Therapeutic effect of dimethyl dimethoxy biphenyl dicarboxylate on collagen-induced arthritis in rats

Talaat, Roba M.; Abo-El-Atta, Amira S.; Farou, Sabah M.; El-Dosoky, Karima I.

doi:10.1007/s11655-014-1746-1

Cited by 5 publications

(2 citation statements)

References 47 publications

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“…The CIA-induced animal model was employed for the present study, as CIA may alter cellular and humoral immunity and thus mimic the human RA condition. Previous studies have demonstrated that attenuation of the CIA-induced inflammatory process in rats is among the best methods to assess the anti-RA activity of a drug (24,25). Paw swelling (edema) and arthritis scores are the most important factors to consider when examining the anti-inflammatory and anti-arthritic properties of a drug (26).…”

Section: Discussionmentioning

confidence: 99%

Beneficial effect of 20-hydroxyecdysone exerted by modulating antioxidants and inflammatory cytokine levels in collagen-induced arthritis: A model for rheumatoid arthritis

Sun¹,

Zhao²,

Liu³

et al. 2017

Molecular Medicine Reports

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Rheumatoid arthritis is a chronic autoimmune disease characterized by an elevated synovial inflammatory response, with destruction or erosion of articular cartilage in major joints. The aim of the present study was to examine whether 20‑hydroxyecdysone (HES) is able to ameliorate oxidative stress and inflammatory responses in a collagen‑induced rheumatoid arthritis (CIA) rat model. A total of 40 healthy male rats were selected arbitrarily and separated into four groups. Rats treated with saline served as a control (group I), rats subjected to CIA induction by intradermal injection of bovine collagen II type served as the induced group (group II), while rats induced with CIA and administered with 10 and 20 mg/kg bodyweight HES for 28 days served as treatment groups (groups III and IV). Biochemical parameters, including paw swelling (edema), arthritis score, indexes of thymus and spleen, antioxidant levels (superoxide dismutase, catalase and glutathione), articular elastase and anti‑collagen II specific immunoglobulins (Ig)G, IgG1 and IgG2a, in addition to inflammatory markers [nitric oxide, C‑reactive protein, interleukin (IL)‑1β, IL‑6, tumor necrosis factor‑α and nuclear factor‑κB p65 subunit] were significantly decreased (P<0.01) following supplementation with HES (10/20 mg/kg). Consistently, the protein expression pattern of inducible nitric oxide synthase and cyclooxygenease‑2 were significantly downregulated (P<0.01) upon treatment with HES. In addition, histological analysis confirmed arthritis in CIA‑induced rats by revealing the presence of greater polymorphonuclear cell infiltration, with eroded articular cartilage and prominent synovitis. However, administration of HES was demonstrated to alleviate the morphological changes and maintain the normal architecture of synovial joints. In conclusion, the results of the present study indicated that treatment with HES (particularly 20 mg/kg) may effectively eradicate the inflammatory cascade and oxidative stress process in CIA‑induced rats and thereby exhibit anti‑rheumatoid arthritis properties.

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Section: Discussionmentioning

confidence: 99%

Beneficial effect of 20-hydroxyecdysone exerted by modulating antioxidants and inflammatory cytokine levels in collagen-induced arthritis: A model for rheumatoid arthritis

Sun¹,

Zhao²,

Liu³

et al. 2017

Molecular Medicine Reports

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“…On day 0, rats were injected intradermally at the tail base with 200 μL of a collagen‐II and IFA emulsion. Seven days after the initial immunization (day 0), rats received a booster injection on the other side of the tail with 100 μL of the emulsion to ensure a high incidence and severity of arthritis 58 . The CIA rats were then divided into 5 groups (groups 2‐6; 10 rats/group) as follows: group 2, CIA group without any treatment; group 3, MTX‐treated (rats received 4 intra‐peritoneal injections of MTX (1 mg/kg) as described by Hou et al 59 on days 11, 17, 24 and 31); and group 4, infliximab‐treated (rats were intravenously injected with 7 mg/kg as described by Smolen et al 60 on day 11).…”

Section: Methodsmentioning

confidence: 99%

Therapeutic potential of targeted‐gold nanospheres on collagen‐induced arthritis in rats

Shahen

Mohamed

Ali

et al. 2021

Clin Exp Pharma Physio

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Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes functional disability due to bone destruction and severe joint pain. Current anti‐rheumatic treatments develop severe complications and do not provide complete remission. Gold nanoparticles (AuNPs) have garnered attention because of their unique physical and chemical properties. In this study, we have evaluated the therapeutic effects of gold nanospheres (AuNSs) with two different ligands (targeted‐nanoparticles) against collagen‐induced arthritis (CIA) and compared the outcomes with conventional methotrexate (MTX) and biological (infliximab) treatments. Clinical evaluation was performed by radiographic and histological examinations. The bioaccumulation of AuNSs in vital organs was assessed. The mechanistic studies targeting pro‐inflammatory/anti‐inflammatory and angiogenic mediators’ expressions were performed. Radiographic examination showed that the targeted AuNSs reduced joint space narrowing and bone erosion. Moreover, histopathological examination of rat ankle joints demonstrated that targeted AuNSs reduce bone and cartilage degeneration/inflammation. Gold nanospheres‐conjugated with nucleus localized peptide (nuclear membrane‐targeted) (AuNSs@NLS) has resolved bone destruction and inflammation compared to gold nanospheres‐conjugated at polyethylene glycol (AuNSs@PEG). Although the AuNSs accumulated in different organs in both cases, they did not induce any toxicity or tissue damage. The two different targeted AuNSs significantly suppress inflammatory and angiogenic mediators’ expression and induced anti‐inflammatory cytokine production, but the AuNSs@NLS had superior therapeutic efficacy. In conclusion, these results suggested that nuclear membrane‐targeted AuNSs effectively attenuated arthritis progression without systemic side effects.

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Umbelliferone Ameliorates Complete Freund Adjuvant–Induced Arthritis via Reduction of NF-κB Signaling Pathway in Osteoclast Differentiation

et al. 2021

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Therapeutic effect of dimethyl dimethoxy biphenyl dicarboxylate on collagen-induced arthritis in rats

Abstract: Our data shed light on the therapeutic efficacy of DDB in experimental rheumatoid arthritis (RA) compared with a choice drug (MTX) and it may be offered as a second-line drug in the treatment of RA.

Cited by 5 publications

References 47 publications

Beneficial effect of 20-hydroxyecdysone exerted by modulating antioxidants and inflammatory cytokine levels in collagen-induced arthritis: A model for rheumatoid arthritis

Beneficial effect of 20-hydroxyecdysone exerted by modulating antioxidants and inflammatory cytokine levels in collagen-induced arthritis: A model for rheumatoid arthritis

Therapeutic potential of targeted‐gold nanospheres on collagen‐induced arthritis in rats

Umbelliferone Ameliorates Complete Freund Adjuvant–Induced Arthritis via Reduction of NF-κB Signaling Pathway in Osteoclast Differentiation

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