Antibacterial Activityof Aqueous And Ethanolic Leaf Extracts Of Vernonia Amygdalina On Selected Species Of Gram Positive And Gram Negative Bacteria

Bukar, A.; Isa, Mustafa Alhaji; Bello, Helia; Abdullahi, A. L.

doi:10.3126/ije.v2i1.9217

Cited by 11 publications

(8 citation statements)

References 14 publications

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“…A literature search performed on documented anti-typhoid activity of the plants used in formulating these preparations such as (Carica papaya [66], Vernonia amygdalina [67][68][69] Table 1) showed that all the 8 plants contained flavonoids, while 7 contained alkaloids, 6 out of the eight plants contained tannins, saponins and glycosides as secondary metabolites [70][71][72][73][74][75][76][77]. The antityphoid activity may well be due to the presence of these phytoconstituents, but further studies may need to be done to ascertain this.…”

Section: Discussionmentioning

confidence: 99%

Herbal Medicines Used in the Treatment of Typhoid in the Ga East Municipality of Ghana

Bekoe

Agyare

Sarkodie

et al. 2017

IJTDH

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In Ghana, majority of the people patronize herbal medicines for the treatment of both chronic and acute ailments as well as infectious and non-infectious diseases. As such, the use of herbs as medicines in the treatment of enteric (typhoid) fever is very widespread. Aims: This study therefore investigates anti-typhoidal herbal medicinal formulations that are for sale on the Ghanaian market with regards to the contents on the product labels and assesses the various active plant components in the light of documented evidence of their use in the treatment of typhoid. Bekoe et al.; IJTDH, 23(4): 1-13, 2017; Article no.IJTDH.31448 2 Methodology: Herbal products for the treatment of typhoid were sampled from herbal medicine shops and pharmacies and assessed for the type of formulation, plant and non-plant constituents, dosage, indications, treatment duration and contraindications. Results: Majority of the products (87%, n=16) had registration numbers whilst 13% had none. These anti-typhoid formulations were simultaneously recommended for the treatment of malaria (56%) (9 out of 16 products), jaundice (31%), various types of pains (body pains, headache, menstrual pains) (8%), stress (8%) and fatigue (8%). All the preparations had more than one plant as its active constituent. Forty-four percent (44%) contained 2 plants species as the active ingredients, 37% contained between 3 to 5 plant species, 13% contained 6 to 10 plant species and 6% contained more than 10 plant species. The most frequently occurring active plant constituents of these products were Carica papaya L. (Caricaceae), Morinda lucida (Rubiaceae), Citrus aurantifolia (Rutaceae), Vernonia amygdalina (Compositae) and Azadirachta indica (Meliaceae). Conclusion: In all, thirty-four different plant species belonging to 25 families were found to be present in these products. A literature search on the plants species showed that their traditional use in the treatment of typhoid is well documented and hence their resulting formulations may as well be very effective. Original Research Article

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Section: Discussionmentioning

confidence: 99%

Herbal Medicines Used in the Treatment of Typhoid in the Ga East Municipality of Ghana

Bekoe

Agyare

Sarkodie

et al. 2017

IJTDH

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“…Both the roots and leaves are utilized in phytomedicine for the treatment of kidney diseases, fever, stomach discomfort and hiccups, among others [20]. Bukar et al, (2013) a rmed that the sensitivity of V. amygdalina was more towards gram positive bacteria compared to the of gram-negative bacteria; However, other researchers revealed that the activity of V. amygdalina on gram-negative bacteria was comparable to its effect towards the grampositive species [18,21]. For example, methanol extract of V. amygdalina affected not only the growth of gram-positive bacteria such as B. subtilis, B. cereus, M. kristinae, B. pumilus, S. aureus and E. cloacae but exhibited potency against gram-negative bacteria which include Proteus vulgaris, Klebsiella pneumoniae, Shigella dysenteriae, Pseudomonas aeruginosa, and E. coli [22,23].…”

Section: Typhoid Fevermentioning

confidence: 99%

In-vitro Antimicrobial Activity of the Combined Effect of Kalanchoe Crenata and Vernonia Amygdalina on Salmonella Species

Effah-Yeboah

Sosa-Montes

Balali

2020

Preprint

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Abstract IntroductionThe major breakthrough in the treatment of pathogenic diseases was the unearthing of naturally occurring antipathogenic agents or antibiotics. There have been upsurges in antibiotic-resistant strains of clinically important pathogens, which made way to the emergence of new-fangled bacterial strains that are multi-resistant. The major aim of scientists is to develop new antibiotics or other therapeutic strategies at a pace greater than that at which bacteria are developing resistance. Development of resistance to first-line antimicrobial therapies made way to recommendations for combination therapies for the treatment of some infections and some of this form of chemotherapy seems to be very successful.ObjectivesThis research was carried out the determine the effect of Kalanchoe crenata extract on salmonella Tyhi load. It was carried out to also assess the potency of the extract of Vernonia amygdalina on Salmonella typhi and also to ascertain the effect of the combined extract of Kalanchoe crenata and Vernonia amygdalina on salmonella typhi.MethodIn this research, Salmonella typhi was exposed to a crude extract of Kalanchoe crenata and Vernonia amygdalina and also the combination of the two extracts. Agar wells diffusion method was employed.ResultsThe combined effect was not sensitive to the Salmonella strain. The Salmonella strain was resistant to V. amygdalina than to K. crenata. K. cranata had the strongest activity against S. typhi with its highest zone of growth inhibition of 20 mm and lowest zone of inhibition of 7 mm while V. amygdalina produced consistent zone of growth inhibition of 5–6 mm; The combined effect produced a zone inhibition diameter only at the 100 mg/ml with zone of inhibition value of 14 mm. The subsequent lower concentrations did not show any activity against the microbes. At P-value = 0.05 two-way ANOVA statistics exhibited significant difference amongst the effects produced by the different extracts, though there were no substantial differences in the effects produced by the various concentrations.ConclusionThe salmonella strain was resistant to V. amygdalina than to K. crenata. At P-value = 0.05 there was a substantial difference in the sensitivity of the bacteria to the different extracts.

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“…Penelitian terhadap aktivitas antimikroba ekstrak daun afrika (Afolabi et al, 2014) yang dilakukan menunjukkan hasil yang positif terhadap bakteri aktivitas Streptococcus mutans, Staphylococcus aureus dan Lactobacillu acidophilus. Ekstrak daun afrika memiliki aktivitas antibakteri yang mampu membunuh bakteri gram posirif dan gram negatif (Erasto, 2008;Bukar et al, 2013), antihelmintes (Nalule et al, 2013), antipiretik antinosiseptik (Adiukwu et al, 2013).…”

Section: Pendahuluanunclassified

Evaluasi Stabilitas Sediaan Krim Ekstrak Etanol Daun Afrika (Vernonia amygdalina Delile) dengan Basis Vanishing Cream (VC)

2018

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Daun afrika (Vernonia amygdalina) contains flavonoids, tannins, saponins, and terpenoids that can be used for pharmacology activity: annihilate the parasites that causing schistosomiasis, malaria leishmaniasis, antiamoeba, antitumor and antimicrobials. The purposes of this research were to screen the phytochemistry of african leaf, formulate and test the stability of vanishing cream (VC) base. The methods used were sample collection, extract preparation, formulation, and stability evaluation. The results showed that extract afrika leaves had alkaloids, flavonoids, tannins, saponins, steroids, and triterpenoids. Extract of daun afrika can be made to good VC base formula including organoleptic test, homogeneity test, pH test, spreading test, sticky test, and VC safety test by distributing questionnaires. The cream was stabil for 21 days at room temperature. Observation of physical properties good performed every week to organoleptis, pH, adhesion, and spreading power. Key words: stability, V. amygdalina, kill parasites, Vanishing Cream

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Antibacterial Activityof Aqueous And Ethanolic Leaf Extracts Of Vernonia Amygdalina On Selected Species Of Gram Positive And Gram Negative Bacteria

Cited by 11 publications

References 14 publications

Herbal Medicines Used in the Treatment of Typhoid in the Ga East Municipality of Ghana

Herbal Medicines Used in the Treatment of Typhoid in the Ga East Municipality of Ghana

In-vitro Antimicrobial Activity of the Combined Effect of Kalanchoe Crenata and Vernonia Amygdalina on Salmonella Species

Evaluasi Stabilitas Sediaan Krim Ekstrak Etanol Daun Afrika (Vernonia amygdalina Delile) dengan Basis Vanishing Cream (VC)

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