Antibacterial Activity of Two Zn-MOFs Containing a Tricarboxylate Linker

Abstract

Metal–organic frameworks (MOFs) can be used as reservoirs of metal ions with relevant antibacterial effects. Here, two novel Zn-based MOFs with the formulas [Zn4(μ4-O)(μ-FA)L2] (GR-MOF-8) and [Zn4(μ4-O)L2(H2O)] (GR-MOF-9) (H3L: 5-((4-carboxyphenyl)ethynyl) in isophthalic acid and FA (formate anion) were solvothermally synthetized and fully characterized. The antibacterial activity of GR-MOF-8 and 9 was investigated against Staphylococcus aureus (SA) and Escherichia Coli (EC) by the agar diffusion method. Both bacteria are among the most relevant human and animal pathogens, causing a wide variety of infections, and are often related with the development of antimicrobial resistances. While both Zn-based materials exhibited antibacterial activity against both strains, GR-MOF-8 showed the highest inhibitory action, likely due to a more progressive Zn release under the tested experimental conditions. This is particularly evidenced in the inhibition of SA, with an increasing effect of GR-MOF-8 with time, which is of great significance to ensure the disappearance of the microorganism.

ZIF-8@Hydroxyapatite Composite as a High Potential Material for Prolonged Delivery of Agrochemicals

“…Thus, the highest inhibition activity of ZIF-8@HA can be attributed to the stabilization effect of HA on its degradation profile, in agreement with the stability test (Figure S8). Thus, ZIF-8@HA acts as a metal reservoir, making it more effective in the inhibition of the pathogen growth, as previously reported in other Zn-based materials . These results demonstrate the potential of MOF@HA composites to develop multifunctional agrochemicals, improving the fertilizer and antibacterial effect of the individual components, HA and MOF, respectively.…”

“…Thus, ZIF-8@ HA acts as a metal reservoir, making it more effective in the inhibition of the pathogen growth, as previously reported in other Zn-based materials. 32 These results demonstrate the potential of MOF@HA composites to develop multifunctional agrochemicals, improving the fertilizer and antibacterial effect of the individual components, HA and MOF, respectively. 3.5.…”

“…29,30 Furthermore, ZIF-8 can efficiently inactivate both Gram-negative and Gram-positive bacteria by the production of reactive oxygen species under UV-sunlight generating oxidative stress in the bacteria, 31 as previously demonstrated with other Zn-based MOFs with excellent antibacterial activity. 32 Thus, this article reports the synthesis and complete characterization of a ZIF-8@HA composite and its evaluation as a fertilizer and antibacterial agent. This novel multitarget composite material can release in a controlled manner several micronutrients (Ca, P, and Zn), leading to a higher yield in wheat growth and improving the antibacterial activity against Pseudomonas syringae (Ps).…”

Green synthesis of biocompatible Fe3O4 magnetic nanoparticles using Citrus Sinensis peels extract for their biological activities and magnetic-hyperthermia applications

“…The World Health Organization (WHO) finds it particularly concerning that multi- and pan-resistant bacteria are rapidly spreading worldwide and causing diseases that are not treatable with the current antimicrobial medications such antibiotics, antivirals, antifungals, etc. 2 . Studies using diverse plant components, including leaf, flowers, roots, stems, seeds, and peels extracts, to biosynthesize NPs have drawn attention to use plant extracts as platforms for MNP synthesis.…”

Antibacterial Cu or Zn-MOFs Based on the 1,3,5-Tris-(styryl)benzene Tricarboxylate

“…In this regard, transition metal based materials appear to be a promising alternative because they exhibit low toxicity and a relatively low cost. They can present compelling properties as pure metal nanoparticles [ 3 ], oxide particles [ 4 ], or ions [ 5 ]. Zinc (II) and copper (II) ions are particularly interesting for antibacterial applications since they are involved in numerous biological pathways.…”