crystal Structure of the Response Regulator 02 Receiver Domain, the Essential YycF Two-Component System ofStreptococcus pneumoniaein both Complexed and Native States

Articulosporasp. Produces Art1, an Inhibitor of Bacterial Histidine Kinase

Histidine Phosphotransfer Proteins in Fungal Two-Component Signal Transduction Pathways

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