Antibacterial Activity of Bismuth Oxide Nanoparticles Compared to Amikacin against Acinetobacter baumannii and Staphylococcus aureus

Abstract

In this work, bismuth oxide nanoparticles (Bi2O3 NP) were prepared by laser ablation of a solid target in distilled water. The optical and structural properties of Bi2O3 NPs were studied using UV–VIS spectroscopy, energy-dispersive X-ray spectroscopy (EDS), transmission electron microscope (TEM), scanning electron microscopy (SEM), and Fourier transform infrared (FTIR). The results showed that the average particle size is less than 20 nm. The antibacterial activity of the Bi2O3 NPs was determined and compared with amikacin against Acinetobacter baumannii and Staphylococcus aureus. The activity of Bi2O3 NPs was higher than the amikacin. Furthermore, the antibacterial activity of Bi2O3 NPs against S. aureus bacteria was higher than Acinetobacter baumannii; this result was confirmed by studying the effect of Bi2O3 NPs in bacterial biofilm formation in eyes contact lenses using atomic force microscopy (AFM) technique. Taken together, Bi2O3 NPs could be used as a preservative for contact lenses as eye drops to prevent the formation of microbial biofilms in contact lenses.

Antibacterial efficacy of novel bismuth-silver nanoparticles synthesis on Staphylococcus aureus and Escherichia coli infection models

“…In addition, Bi/Ag NPs inhibit biofilm formation and prevent the appearance of chronic infections. Notably, the MBC of Bi/Ag NPs on bacteria studied is up to 100 times lower than those reported by other studies, where the antibacterial effect of bismuth and silver nanoparticles on in vitro models was evaluated ( Kovacevic et al, 2011 ; Lange et al, 2021 ; Jawad et al, 2022 ).…”

A novel method for ZnO@NiO core–shell nanoparticle synthesis using pulse laser ablation in liquid and plasma jet techniques

“…On the contrary, Gram-positive bacteria have a simple structure with a membrane surrounding the cell as well as a cell wall composed primarily of a peptidoglycan layer and teichoic and lipoteichoic acids. Therefore, the inhibition zone in Gram-positive bacteria is larger than that in Gram-negative bacteria 54 . Damage to cell membranes was caused by direct contact with NPs.…”

Antioxidant and Antibacterial Activities of Allium sativum Ethanol Extract and Silver Nanoparticles

“…5,18 There are many studies to find alternative drugs to kill pathogenic bacteria or inhibit some of virulence factors. [20][21][22][23][24] The antibacterial activity could also be linked to the fact that cells have largely sulfur and phosphorous, which are smooth sources, and DNA is mostly sulfur and phosphorous. AgNPs can act on these sensitive sources and destroy DNA, causing cell death.…”