Antibacterial Activities of Some Schiff Bases Involving Thiosemicarbazide and Ketones

Abstract

Three Schiff bases derived from thiosemicarbazide and ketones (Vanillin, Benzophenone and Acetophenone) were used to study their antibacterial activities against some pathogenic bacteria by disc diffusion method. Of these, benzophenone thiosemicarbazone showed significant antibacterial activity as compared with that of Kanamycin. All these three compounds were found to possess cytotoxic effect. Minimum inhibitory concentration of these compounds was also determined.

Solvent free synthesis of hydrazine carbothioamide derivatives as a precursor in the preparation of new mononuclear Mn(II), Cu(II), and Zn(II) complexes: Spectroscopic characterizations

“…The chemistry of Schiff base transition metal complexes has become highly attractive due to their wide pharmacokinetic profile providing a variety of compounds with different activities [11][12][13][14][15]. In recent years, the distinguish ligands containing sulfur atom such as thiosemicarbazones derivatives and their complexes with some of transition metal ions have a great attention in the field of medicinal chemistry according to their therapeutic importance, such as anti-bacterial, anti-fungal, anti-viral, anti-allergic, anti-tumor, anticancer, and anti-HIV activities [16][17][18][19][20][21][22][23][24][25][26][27][28]. Based on these vital items, herein we reported the synthesis and spectroscopic characterization of two new Schiff base complexes of 2-(2-hydroxy-3-methoxybenzylidene) hydrazinecarbothioamide derivatives ligands with manganese(II), copper(II), and zinc(II) metal ions.…”

Synthesis, Spectral and Thermal Characterization on Bioactive Complexes of Mg(II), Zn(II), Sn(II), VO(II) and Bi(III) Ions Containing Schiff Base Ligand

“…The central metal ions in these complexes turn as active sites for pharmacological agent [4][5][6] . Schiff bases and their metal complexes are also well known to have prominent biological action and form vital class of compounds in medicine and pharmaceutical field also showed some degree of antibacterial, antifungal, antitumor, anticancer and anti-inflammatory activity [7][8][9][10][11] . The azomethine linkage is responsible for the biological activity of Schiff bases.…”

Selected Pharmacological Applications of 1<sup>st</sup> Row Transition Metal Complexes: A review

“…Nowadays, the bioinorganic chemists target the heterocyclic ligands and their metal complexes to study their pharmacology as the main focus of research [9][10]. A wide range of biological activities [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] such as antibacterial, antifungal, antitumor, anti-HIV [31] and antiviral activities are exhibited by the nitrogen-containing organic compounds and their metal complexes. Transition metal complexes offer two distinct advantages as DNA-binding agents [32].…”