Antibacterial Activity of <i>Lactobacillus acidophilus</i> Strains Isolated from Honey Marketed in Malaysia against Selected Multiple Antibiotic Resistant (MAR) Gram‐Positive Bacteria

Aween, Mohamed Mustafa; Hassan, Zaiton; Muhialdin, Belal J.; Eljamel, Yossra A.; Al-Mabrok, Asma Saleh W.; Lani, Mohd Nizam

doi:10.1111/j.1750-3841.2012.02776.x

Cited by 61 publications

(34 citation statements)

References 37 publications

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“…126 Experimental studies have shown that lactobacilli, which can adhere to enterocytes, are effective in preventing the enteropathogen-mediated infection by competing for nutrients 127 and binding sites (eg,inducing intestinal mucin gene expression), [128][129][130][131][132] by secreting antimicrobial substances 133 such as organic acids, 134-142 bacteriocins [143][144][145] and hydrogen peroxide [146][147][148][149][150][151][152] and eventually by counteracting the spread within the colonised body, [153][154][155] reducing gut pH 133 141 156 and producing biosurfactants. [157][158][159] As far as bacterial activity is concerned, L. plantarum GK81, L. acidophilus GK20 and L. plantarum JSA22 inhibit Salmonella spp infection in intestinal epithelial …”

Section: Antibacterial and Antiviral Activitymentioning

confidence: 99%

Mechanisms and therapeutic effectiveness of lactobacilli

et al. 2015

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The gut microbiome is not a silent ecosystem but exerts several physiological and immunological functions. For many decades, lactobacilli have been used as an effective therapy for treatment of several pathological conditions displaying an overall positive safety profile. This review summarises the mechanisms and clinical evidence supporting therapeutic efficacy of lactobacilli. We searched Pubmed/Medline using the keyword ‘Lactobacillus’. Selected papers from 1950 to 2015 were chosen on the basis of their content. Relevant clinical and experimental articles using lactobacilli as therapeutic agents have been included. Applications of lactobacilli include kidney support for renal insufficiency, pancreas health, management of metabolic imbalance, and cancer treatment and prevention. In vitro and in vivo investigations have shown that prolonged lactobacilli administration induces qualitative and quantitative modifications in the human gastrointestinal microbial ecosystem with encouraging perspectives in counteracting pathology-associated physiological and immunological changes. Few studies have highlighted the risk of translocation with subsequent sepsis and bacteraemia following probiotic administration but there is still a lack of investigations on the dose effect of these compounds. Great care is thus required in the choice of the proper Lactobacillus species, their genetic stability and the translocation risk, mainly related to inflammatory disease-induced gut mucosa enhanced permeability. Finally, we need to determine the adequate amount of bacteria to be delivered in order to achieve the best clinical efficacy decreasing the risk of side effects.

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Section: Antibacterial and Antiviral Activitymentioning

confidence: 99%

Mechanisms and therapeutic effectiveness of lactobacilli

et al. 2015

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“…Overall, broadly similar bacterial families have been isolated from different honey bee species. Although previously, the bacteria from the gut of bees has been found to exert antimicrobial activity against P. larvae (Evans and Armstrong, 2006) and antibiotic resistant bacteria (Aween et al, 2012), the potential probiotic activity, if any, of these 17 isolates from A. cerana indica in Thailand remains to be established. Figure S1.…”

Section: Discussionmentioning

confidence: 99%

Pathogen detection and gut bacteria identification in Apis cerana indica in Thailand

Nonthapa¹,

Chanchao²

2015

Afr. J. Biotechnol.

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Pathogen infection of honeybees can lead to economic losses in apiculture. The earlier the pathogen contamination can be found the better it will likely be for the treatment of the infected colony and prevention of the spread of the pathogen within and between colonies. A total of 50 colonies of Apis cerana were sampled in Samut-Songkhram (five colonies) and Chumphon (45 colonies) provinces in the central and the south of Thailand, respectively. Diagnostic multiplex polymerase chain reaction (PCR) revealed that 20, 6, 4, 20 and 0% of the samples were infected by Paenibacillus larvae, Nosema ceranae, Nosema apis, Ascosphaera apis and Sacbrood virus (Morator aetatulus), respectively. Positive amplified PCR products of target genes were sequenced. A phylogenetic tree was constructed by the neighbor-joining (NJ) distance based, using the Phylogenetic Analysis Using Parsimony (PAUP 4.0b10) program. The phylogenetic relationship of each pathogen, based on the partial sequence of the 16S rRNA of P. larvae, N. ceranae and N. apis, and of the 5.8S rRNA of A. apis, revealed a significant difference from the non-Thai isolates of these pathogens, but no significant geographical isolation between the different Thai apiaries, although it separated some into closely related clusters. In order to reduce the use of antibiotics in an apiary, bacteria in the gut of healthy bees were focused. Interestingly, Bifidobacterium species, Lactobacillus species, Bacillus species, Lactobacillus spp. and other lactic acid bacteria, were isolated from larvae and adult workers, but gave conflicting preliminary identities based on their biochemistry-morphology versus sequence analysis of a partial fragment (1.4 kb) of their 16S rRNA.

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“…Its antibacterial properties have been extensively documented. 4 Nevertheless, studies on antifungal effects of local honeys are still limited.…”

Section: Introductionmentioning

confidence: 99%

Antifungal Effect of Three Local Malaysian Honeys on Selected Pathogenic Fungi of Otomycosis: An in vitro Evaluation

Hamid¹,

Mohamad²,

Harun³

et al. 2018

JYP

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Antibacterial Activity of Lactobacillus acidophilus Strains Isolated from Honey Marketed in Malaysia against Selected Multiple Antibiotic Resistant (MAR) Gram‐Positive Bacteria

Cited by 61 publications

References 37 publications

Mechanisms and therapeutic effectiveness of lactobacilli

Mechanisms and therapeutic effectiveness of lactobacilli

Pathogen detection and gut bacteria identification in Apis cerana indica in Thailand

Antifungal Effect of Three Local Malaysian Honeys on Selected Pathogenic Fungi of Otomycosis: An in vitro Evaluation

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