Antibacterial Cu or Zn-MOFs Based on the 1,3,5-Tris-(styryl)benzene Tricarboxylate

Abstract

Metal–organic frameworks (MOFs) are highly versatile materials. Here, two novel MOFs, branded as IEF-23 and IEF-24 and based on an antibacterial tricarboxylate linker and zinc or copper cations, and holding antibacterial properties, are presented. The materials were synthesized by the solvothermal route and fully characterized. The antibacterial activity of IEF-23 and IEF-24 was investigated against Staphylococcus epidermidis and Escherichia coli via the agar diffusion method. These bacteria are some of the most broadly propagated pathogens and are more prone to the development of antibacterial resistance. As such, they represent an archetype to evaluate the efficiency of novel antibacterial treatments. MOFs were active against both strains, exhibiting higher activity against Staphylococcus epidermidis. Thus, the potential of the developed MOFs as antibacterial agents was proved.

Studying Fluorescence Sensing of Acetone and Tryptophan and Antibacterial Properties Based on Zinc-Based Triple Interpenetrating Metal–Organic Skeletons

“…The OD values of the experimental group were significantly lower than those of the control group, indicating that the two materials significantly inhibited the growth of both bacteria at each test point. The results reflect the broad-spectrum antibacterial properties of the two materials [42,43]. Zn(NO 3 ) 2 •6H 2 O (10.1 mg, 0.034 mmol), 1,4-bpeb (4.8 mg, 0.017 mmol), IPA (2.8 mg, 0.017 mmol), 3 mL DMSO, and 1 mL MeOH were placed in a 10 mL glass bottle with 1 mL 0.1 mM aqueous KOH solution.…”

“…The OD values of the experimental group were significantly lower than those of the control group, indicating that the two materials significantly inhibited the growth of both bacteria at each test point. The results reflect the broad-spectrum antibacterial properties of the two materials [42,43]. In addition, the minimum inhibitory concentration and inhibitory dynamic curve were investigated; the minimum inhibitory concentrations of MOF-1 against Escherichia coli and Staphylococcus aureus were 19.52 µg/mL and 39.06 µg/mL, respectively.…”

A new MOF@bioactive glass composite reinforced with silver nanoparticles – a new approach to designing antibacterial biomaterials

“…There is also an increasing number of Cu-MOFs being tested and used for their antimicrobial activity. 9–11 A well-known representative is [Cu 3 (BTC) 2 ] n (H 3 BTC = 1,3,5-benzenetricarboxylic acid), commonly known as Cu-HKUST-1 or MOF-199, which has remarkable antibacterial activity against S. aureus and E. coli. 11–15 The progressive degradation of Cu-MOFs and the leaching of Cu 2+ ions as well as the ligand, e.g.…”