Antibacterial activity and mechanism of cinnamic acid and chlorogenic acid against <i>Alicyclobacillus acidoterrestris</i> vegetative cells in apple juice

Cai, Rui; Miao, Miao; Yue, Tianli; Zhang, Yijun; Chen, Lu; Wang, Zhouli; Yuan, Yahong

doi:10.1111/ijfs.14051

Cited by 54 publications

(40 citation statements)

References 35 publications

(38 reference statements)

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“…The antibacterial activity of L. pentosus lacidophilin was carried out utilizing the agar diffusion method according to the previous report (Cai et al, 2019) with minor modifications: MRS medium (10 ml) containing 2% agar was used as the bottom plate. MRS medium (7 ml) containing 0.7% agar and 5% indicator bacteria cell suspension (OD 600 , 0.6) was poured on the bottom plate as the upper plate.…”

Section: Antibacterial Activity Measurementmentioning

confidence: 99%

“…The total protein content of the L. p. supernatant was detected with the Coomassie Brilliant Blue G-250 dye method according to the report by Cai et al (2019). The L. p. supernatant (1 ml) was mixed with 5 ml of Coomassie Brilliant Blue G-250 dye and laid for 2 min.…”

Section: Antibacterial Activity Measurementmentioning

confidence: 99%

“…Leakage of the soluble nucleic acids was detected according to the method by Cai et al (2019) with minor modification. The indicator bacterial suspension (20 ml, OD 600 , 0.9) was mixed with an equal volume of L. p. supernatant and incubated at 37 • C for 0, 1.5, 3, 5, and 7 h, respectively.…”

Section: Effect Of Lacidophilin On Cell Membrane Permeabilitymentioning

confidence: 99%

“…SDS-PAGE was carried out to measure the bacteria cell protein changes according to the method by Cai et al (2019) with some modifications. The indicator bacterial suspension (4 ml, OD 600 , 0.6) was mixed with an equal volume of L. p. supernatant and incubated at 37 • C for 18 h. Then, 5 ml of the inoculum was taken out and centrifuged at 8,000 × g for 15 min at 4 • C to collect the precipitate.…”

Section: Effect Of Lacidophilin On Bacterial Proteinmentioning

confidence: 99%

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Antibacterial Activity and Mechanism of Lacidophilin From Lactobacillus pentosus Against Staphylococcus aureus and Escherichia coli

Zhu

Zhang

2020

Front. Microbiol.

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The main purpose of this study was to explore the antibacterial activity and mechanism of lacidophilin from Lactobacillus pentosus against Staphylococcus aureus and Escherichia coli. The effects of temperature, enzyme, metal ions, and pH on the antibacterial activity of L. pentosus were evaluated. The result showed that lacidophilin had good thermal stability and could be decomposed by trypsin completely. The antibacterial ability was affected by high concentration of metal ions, and the best antibacterial ability was acquired under acidic conditions. The antibacterial mechanism of lacidophilin was explored through studying cytomembrane injury, phosphorus metabolism, protein changes, and oxidative stress response of the indicator bacteria. It was shown that lacidophilin destroyed the cytomembrane of the bacteria and increased the cytomembrane permeability, which resulted in the leak of proteins, nucleic acids, and electrolytes. In addition, it further restrained phosphorus metabolism, caused changes of some protein contents, and increased cytomembrane lipid peroxidation and cell oxidative damage. All these might inhibit the growth of bacteria and even cause their death. This study identified a natural biological preservative with strong antibacterial activity against both Gram-positive and Gram-negative foodborne pathogens. The high antibacterial activity against the two types of bacteria reflected its potential in food preservation used as a natural food preservative.

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Section: Antibacterial Activity Measurementmentioning

confidence: 99%

Section: Antibacterial Activity Measurementmentioning

confidence: 99%

Section: Effect Of Lacidophilin On Cell Membrane Permeabilitymentioning

confidence: 99%

Section: Effect Of Lacidophilin On Bacterial Proteinmentioning

confidence: 99%

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Antibacterial Activity and Mechanism of Lacidophilin From Lactobacillus pentosus Against Staphylococcus aureus and Escherichia coli

Zhu

Zhang

2020

Front. Microbiol.

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“…Depending on their therapeutic targets, different modes of action seem to be exerted by CA and their derivatives or analogues. For instance, interactions with pathogens' membranes have been associated with the antimicrobial action of CA [30][31][32], whereas anticancer properties of different CA have been related to apoptosis [33][34][35][36][37][38][39], which encompasses various events including "S"-cycle arrest [34], cytoskeleton disruption [37], activation of caspases [38], generation of reactive oxygen species (ROS) [35,36], and inhibition of histone deacetylases [33,39].…”

Section: Introductionmentioning

confidence: 99%

Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs

et al. 2019

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Cinnamic acids are compounds of natural origin that can be found in many different parts of a wide panoply of plants, where they play the most diverse biological roles, often in a conjugated form. For a long time, this has been driving Medicinal Chemists towards the investigation of the therapeutic potential of natural, semi-synthetic, or fully synthetic cinnamic acid conjugates. These efforts have been steadily disclosing promising drug leads, but a wide chemical space remains that deserves to be further explored. Amongst different reported approaches, the combination or conjugation of cinnamic acids with known drugs has been addressed in an attempt to produce either synergistic or multi-target action. In this connection, the present review will focus on efforts of the past decade regarding conjugation with cinnamic acids as a tool for the rescuing or the repurposing of classical antimalarial drugs, and also on future perspectives in this particular field of research.

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Pomegranate peel: Bioactivities as antimicrobial and cytotoxic agents

Abu‐Niaaj,

Al‐Daghistani,

Katampe

et al. 2024

Food Science & Nutrition

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This is a comparative study to evaluate the effectiveness of six pomegranate peel extracts (PPEs) as antibacterial and antiproliferative agents. The Six PPEs were prepared using four solvent systems and each filtrate was concentrated to a gummy material to be used in the evaluation. The well‐diffusion method was used to evaluate their antimicrobial activity against bacteria typically associated with food spoilage: Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Listeria monocytogenes, Staphylococcus epidermidis, Staphylococcus aureus, and three Bacillus species. The 3‐(4,5‐dimethylthiazol‐2‐yl)‐5‐(3‐carboxymethoxyphenyl)‐2‐(4‐sulfophenyl)‐2H‐tetrazolium (MTT) was used to evaluate the cytotoxicity against colorectal carcinoma cells (HCT116), prostate adenocarcinoma (PC3), ovarian cancer cells (SKOV‐3), and fibroblasts (MRC‐5). The antioxidant evaluation was done using the 2,2‐diphenyl‐1‐picrylhydrazyl‐hydrate (DPPH) assay. The pH of the water‐containing extracts was acidic and almost the same over 6 weeks. The six PPEs inhibited the bacterial growth in a comparable level to standard antibiotics. The effectiveness of each extract was dependent on the bacterial strain, and the Listeria showed a remarkable inhibition when exposed to the aqueous extract prepared at room temperature (RT). The aqueous (RT) and methanol PPEs had a significant antioxidant scavenging capability and a remarkable cytotoxic activity against the PC3 with half maximal inhibitory concentration (IC50) of 0.1 μg/mL. The boiled aqueous extract exhibited antiproliferative activity against HCT116 with an IC50 of 21.45 μg/mL. The effect on SKOV‐3 and fibroblasts was insignificant. With the exception of butanol, the antioxidant screening shows an inverse correlation between the polarity of the extraction solvent and the IC50 exhibited by the PPEs. The variation in the effectiveness of PPEs is suggested to be due to variable soluble bioactive compounds that may interact differently with different cells, though water‐containing extracts are promising antibacterial agents. The findings clearly show that pomegranate peel possessed the potential to be an eco‐friendly novel source for natural compounds that can be implemented in the food industry as a natural antimicrobial and natural food additive to prevent foodborne illnesses.

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Antibacterial activity and mechanism of cinnamic acid and chlorogenic acid against Alicyclobacillus acidoterrestris vegetative cells in apple juice

Cited by 54 publications

References 35 publications

Antibacterial Activity and Mechanism of Lacidophilin From Lactobacillus pentosus Against Staphylococcus aureus and Escherichia coli

Antibacterial Activity and Mechanism of Lacidophilin From Lactobacillus pentosus Against Staphylococcus aureus and Escherichia coli

Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs

Pomegranate peel: Bioactivities as antimicrobial and cytotoxic agents

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