Antibacterial action of lipid nanocapsules containing fatty acids or monoglycerides as co-surfactants

Umerska, Anita; Cassisa, Viviane; Matougui, Nada; Joly-Guillou, Marie-Laure; Eveillard, Matthieu; Saulnier, Patrick

doi:10.1016/j.ejpb.2016.09.001

Cited by 54 publications

(52 citation statements)

References 49 publications

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“…The size of these LNC was 51 ± 12 nm with PDI < 0.3 and stable for 18 months on storage at 4°C and 1.5 months at 37°C. The PIT method was used as a method for preparing LNC in many studies [59][60][61][62] . Zhang et al 49 used PIT process to form milk-fat-based NLC for β-carotene delivery.…”

Section: Applications Of the Pit Methods To Another Lipid-based Nanocamentioning

confidence: 99%

Preparation of nanoemulsions by phase inversion temperature (PIT)

Jintapattanakit¹

2018

Pharm Sci Asia

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Section: Applications Of the Pit Methods To Another Lipid-based Nanocamentioning

confidence: 99%

Preparation of nanoemulsions by phase inversion temperature (PIT)

Jintapattanakit¹

2018

Pharm Sci Asia

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“…22 Recently, we proposed using fatty acids or monoglycerides as cosurfactants to obtain LNCs with antibacterial properties. 18 Monolaurin proved to be the most promising cosurfactant among all tested fatty acids and monoglycerides. Monolaurin-LNCs (ML-LNCs) exhibited the lowest minimum inhibitory concentration (MIC) or minimum bactericidal concentration (MBC) against two strains of S. aureus: one MSSA and one MRSA.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, they showed the lowest toxicity among the tested LNCs, with the bactericidal concentration being 32-or 64-fold higher than the hemolytic concentration. 18 The aim of the present work was to study the antibacterial activity of plectasin derivatives, AP114 and AP138, against seven MSSA and seven MRSA strains and to further investigate the antibacterial activity of ML-LNCs. To date, no studies have been performed to analyze the interactions between the peptides and ML-LNCs.…”

Section: Introductionmentioning

confidence: 99%

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Synergistic interactions between antimicrobial peptides derived from plectasin and lipid nanocapsules containing monolaurin as a cosurfactant against <em>Staphylococcus aureus</em>

Umerska¹,

Cassisa²,

Bastiat³

et al. 2017

IJN

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Development of effective antibacterial agents for the treatment of infections caused by Gram-positive bacteria resistant to existing antibiotics, such as methicillin-resistant Staphylococcus aureus (MRSA), is an area of intensive research. In this work, the antibacterial efficacy of two antimicrobial peptides derived from plectasin, AP114 and AP138, used alone and in combination with monolaurin-lipid nanocapsules (ML-LNCs) was evaluated. Several interesting findings emerged from the present study. First, ML-LNCs and both plectasin derivatives showed potent activity against all 14 tested strains of S. aureus , independent of their resistance phenotype. Both peptides displayed a considerable adsorption (33%–62%) onto ML-LNCs without having an important impact on the particle properties such as size. The combinations of peptide with ML-LNC displayed synergistic effect against S. aureus , as confirmed by two methods: checkerboard and time-kill assays. This synergistic interaction enables a dose reduction and consequently decreases the risk of toxicity and has the potential of minimizing the development of resistance. Together, these results suggest that ML-LNCs loaded with a plectasin derivative may be a very promising drug delivery system for further development as a novel antibacterial agent against S. aureus , including MRSA.

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“…Also, this membrane protects enteric bacterial cells from the action of detergents, amphiphilic compounds like the derivatives presented here. 64,65 For antitubercular activity a similar profile was observed, and compounds 2a-2c, 2e, 2f and 2o showed good to moderate activity, with MIC 90 ranging from 3.18 to 16.54 µg mL -1 . Previous studies have reported that the outer layer functions as an exclusion barrier for hydrophilic compounds, 66 and highly hydrophobic drugs are the most active antitubercular compounds because they could easily dissolve in the lipids of the outer cell wall layer and interact with bacterial amphiphilic surface.…”

Section: Resultsmentioning

confidence: 65%

Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol‑Based β-Amino Alcohol Derivatives

Manda

Prasad

Thatikonda

et al. 2017

J. Braz. Chem. Soc.

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The synthesis of novel amino alcohol derivatives based on cardanol and glycerol were achieved in good yields and characterized by 1 H and 13 C NMR (nuclear magnetic resonance) and MS (mass spectrometry). In addition, we evaluated the in vitro antimicrobial activity against Gram-positive (Staphylococcus aureus, standard and clinical strains), Gram-negative (Escherichia coli) and M. tuberculosis bacterial strains. The bioassay results indicated that four compounds showed activity against S. aureus, including the clinical resistant strain, with MIC (minimum inhibitory concentration) ranging from 3.90 to 15.60 µg mL -1 and M. tuberculosis, with MIC 90 (minimum inhibitory concentration required to inhibit the growth of 90% of organisms) ranging from 3.18 to 7.36 µg mL -1 .Keywords: CNSL, cardanol, amino alcohols, epoxide ring opening, antimicrobial activity IntroductionThe synthesis of fine chemicals from natural renewable resources has received great interest in synthetic community and is becoming a significant and challenging theme for researchers of both the academic and industrial sectors. Among the renewable materials, cardanol has attracted considerable attention due to its unique nature.1 Cardanol is a low cost, naturally occurring renewable non-isoprenoic phenolic lipid-mixture of cashew nut shell liquid (CNSL). The structural benefits of cardanol are carrying reactive phenolic group and hydrophobic alkyl/alkenyl side chain at meta-position of phenolic group. With these unique structural features, cardanol and its derivatives are renowned amphiphilic building blocks and precursors of high-value fine chemicals and supramolecular structures. Its derivatives present many biological activities such as: fungicidal, bactericidal, molluscicidal, larvicidal, anti-inflammatory, antioxidant and, towards serious disorders like cancer and obesity. [2][3][4][5][6][7][8][9] It is also described in the literature in recent years, that cardanol frameworks are involved to build phenolic resins, 10-12 bio-based polymers, 13 epoxy curing resins, 14-16 reactive diluents, 17,18 and fluorescent compounds. 19,20 Similarly, glycerol is another important renewable material used in the synthesis of higher value-added fine chemicals through green chemistry procedures in the last years. It may be applied, for instance, to generate hydrogen gas, 21 Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol-Based β-Amino Alcohol Derivatives J. Braz. Chem. Soc. 640 Cardanol and glycerol can be starting materials to prepare β-amino alcohols which is a vital interesting class of organic intermediates due to their abundant existence in nature and they are useful in the preparation of wide range of biologically active natural and synthetic frameworks, pharmaceuticals (e.g. β-blockers), unnatural β-amino acids, pesticides and chiral auxiliaries. [29][30][31][32] Additionally, β-amino alcohols have many applications as antibiotics, anti-bacterial drugs and, steroids.33 One of the most classical approaches toward the syn...

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Antibacterial action of lipid nanocapsules containing fatty acids or monoglycerides as co-surfactants

Cited by 54 publications

References 49 publications

Preparation of nanoemulsions by phase inversion temperature (PIT)

Preparation of nanoemulsions by phase inversion temperature (PIT)

Synergistic interactions between antimicrobial peptides derived from plectasin and lipid nanocapsules containing monolaurin as a cosurfactant against <em>Staphylococcus aureus</em>

Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol‑Based β-Amino Alcohol Derivatives

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