Antibacterial activity of Syzigium cumini leaf extracts against multidrug resistant pathogenic bacteria

doi:10.7324/japs.2017.70327

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…Apart from this, chloramphenicol against S. aureus MTCC 96 also showed a MIC value of 12.5 μg/mL . Similarly, the MIC value of gentamicin against this specific strain of B.…”

Section: Resultsmentioning

confidence: 79%

“…107 According to earlier literature, observed MIC of ampicillin against the specific strains of S. aureus (MTCC 96) and E. coli (MTCC 443) was 0.19 and 0.04 mg/mL and are higher than our reported result (12.5 μg/mL against S. aureus and 25 μg/mL against E. coli). 108 Apart from this, chloramphenicol against S. aureus MTCC 96 also showed a MIC value of 12.5 μg/mL. 108 Similarly, the MIC value of gentamicin against this specific strain of B. cereus (MTCC 430) was reported to be 0.31 mg/ mL, which is quite higher than the obtained MIC value of hydrogel (μg/mL).…”

Section: Resultsmentioning

confidence: 90%

“…108 Apart from this, chloramphenicol against S. aureus MTCC 96 also showed a MIC value of 12.5 μg/mL. 108 Similarly, the MIC value of gentamicin against this specific strain of B. cereus (MTCC 430) was reported to be 0.31 mg/ mL, which is quite higher than the obtained MIC value of hydrogel (μg/mL). 109 The antimicrobial activity of silver nanoparticles is dependent on their shape and size.…”

Section: Resultsmentioning

confidence: 90%

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Hierarchical Assembly of Nanodimensional Silver–Silver Oxide Physical Gels Controlling Nosocomial Infections

et al. 2020

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Microbial infections originating from medical care facilities are raising serious concerns across the globe. Therefore, nanotechnology-derived nanostructures have been investigated and explored due to their promising characteristics. In view of this, silver-based antimicrobial hydrogels as an alternative to antibiotic-based creams could play a crucial role in combating such infections. Toward this goal, we report a simple method for the synthesis and assembly of silver nanoparticles in a biopolymer physical gel derived from Abroma augusta plant in imparting antimicrobial properties against nosocomial pathogens. Synthesized silver nanoparticles (diameter, 30 ± 10 nm) were uniformly distributed inside the hydrogel. Such synthesized hydrogel assembly of silver nanoparticles dispersed in the biopolymer matrix exhibited hemocompatibility and antimicrobial and antibiofilm characteristics against nosocomial pathogens. The developed hydrogel as a surface coating offers reduced hardness and modulus value, thereby minimizing the brittleness tendency of the gel in the dried state. Hence, we believe that the hierarchical assembly of our hydrogel owing to its functional activity, host toxicity, and stability could possibly be used as an antimicrobial ointment for bacterial infection control.

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“…Apart from this, chloramphenicol against S. aureus MTCC 96 also showed a MIC value of 12.5 μg/mL . Similarly, the MIC value of gentamicin against this specific strain of B.…”

Section: Resultsmentioning

confidence: 79%

Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 90%

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Hierarchical Assembly of Nanodimensional Silver–Silver Oxide Physical Gels Controlling Nosocomial Infections

et al. 2020

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Review on the Antibacterial Mechanism of Plant-Derived Compounds against Multidrug-Resistant Bacteria (MDR)

Jubair

Rajagopal

Chinnappan

et al. 2021

Evidence-Based Complementary and Alternative Medicine

107

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Microbial resistance has progressed rapidly and is becoming the leading cause of death globally. The spread of antibiotic-resistant microorganisms has been a significant threat to the successful therapy against microbial infections. Scientists have become more concerned about the possibility of a return to the pre-antibiotic era. Thus, searching for alternatives to fight microorganisms has become a necessity. Some bacteria are naturally resistant to antibiotics, while others acquire resistance mainly by the misuse of antibiotics and the emergence of new resistant variants through mutation. Since ancient times, plants represent the leading source of drugs and alternative medicine for fighting against diseases. Plants are rich sources of valuable secondary metabolites, such as alkaloids, quinones, tannins, terpenoids, flavonoids, and polyphenols. Many studies focus on plant secondary metabolites as a potential source for antibiotic discovery. They have the required structural properties and can act by different mechanisms. This review analyses the antibiotic resistance strategies produced by multidrug-resistant bacteria and explores the phytochemicals from different classes with documented antimicrobial action against resistant bacteria, either alone or in combination with traditional antibiotics.

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GC-MS Analysis and Evaluation of Combination effect of Syzygium cumini L. Skeels Ethanolic Seed Extract and Vancomycin against Clinical Methicillin-Resistant Staphylococcus aureus

Misrahanum,

Novita Rezeki,

Cazia

et al. 2024

RJPT

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Syzygium cumini (L.) has been traditionally used as an antimicrobial agent and is potential to be developed. The ethanol extract of S. cumini seed was obtained through maceration and assessed for its antibacterial activity using a dilution method, with extract concentrations of 1.625; 3.125; 6.25; 12.5, and 25mg/ml. The minimum inhibitory concentration (MIC) and fractional inhibitory concentration index (FICI) of the extract-antibiotic combination against Methicillin-Resistant Staphylococcus aureus were determined. Phytochemical screening was performed using Gas Chromatography-Mass Spectrometry (GC-MS) and the result revealed the presence of 22 compounds in S. cumini ethanolic seed extract, including fatty acids (69.63%), sesquiterpenes (11.29%), monoterpenes (2.94%), steroids (6.06%), and others (8.59%). The MIC of the single extract and vancomycin against the tested bacteria was 0.78mg/ml and 2µg/ml, respectively. The lowest concentration (MIC) of the extract-vancomycin combination inhibiting the growth of MRSA was 0.39mg/ml. The FICI value was 1.5, suggesting indifferent interaction between the extract and antibiotic.

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Antibacterial activity of Syzigium cumini leaf extracts against multidrug resistant pathogenic bacteria

Cited by 3 publications

References 5 publications

Hierarchical Assembly of Nanodimensional Silver–Silver Oxide Physical Gels Controlling Nosocomial Infections

Hierarchical Assembly of Nanodimensional Silver–Silver Oxide Physical Gels Controlling Nosocomial Infections

Review on the Antibacterial Mechanism of Plant-Derived Compounds against Multidrug-Resistant Bacteria (MDR)

GC-MS Analysis and Evaluation of Combination effect of Syzygium cumini L. Skeels Ethanolic Seed Extract and Vancomycin against Clinical Methicillin-Resistant Staphylococcus aureus

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