<i>Articulospora</i>sp. Produces Art1, an Inhibitor of Bacterial Histidine Kinase

Sugahara, Hirosuke; Kondo, Toshiyuki; Okada, Masahiro; Ikeda, Yasuya; Kaida, Kenichi; Fudou, Ryosuke; Mizuno, Takeshi; Sakagami, Youji

doi:10.1271/bbb.80021

Cited by 8 publications

(7 citation statements)

References 22 publications

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“…We found a total of 54 differentially abundant taxonomic taxa. Most of the taxa present in the peel tissues of bagged apple fruit, such as the genera Articulospora [ 100 ], Bullera [ 78 ], Dioszegia [ 101 ], Erythrobasidium [ 102 ], and Sporobolomyces [ 82 , 102 ], have been reported to exhibit antifungal activity or growth-promoting activity, whereas the genus Taphrina has been reported to play an essential role as a pathogenic fungus, for example, T. deformans is the causative agent of peach leaf curl [ 103 , 104 ]. In addition, Dothideomycetes (particularly Pleosporaceae) were revealed as the most abundant biomarker in peel tissues.…”

Section: Discussionmentioning

confidence: 99%

“…C. laurentii , the predominant species, has been reported to be capable of enhancing plant growth as a biofertilizer for plants in nature [ 121 ]. Moreover, many fungal species in other classes (e.g., Eurotiomycetes and Leotiomycete) and families (e.g., Cordycipitaceae, Didymosphaeriaceae) have also been reported to play an important role as biological control agents [ 100 , 122 , 123 , 124 ]; at the same time, some of them have also been reported to show function as pathogenic fungi [ 125 , 126 , 127 , 128 ]. In addition, approximately 18% of the taxonomic clades of the total biomarkers were shown in the LDA histogram ( Figure 7 a) that were not assigned to any known taxa.…”

Section: Discussionmentioning

confidence: 99%

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Variations in the Community Structure of Fungal Microbiota Associated with Apple Fruit Shaped by Fruit Bagging-Based Practice

Khwantongyim

Wansee

et al. 2021

JoF

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The various fungal communities that adhere to apple fruit are influenced by agricultural practices. However, the effects of fruit bagging-based management practice on the fungal microbiota are still unknown, and little is known about the fungal communities of bagged apple fruit. We conducted a study using apple fruit grown in a conventionally managed orchard where pesticide use is an indispensable practice. Fungal communities were collected from the calyx-end and peel tissues of bagged and unbagged fruit and characterized using barcode-type next-generation sequencing. Fruit bagging had a stronger effect on fungal richness, abundance, and diversity of the fungal microbiota in comparison to non-bagging. In addition, bagging also impacted the compositional variation of the fungal communities inhabiting each fruit part. We observed that fruit bagging had a tendency to maintain ecological equilibrium since Ascomycota and Basidiomycota were more distributed in bagged fruit than in unbagged fruit. These fungal communities consist of beneficial fungi rather than potentially harmful fungi. Approximately 50 dominant taxa were detected in bagged fruit, for example, beneficial genera such as Articulospora, Bullera, Cryptococcus, Dioszegia, Erythrobasidium, and Sporobolomyces, as well as pathogenic genera such as Aureobasidium and Taphrina. These results suggested that fruit bagging could significantly increase fungal richness and promote healthy fungal communities, especially the harmless fungal communities, which might be helpful for protecting fruit from the effects of pathogens. This study provides a foundation for understanding the impacts of bagging-based practice on the associated fungal microbiota.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Variations in the Community Structure of Fungal Microbiota Associated with Apple Fruit Shaped by Fruit Bagging-Based Practice

Khwantongyim

Wansee

et al. 2021

JoF

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“…4,5,7-Trihydroxy-3-(1-oxodecyl)-2-naphthaleneacetic acid ( 270 ) isolated from an acetone extract of solid cultures of the aquatic hypomycete Articulospora sp. inhibited bacterial histidine kinase . Naphthopyrones 271 , 272 isolated from the crinoids Comanthus parvicirrus inhibited TNF-α induced NF-kB activation by inhibiting IKKβ-kinase. − Bisebromoamide ( 273 ) isolated from the marine cyanobacterium Lyngbya sp.…”

Section: Marine-derived Kinase Inhibitorsmentioning

confidence: 99%

Kinase Inhibitors of Marine Origin

et al. 2013

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“…Previous screens for inhibitors of bacterial TCST pathways have been based on detection of the autophosphorylated HK protein or the phosphorylated RR protein (71)(72)(73)(74). Of the inhibitors identified in this way, some failed to inhibit growth of microbial test strains (74), and others were found to be inadequate due to lack of specificity (75).…”

Section: Prospects For Ypd1 As An Antifungal Drug Targetmentioning

confidence: 99%

“…Of the inhibitors identified in this way, some failed to inhibit growth of microbial test strains (74), and others were found to be inadequate due to lack of specificity (75). Recent TCST-directed antibacterial efforts have focused more on the kinase sensory domain and the response regulator domain (76).…”

Section: Prospects For Ypd1 As An Antifungal Drug Targetmentioning

confidence: 99%

Histidine Phosphotransfer Proteins in Fungal Two-Component Signal Transduction Pathways

Fassler

West

2013

Eukaryot Cell

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bThe histidine phosphotransfer (HPt) protein Ypd1 is an important participant in the Saccharomyces cerevisiae multistep twocomponent signal transduction pathway and, unlike the expanded histidine kinase gene family, is encoded by a single gene in nearly all model and pathogenic fungi. Ypd1 is essential for viability in both S. cerevisiae and in Cryptococcus neoformans. These and other aspects of Ypd1 biology, combined with the availability of structural and mutational data in S. cerevisiae, suggest that the essential interactions between Ypd1 and response regulator domains would be a good target for antifungal drug development. The goal of this minireview is to summarize the wealth of data on S. cerevisiae Ypd1 and to consider the potential benefits of conducting related studies in pathogenic fungi.

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Articulosporasp. Produces Art1, an Inhibitor of Bacterial Histidine Kinase

Cited by 8 publications

References 22 publications

Variations in the Community Structure of Fungal Microbiota Associated with Apple Fruit Shaped by Fruit Bagging-Based Practice

Variations in the Community Structure of Fungal Microbiota Associated with Apple Fruit Shaped by Fruit Bagging-Based Practice

Kinase Inhibitors of Marine Origin

Histidine Phosphotransfer Proteins in Fungal Two-Component Signal Transduction Pathways

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