Antibacterial Activity of Oriental Medicinal Herb Extracts against Skin Pathogens

Abstract

The antibacterial activity of methanol extracts from 70 kinds of oriental medicinal herbs on four strains of Staphylococcus aureus and S. epidermidis was investigated. The results showed that C. japonica, C. sappan, R. javanica, R. tanguticum, and S. miltiorrhiza had an antibacterial activity on all the strains used. Among these, C. japonica and R. javanica, which showed excellent antibacterial activity, were extracted with water, ethanol, methanol, and ethyl acetate for further study of antibacterial activities. The results showed that the boiled water extract of C. japonica had the best antibacterial activity. Assuming that the antibacterial activity of C. japonica originated from berberine, which has been reported many times, the berberine content of the boiled water extract of C. japonica was analyzed and the result was 13.88%. To compare the antibacterial activity of berberine with that of other antibiotics, berberine chloride and three other kinds of antibiotics were investigated, which showed that berberine chloride had an antibacterial activity on KCCM 35494 S. epidermidis only when the concentration was higher than 600 mg/l, and it did not show antibacterial activity in the other strains. Based on these results, it was concluded that the antibacterial activity of the boiled water extract of C. japonica on the strains used in this study originated from high concentration of berberine or substances other than berberine. Therefore, identification of the substance will be necessary.

Effect of Reducing Inflammation of Coptis chinensis Extract -Ceramide Complex through ECS Control in Atopic Dermatitis

“…Coptis chinensis extract-ceramide complex suppresses inflammation and restores skin damage with its cleansing heat and detoxifying effect. [10][11][12] .…”

“…Coptis chinensis (黃連) has medicinal effects of 'clear heat and dry dampness (淸熱燥濕)' and 'purge fire and detoxify (瀉火解毒)', and also has antiviral and antibacterial effects 10,11) . According to previous study 12) , Coptis chinensis is also effective Through this, we report the possibility that Coptis chinensis extract-ceramide complex can alleviate the inflammatory response of atopic dermatitis.…”