Electrospun poly(vinyl alcohol) nanofibrous membranes containing <i>Coptidis Rhizoma</i> extracts for potential biomedical applications

Jeong, Jin Hwan; Lee, Seungsin

doi:10.1177/0040517518813679

Cited by 14 publications

(6 citation statements)

References 27 publications

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“…Recently, electrospun poly(vinyl alcohol) nanofibrous membranes containing Coptidis Rhizoma extracts have been fabricated and shown good antibacterial activity. 26 , 27 But the effect of these membranes on wound healing and HS formation has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Palmatine-loaded electrospun poly(ε-caprolactone)/gelatin nanofibrous scaffolds accelerate wound healing and inhibit hypertrophic scar formation in a rabbit ear model

Jiang

Zhao

et al. 2020

J Biomater Appl

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Hypertrophic scar (HS) has been considered as a great concern for patients and a challenging problem for clinicians as it can cause functional debility, cosmetic disfigurement and psychological trauma. Although many methods have been developed to prevent and treat HS, the scarless healing is still a worldwide medical problem. In this study, palmatine-loaded poly( ε-caprolactone)/gelatin nanofibrous scaffolds (PCL/GE/PALs) were fabricated by electrospinning, and their effects on wound healing and HS formation were investigated. These nanofiber mats exhibit good antibacterial and antioxidant activities. In vitro studies indicate PCL/GE/PAL scaffolds can facilitate the adhesion, spreading and proliferation of L929 fibroblasts. In vivo tests demonstrate the full-thickness wounds treated with PCL/GE/PAL scaffolds heal about 3.5 days earlier than those in the control group. Scar elevation index measurements and histological analyses reveal PCL/GE/PAL scaffolds significantly inhibit HS formation, with the decrease in the thickness of dermis and epidermis, the number of fibroblasts, as well as the density of collagen and microvascular. Accelerating wound healing and inhibiting HS formation of these scaffolds are contributed to the sustained release of palmatine. The present work validates the potential use of palmatine-loaded electrospun nanofibrous scaffold PCL/GE/PALs as a functional wound dressing for healing wounds and preventing HS formation.

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Section: Introductionmentioning

confidence: 99%

Palmatine-loaded electrospun poly(ε-caprolactone)/gelatin nanofibrous scaffolds accelerate wound healing and inhibit hypertrophic scar formation in a rabbit ear model

Jiang

Zhao

et al. 2020

J Biomater Appl

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“…The ethyl acetate Rhodomyrtus tomentosa extract, rich in myricetin and rhodomyrtosone, was involved in the fabrication of electrospun nanofibers; the antimicrobial experiments against the common human pathogens ( E. coli , P. aeruginosa , B. subtilis, and E. faecalis ) displayed a clear inhibition zone (7–12 mm) by loading the extract in the concentration range of 1.5–2.5% ( w/w ) [ 113 ]. Finally, nanofibers containing Coptidis rhizoma extracts (10, 20, and 30% w/w ) were fabricated using PVA as a carrier [ 114 ]. The release experiments performed at physiological pH of 5.5, set by acetate buffer solution, displayed an initial fast release, followed by a gradual release for 48 h. In addition, high antimicrobial activity was recorded against S. aureus (max inhibition zone 17.0 mm) and S. epidermidis (max inhibition zone 6.2 mm).…”

Section: Nanofibers As Carriers Of Antimicrobial Natural Productsmentioning

confidence: 99%

Nanotechnologies: An Innovative Tool to Release Natural Extracts with Antimicrobial Properties

et al. 2021

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Site-Specific release of active molecules with antimicrobial activity spurred the interest in the development of innovative polymeric nanocarriers. In the preparation of polymeric devices, nanotechnologies usually overcome the inconvenience frequently related to other synthetic strategies. High performing nanocarriers were synthesized using a wide range of starting polymer structures, with tailored features and great chemical versatility. Over the last decade, many antimicrobial substances originating from plants, herbs, and agro-food waste by-products were deeply investigated, significantly catching the interest of the scientific community. In this review, the most innovative strategies to synthesize nanodevices able to release antimicrobial natural extracts were discussed. In this regard, the properties and structure of the starting polymers, either synthetic or natural, as well as the antimicrobial activity of the biomolecules were deeply investigated, outlining the right combination able to inhibit pathogens in specific biological compartments.

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“…Although various antimicrobial agents have been utilized to control microbial infections [26][27][28][29][30], synthetic biocides can cause skin irritation or allergy. Thus, natural plant-derived antimicrobial agents, which are environmentally friendly and non-toxic, have attracted much attention as a result of their potential for use in home textiles where textiles are in direct contact with human skin.…”

Section: Antibacterial Properties Of Core/sheath-structured Nanofibermentioning

confidence: 99%

Core/Sheath-Structured Composite Nanofibers Containing Cinnamon Oil: Their Antibacterial and Antifungal Properties and Acaricidal Effect against House Dust Mites

et al. 2020

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This study aimed to fabricate core/sheath-structured composite nanofibers containing cinnamon oil by emulsion electrospinning and to investigate their acaricidal effect on house dust mites as well as their antibacterial and antifungal properties in relation to cinnamon oil concentration in the nanofibers. An oil-in-water emulsion, which comprised cinnamon oil and poly(vinyl alcohol) solution as oil and water phases, respectively, was used to prepare core/sheath-structured nanofibers. The morphology and the inner structure of the electrospun nanofibers were observed by scanning electron microscopy and confocal laser scanning microscopy. Core/sheath-structured nanofibers containing cinnamon oil were successfully prepared by emulsion electrospinning. The composite nanofibers prepared from an emulsion containing 20 wt% of cinnamon oil exhibited a strong acaricidal effect against house dust mites (Dermatophagoides farinae). The composite nanofibers fabricated from an emulsion containing 4.29 wt% of cinnamon oil showed excellent antimicrobial effects against Staphylococcus aureus and a series of fungi that can trigger respiratory- and skin-related diseases. The release profile of cinnamon oil from the core/sheath-structured nanofibers showed a continuous release of functional ingredients over 28 days. Our findings demonstrate that the use of such fibrous structures could be a promising approach for delivering naturally derived bioactive agents in a controlled way.

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Electrospun poly(vinyl alcohol) nanofibrous membranes containing Coptidis Rhizoma extracts for potential biomedical applications

Cited by 14 publications

References 27 publications

Palmatine-loaded electrospun poly(ε-caprolactone)/gelatin nanofibrous scaffolds accelerate wound healing and inhibit hypertrophic scar formation in a rabbit ear model

Palmatine-loaded electrospun poly(ε-caprolactone)/gelatin nanofibrous scaffolds accelerate wound healing and inhibit hypertrophic scar formation in a rabbit ear model

Nanotechnologies: An Innovative Tool to Release Natural Extracts with Antimicrobial Properties

Core/Sheath-Structured Composite Nanofibers Containing Cinnamon Oil: Their Antibacterial and Antifungal Properties and Acaricidal Effect against House Dust Mites

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