Antibacterial activities of ethanol extracts of Philippine medicinal plants against multidrug-resistant bacteria

Valle, Demetrio L.; Andrade, Jeannie I; Puzon, Juliana Janet M.; Cabrera, Esperanza C.; Rivera, Windell L.

doi:10.1016/j.apjtb.2015.04.005

Cited by 107 publications

(78 citation statements)

References 40 publications

(40 reference statements)

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“…Due to the increased microbial resistance against antibiotics and antiseptics as well as the high treatment costs, there have been adequate motives to search for alternative remedies to overcome this issue (Valle et al 2015;Gupta and Birdi 2017).…”

Section: Discussionmentioning

confidence: 99%

Benefits of sea buckthorn (Hippophae rhamnoides) pulp oil‐based mouthwash on oral health

Smida

Pentelescu

et al. 2019

J Appl Microbiol

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Aim The purpose of this study was to conduct phytochemical analysis of sea buckthorn pulp oil and to evaluate the antimicrobial, anti‐biofilm and antioxidant activities of its mouthwash form. Methods and Results Fatty acid composition of the sea buckthorn pulp oil was determined by GC‐MS analysis, which revealed that, mono‐unsaturated fatty acid, palmitoleic acid and saturated fatty acid, palmitic acid, were the major constituents. The antimicrobial and the anti‐biofilm capacities of sea buckthorn pulp oil mouthwash form were evaluated against Streptococcus gordonii, Porphyromonas gingivalis, Actinomyces viscosus and Candida albicans, according to the European Norms, and the Biofilm Ring Test®, respectively. These activities were then compared with those of chlorhexidine and herbal mouthwashes. The sea buckthorn‐based mouthwash was bactericidal against S. gordonii and P. gingivalis, bacteriostatic against A. viscosus and showed no antifungal effect. Regardless of the strains used, complete inhibition of biofilm formation was achieved. The antioxidant activity of this experimental mouthwash was also assessed by DPPH and NBT assays. Conclusion Sea buckthorn mouthwash showed anti‐biofilm activities against select single and multiple oral bacterial species. Significance and Impact of the Study In this study, a mouthwash derived from sea buckthorn (Hippophae rhamnoides) pulp oil has been experimented, for the first time, in order to overcome the problem of a large number of available synthetic mouthwashes which have side effects on teeth, gums and mucous membranes. This mouthwash seemed to be a suitable alternative for a preventive agent for periodontal inflammation.

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Section: Discussionmentioning

confidence: 99%

Benefits of sea buckthorn (Hippophae rhamnoides) pulp oil‐based mouthwash on oral health

Smida

Pentelescu

et al. 2019

J Appl Microbiol

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“…In a recent study on multi‐drug resistant bacteria, crude ethanol extract of P. niruri was tested and found to inhibit methicillin‐resistant St. aureus and vancomycin‐resistant Enterococcus (Valle et al , ).…”

Section: Pharmacological Studies In Phyllanthus Niruri Lmentioning

confidence: 99%

Phytochemistry and Pharmacology of Phyllanthus niruri L.: A Review

Kaur

Sirhindi

2017

Phytotherapy Research

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Phyllanthus niruri, a typical member of family Euphorbiaceae, is a small annual herb found throughout the tropical and subtropical regions of both hemispheres. The genus Phyllanthus has been used in traditional medicine for its wide range of pharmacological activities like antimicrobial, antioxidant, anticancer, antiinflammatory, antiplasmodial, antiviral, diuretic and hepatoprotective. This review summarizes the information about morphological, biochemical, ethanobotanical, pharmacological, biological and toxicological activities with special emphasis on mechanism of anticancer activity of P. niruri. Gaps in previous studies such as taxonomic inconsistency of P. niruri, novel phytochemicals and their therapeutic properties, especially mechanisms of anticancerous activity and market products available, have been looked into and addressed. Scientific information related to 83 phytochemicals (including many novel compounds detected recently by the authors) has been provided in a very comprehensive manner. Copyright © 2017 John Wiley & Sons, Ltd.

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“…The field of animal nutrition can contribute to limiting the recrudescence of antimicrobial resistances by exploring nutritional alternatives to antibiotics that prevent microbial infections. Some plants are known as nutraceuticals because they exhibit antimicrobial properties for both susceptible and multiresistant-drug bacteria [7]. It has been demonstrated in vitro that polyphenol-rich plants can disrupt ETEC adhesion and inhibit some enterotoxins, including the LT from ETEC [8, 9].…”

Section: Introductionmentioning

confidence: 99%

Chestnut extract but not sodium salicylate decrease the severity of diarrhea and enterotoxigenic Escherichia coli F4 shedding in artificially infected piglets

Girard

Pradervand

et al. 2019

Preprint

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19The development of alternatives to antibiotics is crucial to limiting the incidence of antimicrobial 20 resistance, especially in prophylactic and metaphylactic use to control post-weaning diarrhea 21 (PWD). Feed additives, including bioactive compounds, could be a promising alternative. This 22 study aimed to test two bioactive compounds, sodium salicylate (SA) and a chestnut extract 23 (CE) containing hydrolysable tannins, on the occurrence of PWD. At weaning, 72 piglets were 24 assigned to four treatments that combined two factors: CE supplementation (with 2% of CE 25 (CE+) or without (CE-)) and SA supplementation (with 35 mg/kg BW of SA (SA+) or without 26 (SA-)). Then, 4 days after weaning, all piglets were infected with a suspension at 10 8 CFU/ml 27 of enterotoxigenic Escherichia coli (ETEC F4ac). Each piglet had free access to an electrolyte 28 solution containing, or not, SA. This SA supplementation was administered for 5 days (i.e., 29 from the day of infection (day 0) to 4 days post-infection (day 4). During the 2 weeks post-30 infection, supplementation with SA had no effect (P > 0.05) on growth performances nor on 31 fecal scores. A significant SA × time interaction (P < 0.01) for fecal scores and the percentage 32 of diarrhea indicated that piglets with SA did not recover faster and did have a second episode 33 of diarrhea. In contrast to SA treatment, inclusion of CE increased (P < 0.05) growth 34 performances and feed intake. In the first week post-infection, CE decreased (P < 0.001) the 35 overall fecal scores, the percentage of piglets with diarrhea, the days in diarrhea, and ETEC 36 shedding in the feces. There was a SA×CE interaction (P < 0.05) for ETEC shedding, 37 suggesting a negative effect of combining SA with CE. This study highlighted that, in contrast 38 to SA, CE could represent a promising alternative to antibiotics immediately after weaning for 39 improving growth performance and reducing PWD. 41 Post-weaning diarrhea (PWD) is a major enteric disease in pig production that occurs mainly 42 during the first two weeks after weaning. This problem causes substantial economic losses 43 due to high rates of mortality and morbidity, depression of feed intake and growth, and 44 increased costs of medication [1]. 45 Apart from the multifactorial etiology owing to several stressors, including nutritional, social, 46 and environmental changes, PWD is often related to infection with specific pathogens. 47 Enterotoxigenic Escherichia coli (ETEC) is a prevalent pathogen involved in PWD [2]. For 48 instance, in Switzerland, 42.5% of weaned pigs with diarrhea were identified as having ETEC 49 [3]. Those bacteria possess fimbriae that adhere to receptors located on the apical side of the 50 enterocytes and secrete enterotoxins, including heat labile toxin (LT) and heat stable toxin 51 (STb), which results in fluid secretion into the intestinal lumen, leading to dehydration and 52 acidosis, which ultimately results in diarrhea [4, 5]. 53 Antibiotics are usually used to treat this type of infection....

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Antibacterial activities of ethanol extracts of Philippine medicinal plants against multidrug-resistant bacteria

Cited by 107 publications

References 40 publications

Benefits of sea buckthorn (Hippophae rhamnoides) pulp oil‐based mouthwash on oral health

Benefits of sea buckthorn (Hippophae rhamnoides) pulp oil‐based mouthwash on oral health

Phytochemistry and Pharmacology of Phyllanthus niruri L.: A Review

Chestnut extract but not sodium salicylate decrease the severity of diarrhea and enterotoxigenic Escherichia coli F4 shedding in artificially infected piglets

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