Antibacterial activity of Vicoa indica and Tridax procumbens against Multi-Drug Resistant (MDR) clinical isolates

Harish, C.C.; Safiullah, A.; Shenbagaraman, R.; Premaraj, V. Shanta; Venkatraman, Sitalakshmi; Balaji, V

doi:10.20894/stet.116.003.004.002

Cited by 2 publications

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“…However MRSA had greater impact on mortality, excess length of stay and cost more than Enterobacteriaceae infection [8]. Owing to high incidence of antibiotic-resistant microbes, natural products and herbal extracts previously reported for bioactivity have been seen as inexpensive and low or no side effects lead drugs [26]. ey are therefore can be considered appropriate and economic alternative for healing drug resistant infectious diseases [27].…”

Section: Discussionmentioning

confidence: 99%

Clinical Relevance and Antimicrobial Profiling of Methicillin-Resistant Staphylococcus aureus (MRSA) on Routine Antibiotics and Ethanol Extract of Mango Kernel (Mangifera indica L.)

Bshabshe

Joseph

El-Gied

et al. 2020

BioMed Research International

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Methicillin-resistant Staphylococcus aureus (MRSA) is known for serious health problems. Testing new inexpensive natural products such as mango kernel (Mangifera indica L., Anacardiaceae) may provide alternative and economically viable anti-MRSA drugs. In the current study, we screened clinical isolates from Aseer Central Hospital, Saudi Arabia, during 2012–2017 for MRSA and tested an ethanolic extract of mango kernel for anti-MRSA activity. Brief confirmation of MRSA was performed by the Vitek 2 system, while antibiotic sensitivity of strains was tested for their clinical relevance. The In vitro disc diffusion method was used to test the anti-MRSA activity of the ethanolic mango kernel extract. The antimicrobial activity of mango kernel was compared to that of standard drugs (oxacillin and vancomycin). Of the identified 132 S. aureus strains, 42 (31.8%) were found to be MRSA and their prevalence showed a clear increase during the last two years (2016-2017; p<0.001). MRSA strains showed 100% sensitivity to vancomycin, teicoplanin, linezolid, tetracycline, daptomycin, tigecycline, and tobramycin and 100% resistance to ampicillin and 98% to penicillin. The ethanolic extracts of mango kernel were found active against both S. aureus and the MRSA strains. Inhibitory activities (mean ± SE) were achieved at concentrations of 50 mg/mL (20.77 ± 0.61), 5 mg/mL (16.18 ± 0.34), and 0.5 mg/mL (8.39 ± 0.33) exceeding that of vancomycin (p=0.0162). MRSA strains were sensitive to mango kernel extracts when compared to vancomycin. Therefore, ethanolic extracts of mango kernel can be escalated to animal model studies as a promising leading anti-MRSA drug candidate and can be an economic alternative to high-priced synthetic antibiotics.

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Section: Discussionmentioning

confidence: 99%

Clinical Relevance and Antimicrobial Profiling of Methicillin-Resistant Staphylococcus aureus (MRSA) on Routine Antibiotics and Ethanol Extract of Mango Kernel (Mangifera indica L.)

Bshabshe

Joseph

El-Gied

et al. 2020

BioMed Research International

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“…Previously prepared aqueous and ethanolic Coccinia extract saturated 0.7 cm discs were placed onto the plates with 2 cm space and the plates were kept at 37/30 °C for 28/48 h for bacterial and fungal antimicrobial potency, respectively. MIC was inferred as the least concentration of the extracts that prevented the visible growth “zone of clearance” of the bacterial cultures ( Harish et al, 2010 ). For the sensitivity test of Candida, MHA with 2% glucose and 0.5 µg/mL methylene blue dye (MHA-GMB) was used.…”

Section: Methodsmentioning

confidence: 99%

Inhibition realization of multidrug resistant bacterial and fungal isolates using Coccinia indica extracts

Alshahrani

Ibrahim

Asiri

et al. 2022

Saudi Journal of Biological Sciences

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Antibacterial activity of Vicoa indica and Tridax procumbens against Multi-Drug Resistant (MDR) clinical isolates

Cited by 2 publications

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Clinical Relevance and Antimicrobial Profiling of Methicillin-Resistant Staphylococcus aureus (MRSA) on Routine Antibiotics and Ethanol Extract of Mango Kernel (Mangifera indica L.)

Clinical Relevance and Antimicrobial Profiling of Methicillin-Resistant Staphylococcus aureus (MRSA) on Routine Antibiotics and Ethanol Extract of Mango Kernel (Mangifera indica L.)

Inhibition realization of multidrug resistant bacterial and fungal isolates using Coccinia indica extracts

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