Antibacterial Activity of Halophilic Bacteria Against Drug-Resistant Microbes Associated with Diabetic Foot Infections

Henciya, Santhaseelan; Vengateshwaran, Thasu Dinakaran; Gokul, M; Dahms‬, Hans-Uwe; James, Rathinam Arthur

doi:10.1007/s00284-020-02190-1

Cited by 17 publications

(14 citation statements)

References 37 publications

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“…Halophilic P. aeruginosa shows antibacterial activity against MRSA with MIC (Minimum Inhibition Concentration) at 250 µg/mL [62,63]. The ethyl acetate extract of halophilic P. aeruginosa isolated from coastal saltpan sediments exhibits broad antibacterial activity against Norfloxacin and Ciprofloxacin-resistant Klebsiella quasivariicola, vancomycin-intermediate E. coli, and methicillin, as well as Norfloxacin-resistant S. argenteus isolates from diabetic foot infections, with inhibition zones with diameters of 24, 21, and 22 mm [64]. The halophilic actinomycete, Nocardiopsis sp.…”

Section: Biopotency Of Halophiles As Antibacterials For Clinical Drug...mentioning

confidence: 99%

Recent Antimicrobial Responses of Halophilic Microbes in Clinical Pathogens

et al. 2022

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Microbial pathogens that cause severe infections and are resistant to drugs are simultaneously becoming more active. This urgently calls for novel effective antibiotics. Organisms from extreme environments are known to synthesize novel bioprospecting molecules for biomedical applications due to their peculiar characteristics of growth and physiological conditions. Antimicrobial developments from hypersaline environments, such as lagoons, estuaries, and salterns, accommodate several halophilic microbes. Salinity is a distinctive environmental factor that continuously promotes the metabolic adaptation and flexibility of halophilic microbes for their survival at minimum nutritional requirements. A genetic adaptation to extreme solar radiation, ionic strength, and desiccation makes them promising candidates for drug discovery. More microbiota identified via sequencing and ‘omics’ approaches signify the hypersaline environments where compounds are produced. Microbial genera such as Bacillus, Actinobacteria, Halorubrum and Aspergillus are producing a substantial number of antimicrobial compounds. Several strategies were applied for producing novel antimicrobials from halophiles including a consortia approach. Promising results indicate that halophilic microbes can be utilised as prolific sources of bioactive metabolites with pharmaceutical potentialto expand natural product research towards diverse phylogenetic microbial groups which inhabit salterns. The present study reviews interesting antimicrobial compounds retrieved from microbial sources of various saltern environments, with a discussion of their potency in providing novel drugs against clinically drug-resistant microbes.

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Section: Biopotency Of Halophiles As Antibacterials For Clinical Drug...mentioning

confidence: 99%

Recent Antimicrobial Responses of Halophilic Microbes in Clinical Pathogens

et al. 2022

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“…DMSO was employed as a negative control. Ciprofloxacin and Griesofulvin were used as positive controls [13][14][15][16][17][18].…”

Section: Determination Of Antimicrobial Activitymentioning

confidence: 99%

In-vitro Antibacterial and Antifungal Activity of Curcuma Amada Roxb. against Human Pathogens

Kashyap

Deepak²,

Bhardwaj³

et al. 2022

Trends Sci

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This investigation was conducted to evaluate the antimicrobial effectiveness of the agar disc diffusion method and to determine the inhibition zone of Curcuma amada (CA) rhizome extracts (petroleum ether, dichloromethane, and chloroform) against 12 bacterial species and 4 fungal species. The inhibition zones of the extracts were compared to those of Ciprofloxacin and Griseofulvin for antibacterial and antifungal activities, respectively. The findings revealed that the organisms under examination showed significant inhibition of bacterial as well as fungal development during the experiment and that the typical form of C. amada rhizome can be used to treat bacterial and fungal illnesses. So, this plant could be used to find natural compounds that are bioactive and could be used to make new medicines. HIGHLIGHTS Extracts of amada rhizome were found to protect humans from pathogens aureus bacteria had the highest inhibition zone (17 mm) in dichloromethane extract, whereas B. subtilis and B. pumilus bacteria had the lowest inhibition zone (7.5 mm) in C. amada rhizome petroleum ether extract notatum in petrolieum ether extract and A. niger in chloroform extract had the highest inhibition zones (13.5 mm), whereas P. funiculosum in chloroform extract of C. amada rhizome had the lowest inhibition zone (10 mm) GRAPHICAL ABSTRACT

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“…The whole-genome sequencing data showed that there was an extended-spectrum β-lactamases enzyme gene in K. quasivariicola genome, which suggested its potential for causing the serious human infections (15). Later, K. quasivariicola strains were successively isolated from the wound infections of a diabetic foot infected patient and the urine samples of community-acquired infections (16, 17). Our results indicated that Klebsiella quasivariicola was a potential pathogen in pulmonary infection.…”

Section: Introductionmentioning

confidence: 99%

Dopamine promotesKlebsiella quasivariicolaproliferation and inflammatory response in the presence of macrophages

Yan

Cheng

et al. 2023

Preprint

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Klebsiella quasivariicola was a novel strain of Klebsiella species and had potential pathogenicity. Our previously studies showed dopamine, one of the most commonly used rescue drugs for critically ill patients, had clear effects on the growth of K. quasivariicola in culture medium, however, its effects on host immune system were ignored. Therefore, in consideration of the host immunity, the interactions of K. quasivariicola, dopamine and macrophages were explored. In this study, RAW264.7 cells and C57/BL6 mice were infected with K. quasivariicola, and the bacterial growth in macrophage, the production of inflammatory cytokines and the pathological changes of mice lung were detected, in the absence or presence of dopamine. Our results showed dopamine inhibited the K. quasivariicola growth in medium, but promoted the bacterial growth when K. quasivariicola was co-cultured with macrophages; The expression of proinflammatory cytokines in K. quasivariicola infected RAW 264.7 were increased, while a sharp rise was observed with the addition of dopamine; Infection of K. quasivariicola to mice induced an inflammatory response and lung injury, which were exacerbated by dopamine administration. It can be concluded that dopamine administration resulted in a significantly increase of K. quasivariicola burdens in the presence of macrophage, consequently, aggravated the inflammatory response and inflammatory injury.

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Antibacterial Activity of Halophilic Bacteria Against Drug-Resistant Microbes Associated with Diabetic Foot Infections

Cited by 17 publications

References 37 publications

Recent Antimicrobial Responses of Halophilic Microbes in Clinical Pathogens

Recent Antimicrobial Responses of Halophilic Microbes in Clinical Pathogens

In-vitro Antibacterial and Antifungal Activity of Curcuma Amada Roxb. against Human Pathogens

Dopamine promotesKlebsiella quasivariicolaproliferation and inflammatory response in the presence of macrophages

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