Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pylori

Park, Byeoung-Soo; Lee, Hyun-Kyung; Lee, Sung‐Eun; Piao, Xiang‐Lan; Takeoka, Gary R.; Wong, Rosalind Y.; Ahn, Young‐Joon; Kim, Jeong‐Han

doi:10.1016/j.jep.2005.11.005

Cited by 117 publications

(68 citation statements)

References 38 publications

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“…Penetration of antibacterial agents to this site from either the lumen of the stomach or the gastric blood supply is limited. The pH of gastric secretions and sites within the mucosa may also affect drug activity (Park et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

“…H. pylori infection is recognized as an important causative agent of gastroduodenal diseases, including chronic gastritis, peptic ulceration, gastric adenocarcinoma, and gastric lymphoma (Park et al, 2006;Ding et al, 2007;Wang et al, 2008;Pastene et al, 2009). Studies have shown an association between long-term infection with H. pylori and the development of gastric adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

“…Treatment of H. pylori infection consists of 1-2 weeks of 1 or 2 effective antibiotics, including amoxicillin, tetracycline, metronidazole, or clarithromycin, plus ranitidine bismuth citrate, bismuth subsalicylate, or a proton pump inhibitor (Howden & Hunt, 1998;Duynhoven & Jonge, 2001;Park et al, 2006). However, this triple therapy is not always successful in eradicating the infection, and the acquisition of antibiotic resistance by H. pylori could reduce treatment efficacy and present a serious problem (Bonacorsi et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes

Kitagawa¹,

Bonacorsi²,

Fonseca³

et al. 2012

Rev. bras. farmacogn.

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Abstract:Helicobacter pylori is a bacterium recognized as the major cause of chronic gastritis and peptic ulcers. Infection by H. pylori induces inflammatory responses and pathological changes in the gastric microenvironment. The host immune cells (especially neutrophils) release inflammatory mediators and large amounts of reactive oxygen species (ROS), which are associated with an increased risk of developing gastric cancer. In this study, we evaluated the anti-H. pylori and antioxidant activities of a 1,4-naphthoquinone-5-methoxy-3,4-dehydroxanthomegnin. The antimicrobial activity was assessed using a spectrophotometric microdilution technique, and antioxidant activity was assessed by noting the effect of 5-methoxy-3,4-dehydroxanthomegnin on the neutrophil oxidative burst using luminol-and lucigenin-amplified chemiluminescence. The results showed that 5-methoxy-3,4-dehydroxanthomegnin is a potent anti-H. pylori compound (MIC 64 µg/mL and MBC 128 µg/mL) and a strong antioxidant. 5-Methoxy-3,4-dehydroxanthomegnin decreased luminol-and lucigenin-amplified chemiluminescence, with ED50 values of 1.58±0.09 µg/mL and 5.4±0.15 µg/mL, respectively, reflecting an inhibitory effect on the oxidative burst. These results indicate that 5-methoxy-3,4-dehydroxanthomegnin is a promising compound for the prevention and treatment of diseases caused by H. pylori infection, such as gastritis, peptic ulceration, and gastric cancer, because reactive oxygen intermediates are involved in the pathogenesis of gastric mucosal injury induced by H. pylori infections.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes

Kitagawa¹,

Bonacorsi²,

Fonseca³

et al. 2012

Rev. bras. farmacogn.

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“…It is commercially important as a major source of plumbagin ( Figure 1). Plumbagin is a naphthoquinone compound that possesses a broad range of pharmacological activities such as anticancer (Wang et al, 2008), antimicrobial (Kaewbumrung & Panichayupakaranant, 2012;Park et al, 2006), anti-protozoal (Fournet et al, 1992), anthelmintic (Atjanasuppat et al, 2009) and antifertility (Kini et al, 1997) activities. Nowadays, P. indica roots are being used increasingly as ingredients in marketed phytomedicines.…”

Section: Introductionmentioning

confidence: 99%

Increased production of plumbagin inPlumbago indicaroot cultures by gamma ray irradiation

Jaisi¹,

Sakunphueak

Panichayupakaranant

2013

Pharmaceutical Biology

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Context: Plumbagin is a major active constituent of Plumbago indica L. (Plumbaginaceae). It possesses various pharmacological activities that have been shown to assist in the treatment of various diseases. Objectives: This work is focused on increasing the production of plumbagin in P. indica root cultures using low doses of gamma ray irradiation as an elicitor. Materials and methods: The effect of low doses of gamma ray irradiation (0, 5, 10, 15, 20, 25 Gy) and ages of the root cultures (0, 5, 10, 15, 20 days) for elicitation of plumbagin production was determined. The stability of the elicited root cultures to produce plumbagin was also determined during three cycles of subculture. Results and discussion: Treatment of the root cultures with a low dose of gamma ray at 20 Gy gave the highest level of plumbagin production (1.04 mg/g DW) when compared to all other treated groups. The appropriate age of the root cultures for maximum production of plumbagin was found to be 10 days. However, treatment of 5-day-old root cultures resulted in a significant increase of dried root biomass that also had a high plumbagin production. Based on the total biomass per culture flask, the amounts of plumbagin produced by the 5-and 10-day-old treated roots were 0.59 and 0.37 mg/250 mL flask, respectively, which were 4.2-and 2.6-fold higher than the level in the control. Subculturing the root cultures until the third generation still showed an increase in plumbagin production without any effects on their growth.

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“…Taheebo, a naturally occurring constituent of the inner bark of the Tabebuia avellandae tree found in the Brazilian Amazon, has been used for over 1,500 years in South America to treat a variety of health conditions (9)(10)(11). In the USA, Taheebo is available as a nutritional supplement under the name Pau d'Arco tea.…”

Section: Introductionmentioning

confidence: 99%

Growth inhibition of estrogen receptor positive human breast cancer cells by Taheebo from the inner bark of Tabebuia avellandae tree

Mukherjee

Telang²,

Wong³

2009

Int J Mol Med

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Abstract. Selective estrogen receptor (ER) modulators are used as a therapy for ER + clinical breast cancer, but they exhibit adverse effects. Herbal medicines may provide an alternative or complementary approach. Taheebo, extracted from the inner bark of the Tabebuia avellandae tree found in the Brazilian Amazon, exhibits selective anti-proliferative effects in carcinoma cell lines. The present study identifies the mechanistic leads for the inhibitory effects of Taheebo. Human breast carcinoma derived ER + MCF-7 cells were used as the model. Aqueous extract of Taheebo was the test compound. Cell cycle analysis, clonogenic assay, and global gene expression profiles were the quantitative parameters. Taheebo treatment resulted in a dose/time-dependent growth inhibition (S phase arrest, reduced clonogenecity) and initiation of apoptosis (chromatin condensation). A 6-h treatment with 1.5 mg/ml Taheebo modulated the gene expression of G2 specific cyclin B1 (-2.0-fold); S phase specific PCNA (-2.0-fold) and OKL38 (+11.0-fold); apoptosis specific GADD-45 family (+1.9-5.4-fold), Caspases (+1.6-1.7-fold), BCL-2 family (-1.5-2.5-fold), estrogen responsive ESR1 (-1.5-fold), and xeno-biotic metabolism specific CYP 1A1 (+19.8 fold) and CYP 1B1 (+7.9-fold). The anti-proliferative effects of Taheebo correlate with down-regulated cell cycle regulatory and estrogen responsive genes, and up-regulated apoptosis specific and xeno-biotic metabolism specific genes. These data validate a rapid mechanistic approach to prioritize efficacious herbal medicines, thereby complementing the existing endocrine therapy for breast cancer.

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Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pylori

Cited by 117 publications

References 38 publications

Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes

Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes

Increased production of plumbagin inPlumbago indicaroot cultures by gamma ray irradiation

Growth inhibition of estrogen receptor positive human breast cancer cells by Taheebo from the inner bark of Tabebuia avellandae tree

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