Antibacterial activity and mechanism of action of some Iranian honeys compared to manuka honey against multidrug-resistant respiratory and urinary infections

Moghadam, Mohadese Naghadian; Khaledi, Elahe Mahmoodi

doi:10.1016/j.fbio.2021.101003

Cited by 8 publications

(5 citation statements)

References 35 publications

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“…As for the kinetics of the antibacterial activity, time-kill studies revealed that our honey samples started inhibiting bacterial growth between 6 and 8 h of incubation both for P. aeruginosa and S. pneumoniae, similarly to a recent study performed with Iranian honeys and P. aeruginosa [73].…”

Section: Discussionsupporting

confidence: 86%

“…Our findings are in accordance with Awan and co-workers’ results regarding the anti- Pseudomonas activity of sunflower honey, which was, however, inferior compared to the effect of eucalyptus honey [ 70 ]. Manuka ( Leptospermum scoparium ) honey proved to be effective against P. aeruginosa both in antibacterial and antibiofilm assays [ 71 , 72 , 73 ]. In addition, clover ( Trifolium sp.…”

Section: Discussionmentioning

confidence: 99%

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In Vitro Antibacterial and Antibiofilm Activity of Hungarian Honeys against Respiratory Tract Bacteria

Balázs

Nagy-Radványi

Filep

et al. 2021

Foods

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Honey is a rich source of carbohydrates, while minor compounds such as amino acids and polyphenols contribute to its health-promoting effects. Honey is one of the oldest traditional remedies applied for microbial infections, due to its antibacterial, anti-inflammatory, and antioxidant properties. The aim of this study was to investigate the antibacterial and antibiofilm effects of Hungarian black locust, linden, and sunflower honeys against the most common biofilm-forming respiratory tract pathogens Haemophilus spp., Pseudomonas aeruginosa, and Streptococcus pneumoniae. The unifloral character of all three honey types was confirmed by melissopalynological analysis. The antibacterial activity of each honey sample against each bacterium strain was proven with agar well diffusion assay and thin layer chromatography—direct bioautography. Kinetics and mechanisms of antibacterial action were clarified with time-kill assay and membrane degradation study. The anti-biofilm activity was evidenced using crystal violet assay. In each assay, linden honey was the most effective, followed by sunflower and black locust honey. In addition, each honey sample had greater potential to suppress respiratory tract bacteria, compared to major sugar components. In conclusion, honey in general and linden honey in particular, can have a role in the treatment of respiratory tract infections caused by biofilm-forming bacteria.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

In Vitro Antibacterial and Antibiofilm Activity of Hungarian Honeys against Respiratory Tract Bacteria

Balázs

Nagy-Radványi

Filep

et al. 2021

Foods

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“…Manuka promoted efflux pumps blockade in dose‐dependent way, that further caused remarkable metabolic disruption by compromising the cell membrane potential and integrity. This has a subsequent effect on cell morphological changes (shrinkage or enlargement) that might result to cell death due to the mismatch in surface‐to‐volume ratio (Moghadam & Khaledi, 2021). MRSA strains treated with 50% of Manuka UMF15+ were PI + at a range of 68%–91%, with a few exceptions that might be related to a strain resistance.…”

Section: Resultsmentioning

confidence: 99%

The antimicrobial mechanism of Greek thyme honeys against methicillin‐resistant Staphylococcus aureus clinical isolates: a case study of comparison with Manuka honey

Masoura

Gkatzionis

2022

Int J of Food Sci Tech

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Summary The antibacterial potential of honey has been of great scientific interest. Understanding the underlying mechanism is essential to explore its potential as therapeutic alternative against a range of (non)pathogenic microorganisms. The floral origin of honey is critical for its antibacterial activity and Greek thyme honeys have been of increasing interest due to their chemical composition and bioactivity. In this study, the antimicrobial effect of six Greek honeys, with different percentages of thyme pollen grains and two Manuka honeys were tested against four MRSA clinical isolates (ATCC 43300, 0791, 28965, 01322). Agar‐well diffusion assay and total viable counts were used to examine the antimicrobial strength of honeys, while the effect thereof on cellular redox state and cell membrane was tested by flow cytometry. Thyme honeys had superior or equal antimicrobial strength compared to this of Manuka, while thermal processing did not significantly affect this activity. Acidity and the high H2O2 content, common features for all thyme honeys, caused cellular oxidative damage and cell death unlike observed in Manuka‐treated populations. The activity of the monofloral thyme honey (74% thyme pollen) was higher than the other indigenous polyfloral samples, which confirms the medicinal importance of this medicinal plant.

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“…For the last few decades, preclinical investigations have been conducted to explore the therapeutic capacity of honey. Antimicrobial, antiseptic, and wound healing activities of honey are well documented in many literatures, in addition, it has antioxidant, anti-inflammatory, immuneboosting and antitumor agents potential [93,94]. Physical and chemical properties of honey such as low water content, high acidity, high permeability and the existence of hydrogen peroxide may be responsible for the bactericidal property of honey, while the components of honey, such as simple sugars, vitamins, minerals, enzymes, and antioxidants (i.e., phenolic and flavonoids) render its nutritional benefits.…”

Section: Health Benefits and Mechanistic Profiles Of Honeymentioning

confidence: 99%

Neuroprotective Potentials of Honey for Cerebral Small Vessel Disease

Mustapha¹,

Ismail²,

Mehat³

et al. 2022

OBM Neurobiol

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The nectar produced by bees in nature is known as honey and has been consumed for its nutritional and medicinal properties. There is growing evidence that honey and its compounds have anti-inflammatory, antioxidant and anti-microbial properties that are relevant to the maintenance of health and the prevention of illnesses, including cardiocerebrovascular disease. Cerebral small vessel disease (CSVD) is one of the major risk factors for diseases such as stroke, dementia, Alzheimer’s disease, and Parkinson’s disease. CSVD is prevalent with aging and the presence of vascular risk factors. Its most common deleterious effect on the brain parenchyma is a neurological problem, causing a spectrum of subtle clinical manifestations such as neurocognitive dysfunction, emotional or behavioral disturbances, and gait dysfunction. Moreover, the pathological mechanisms and preventive strategies for CSVD remain elusive, which is reflected in the continued lack of effective therapeutic and preventive therapies. Given the growing literature on honey and its compounds as a superfood-based preventive measure, this narrative review highlights the neuroprotective potentials of honey and its compounds in relation to the current understanding of CSVD pathomechanism.

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Antibacterial activity and mechanism of action of some Iranian honeys compared to manuka honey against multidrug-resistant respiratory and urinary infections

Cited by 8 publications

References 35 publications

In Vitro Antibacterial and Antibiofilm Activity of Hungarian Honeys against Respiratory Tract Bacteria

In Vitro Antibacterial and Antibiofilm Activity of Hungarian Honeys against Respiratory Tract Bacteria

The antimicrobial mechanism of Greek thyme honeys against methicillin‐resistant Staphylococcus aureus clinical isolates: a case study of comparison with Manuka honey

Neuroprotective Potentials of Honey for Cerebral Small Vessel Disease

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