Antiapoptotic effect of DDB against hepatic ischemia-reperfusion injury

El-Bahy, Alshaymaa Amin Zaki; Kassem, Lobna; Heikal, Ola A.; Mahran, Laila

doi:10.2131/jts.36.145

Cited by 15 publications

(22 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, co-administration of DDB could restore the bone marrow nucleated cell count to the normal value (Hassanein et al, 2004). This effect may be interpreted on the basis that DDB administration decreases TNF-a and down-regulates expression of NF-kB (El-Bahy et al, 2011). The histopathological examination of the bone marrow of rats injected with LPS and treated with either of levamisole or DDB showed less adipoblastosis than those LPS injected alone, thus confirming the present results of the number of the nucleated bone marrow cells of these groups.…”

Section: Discussionsupporting

confidence: 88%

“…It accentuated the increase in the polymorphonuclear cells and the decrease in lymphocytes with no effect on monocytes. This result could be interpreted on the basis that levamisole as well as DDB may exert inhibitory effects on TNF-a secretion (Sun et al, 2007;El-Bahy et al, 2011;Kaya et al, 2011). Levamisole was found to enhance the immune response toward T helper 1 development by inducing IFN-c (Szeto et al, 2000).…”

Section: Discussionmentioning

confidence: 87%

“…The most plausible explanation for such improvement in the thymus weight as well as in the observed thymic histopathological findings among this levamisoletreated group is probably that levamisole may act by blocking thromboxane A2 formation (Pinto et al, 1990). The found improvement in the thymus weight as well in the histopathological findings of K pn LPS-injected and DDBtreated rats may be due to the inhibitory effect of DDB on the apoptotic pathway, which occurs either through inhibition of TNF-a and/or through its antioxidant activity (Qing and Liu, 1992;El-Bahy et al, 2011).…”

Section: Discussionmentioning

confidence: 89%

“…In addition, IFN-c can directly affect proliferation of hematopoietic progenitor cells and their differentiation toward myeloid cells (Yang et al, 2005). On the other hand, co-administration of DDB could restore the total white blood cells count and the bone marrow nucleated cell count to the normal range, the matter which may be interpreted by the fact that DDB administration decreased TNF-a and down-regulates expression of NF-kB (El-Bahy et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, DDB exerts potent antioxidant effect in normal and injured liver. It inhibits hepatic ischemia reperfusion injury (I/R)-induced apoptosis (El-Bahy et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Impact of certain immunomodulators on LPS-induced hematotoxicity

et al. 2015

View full text Add to dashboard Cite

The present study aimed to explore the extent to which immunomodulators may protect against Klebsiella pneumonia lipopolysaccharide (K pn LPS) toxicity. Two immunomodulators (levamisole and DDB) were utilized in the present work. The study was carried out on male Sprague Dawley rats, and animals were divided into four groups: One group was injected with saline intraperitoneally (i.p.) and served as a control group. The other three groups were subcutaneously daily injected with repetitive doses of K pn LPS (10, 10, 20, 20 and 40 lg/kg, i.p., for 5 consecutive days). Two of these K pn LPS-injected groups were daily cotreated with either levamisole (3 mg/kg, for 5 consecutive days, p.o) or DDB (6 mg/kg, for 5 consecutive days, p.o). At the end of the experiment, the effects of the given treatment were evaluated as regarding relative spleen and thymus weights, certain hematological changes (total and differential white blood cells count (WBCs), red blood cells count (RBCs), platelet count (PLAT), hemoglobin content (Hb), bone marrow cell count, as well as the histopathological changes in each of the spleen, thymus and bone marrow. The obtained results revealed that K pn LPS induced body weight loss, splenomegaly, thymic atrophy, leukopenia and lymphocytopenia. Each of bone marrow cells count and reticulocytes and eosinophil percentages were noticeably decreased after 5 days of K pn LPS administration. Each of the utilized drugs potentiated LPS-induced lymphocytopenia and increased segmented cells. However, DDB coadministration prior to K pn LPS injection could prevent the drop in bone marrow nucleated cells count, total WBCs, reticulocytes count and eosinophils differential count restoring them to their normal ranges. The histopathological examination of thymus, spleen and bone marrow of rats treated with either of the two utilized immunomodulators confirmed the above-mentioned results. Finally, the study reveals that DDB co-administration exerts more pronounced modulatory effect on LPS-induced hematotoxicity.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

“…In addition, DDB exerts potent antioxidant effect in normal and injured liver. It inhibits hepatic ischemia reperfusion injury (I/R)-induced apoptosis (El-Bahy et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations