In-vitro Antibacterial and Antifungal Activity of Curcuma Amada Roxb. against Human Pathogens

Kashyap, Nand Kumar; Deepak, Jeetendra; Bhardwaj, Arvind Kumar; Hait, Milan; Pal, Dilipkumar

doi:10.48048/tis.2022.4839

Cited by 11 publications

(1 citation statement)

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“…After the extraction, the solution is dried in hot air oven. Then the semi solid slurry is added to Eppendorf and stored at 4 °C 11,6,12 .…”

Section: Fig 2: Cold Extraction Using Ethanol and Distilled Water As ...mentioning

confidence: 99%

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2024

IJPSR

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The increasing resistance of microorganisms to conventional antibiotics has prompted scientists to explore alternative sources for antimicrobial compounds. This study focuses on Curcuma amada, a perennial herb, and its rhizome extracts for antibacterial activity against major bacterial strains identified in burn wounds: Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Various extraction methods like Cold extraction, Microwave Assisted Extraction and Soxhlet Extraction were employed to obtain ethanolic and aqueous extracts and their effectiveness was evaluated through Minimal Inhibitory Concentration (MIC) testing. MIC, crucial in determining antimicrobial potency, revealed that the extract inhibited visible bacterial growth at a concentration of 100μg/ml for all tested organisms. This concentration was identified by a colour change from violet to pink, signifying the absence of observable microbial growth. Diverse medicinal properties of Curcuma amada, including antiinflammatory, digestive, and febrifuge effects, present a promising avenue for developing natural antimicrobial agents. The findings suggest that these plant extracts possess potential as safe alternatives or complementary treatments in managing burn wounds. This research highlights the importance of exploring plant-derived compounds as a response to the urgent need for novel antimicrobial solutions against increasingly resistant microorganisms, particularly in the context of treating infectious diseases and wounds. INTRODUCTION:Infectious diseases are the leading cause of death world-wide. Antibiotic resistance has become a global concern 1 . The flora of the burn wound also influence the risk of infection and the invasive potential of infections that do occur.

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“…After the extraction, the solution is dried in hot air oven. Then the semi solid slurry is added to Eppendorf and stored at 4 °C 11,6,12 .…”

Section: Fig 2: Cold Extraction Using Ethanol and Distilled Water As ...mentioning

confidence: 99%