The antimicrobial mechanism of Greek thyme honeys against methicillin‐resistant <i>Staphylococcus aureus</i> clinical isolates: a case study of comparison with Manuka honey

Masoura, Maria; Gkatzionis, Konstantinos

doi:10.1111/ijfs.16045

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…In addition, Voidarou et al [19] evaluated the therapeutic properties of oregano honey against gastric ulcers and gastritis caused by Helicobacter pylori, pointing out that diethyl ether extracts of the honey and the honey itself reduced urease activity exhibited by the specific pathogen. Moreover, Masoura and Gkatzionis [20] examined possible antimicrobial effects of thyme and Manuka honeys against methicillin-resistant Staphylococcus aureus (MRSA) strains. The low pH and the high H 2 O 2 concentration were the key factors influencing the antibacterial activity of monofloral thyme honey.…”

Section: Introductionmentioning

confidence: 99%

Microbial Community Structure among Honey Samples of Different Pollen Origin

et al. 2023

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Honey’s antibacterial activity has been recently linked to the inhibitory effects of honey microbiota against a range of foodborne and human pathogens. In the current study, the microbial community structure of honey samples exerting pronounced antimicrobial activity was examined. The honey samples were obtained from different geographical locations in Greece and had diverse pollen origin (fir, cotton, fir–oak, and Arbutus unedo honeys). Identification of honey microbiota was performed by high-throughput amplicon sequencing analysis, detecting 335 distinct taxa in the analyzed samples. Regarding ecological indices, the fir and cotton honeys possessed greater diversity than the fir–oak and Arbutus unedo ones. Lactobacillus kunkeei (basionym of Apilactobacillus kun-keei) was the predominant taxon in the fir honey examined. Lactobacillus spp. appeared to be favored in honey from fir-originated pollen and nectar since lactobacilli were more pronounced in fir compared to fir–oak honey. Pseudomonas, Streptococcus, Lysobacter and Meiothermus were the predominant taxa in cotton honey, whereas Lonsdalea, the causing agent of acute oak decline, and Zymobacter, an osmotolerant facultative anaerobic fermenter, were the dominant taxa in fir–oak honey. Moreover, methylotrophic bacteria represented 1.3–3% of the total relative abundance, independently of the geographical and pollen origin, indicating that methylotrophy plays an important role in honeybee ecology and functionality. A total of 14 taxa were identified in all examined honey samples, including bacilli/anoxybacilli, paracocci, lysobacters, pseudomonads, and sphingomonads. It is concluded that microbial constituents of the honey samples examined were native gut microbiota of melliferous bees and microbiota of their flowering plants, including both beneficial bacteria, such as potential probiotic strains, and animal and plant pathogens, e.g., Staphylococcus spp. and Lonsdalea spp. Further experimentation will elucidate aspects of potential application of microbial bioindicators in identifying the authenticity of honey and honeybee-derived products.

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Section: Introductionmentioning

confidence: 99%

Microbial Community Structure among Honey Samples of Different Pollen Origin

et al. 2023

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“…While most attention has focused on manuka (Leptospermum) honey, various non-manuka honeys, including European honeys, have been shown to have good antimicrobial activity (e.g. [29][30][31]). Medical honey and honey-impregnated dressings are a common line of care for wound management in clinical settings, including treatment for biofilms, critically colonized wounds and infections with high bacterial levels, chronic ulceration, debridement of dead tissue, malodorous wounds, fungating wounds, burn sites, skin grafts and surgical wounds [32 -34].…”

Section: Introductionmentioning

confidence: 99%

Sweet and sour synergy: exploring the antibacterial and antibiofilm activity of acetic acid and vinegar combined with medical-grade honeys

et al. 2023

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Oxymel, a combination of honey and vinegar, has been used as a remedy for wounds and infections in historical and traditional medical settings. While honey is now clinically used to treat infected wounds, this use of a complex, raw natural product (NP) mixture is unusual in modern western medicine. Research into the antimicrobial activity of NPs more usually focuses on finding a single active compound. The acetic acid in vinegar is known to have antibacterial activity at low concentrations and is in clinical use to treat burn wound infections. Here, we investigated the potential for synergistic activity of different compounds present in a complex ingredient used in historical medicine (vinegar) and in an ingredient mixture (oxymel). We conducted a systematic review to investigate published evidence for antimicrobial effects of vinegars against human pathogenic bacteria and fungi. No published studies have explicitly compared the activity of vinegar with that of a comparable concentration of acetic acid. We then characterized selected vinegars by HPLC and assessed the antibacterial and antibiofilm activity of the vinegars and acetic acid, alone and in combination with medical-grade honeys, against Pseudomonas aeruginosa and Staphylococcus aureus . We found that some vinegars have antibacterial activity that exceeds that predicted by their acetic acid content alone, but that this depends on the bacterial species being investigated and the growth conditions (media type, planktonic vs. biofilm). Pomegranate vinegars may be particularly interesting candidates for further study. We also conclude that there is potential for acetic acid, and some vinegars, to show synergistic antibiofilm activity with manuka honey.

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The Therapeutic Mechanisms of Honey in Mitigating Toxicity from Anticancer Chemotherapy Toxicity: A Review

Bose,

Famurewa,

Akash

et al. 2024

JoX

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Within the domain of conventional oncochemotherapeutics, anticancer chemotherapy (AC) has emerged as a potent strategy for the treatment of cancers. AC is the mainstay strategy for solid and non-solid cancer treatment. Its mechanistic action targets the blockage of DNA transcription and the dysregulation of cell cycle machinery in cancer cells, leading to the activation of death pathways. However, the attendant side effect of toxicity inflicted by AC on healthy tissues presents a formidable challenge. The crucial culprit in the AC side effect of toxicity is unknown, although oxidative stress, mitochondrial impairment, inflammatory cascades, autophagy dysregulation, apoptosis, and certain aberrant signaling have been implicated. Honey is a natural bee product with significant health benefits and pharmacological properties. Interestingly, the literature reports that honey may proffer a protection mechanism for delicate tissue/organs against the side effect of toxicity from AC. Thus, this review delves into the prospective role of honey as an alleviator of the AC side effect of toxicity; it provides an elucidation of the mechanisms of AC toxicity and honey’s molecular mechanisms of mitigation. The review endeavors to unravel the specific molecular cascades by which honey orchestrates its mitigating effects, with the overarching objective of refining its application as an adjuvant natural product. Honey supplementation prevents AC toxicity via the inhibition of oxidative stress, NF-κB-mediated inflammation, and caspase-dependent apoptosis cascades. Although there is a need for increased mechanistic studies, honey is a natural product that could mitigate the various toxicities induced by AC.

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The antimicrobial mechanism of Greek thyme honeys against methicillin‐resistant Staphylococcus aureus clinical isolates: a case study of comparison with Manuka honey

Cited by 3 publications

References 29 publications

Microbial Community Structure among Honey Samples of Different Pollen Origin

Microbial Community Structure among Honey Samples of Different Pollen Origin

Sweet and sour synergy: exploring the antibacterial and antibiofilm activity of acetic acid and vinegar combined with medical-grade honeys

The Therapeutic Mechanisms of Honey in Mitigating Toxicity from Anticancer Chemotherapy Toxicity: A Review

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