Antiangiogenic-targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatment

Fan, Chih‐Peng; Ting, Chien Yu; Liu, Hao Li; Huang, Chiung Yin; Hsieh, Han Yi; Yen, Tzu Chen; Wei, Kuo-Chen; Yeh, Chih Kuang

doi:10.1016/j.biomaterials.2012.11.048

Cited by 125 publications

(77 citation statements)

References 51 publications

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“…tUCA vs. non-tUCA for enhanced drug delivery Strikingly, when tUCAs for drug delivery are directly compared with their non-targeted UCA counterparts, tUCAs are more efficient both in vitro [184,185,188,189,192] (up to 7.7-fold higher [189]) and in vivo [186,187,190,191] (up to 5-fold higher [186]), regardless of whether the drug was coadministered with the tUCAs or whether the drug was loaded on/in the tUCAs. Although the reasons for this higher efficiency have not yet been investigated, several could be possible.…”

Section: Enhanced Drug Deliverymentioning

confidence: 99%

“…In vivo, the tUCAs were administered intraperitoneally allowing the tUCAs to adhere to the ovarian cancer cells. The other anti-cancer drug loaded into VEGFR2-tUCAs was BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) for the treatment of glioma brain tumours in vitro (1 MHz, 0.5 MPa, 10,000 cycles, PRF 5 Hz for 1 min treatment at two sites) and in vivo (1 MHz, 0.7 MPa, 10 ms burst, 5% duty cycle, PRF 5 Hz, 1 min treatment at two sites), where in vivo the tUCAs were also used to open the blood-brain barrier [191].…”

Section: Enhanced Drug Deliverymentioning

confidence: 99%

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Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy

Rooij

Daeichin

Skachkov

et al. 2015

International Journal of Hyperthermia

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Ultrasound contrast agents (UCAs) are used routinely in the clinic to enhance contrast in ultrasonography. More recently, UCAs have been functionalised by conjugating ligands to their surface to target specific biomarkers of a disease or a disease process. These targeted UCAs (tUCAs) are used for a wide range of pre-clinical applications including diagnosis, monitoring of drug treatment, and therapy. In this review, recent achievements with tUCAs in the field of molecular imaging, evaluation of therapy, drug delivery, and therapeutic applications are discussed. We present the different coating materials and aspects that have to be considered when manufacturing tUCAs. Next to tUCA design and the choice of ligands for specific biomarkers, additional techniques are discussed that are applied to improve binding of the tUCAs to their target and to quantify the strength of this bond. As imaging techniques rely on the specific behaviour of tUCAs in an ultrasound field, it is crucial to understand the characteristics of both free and adhered tUCAs. To image and quantify the adhered tUCAs, the state-of-the-art techniques used for ultrasound molecular imaging and quantification are presented. This review concludes with the potential of tUCAs for drug delivery and therapeutic applications.

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Section: Enhanced Drug Deliverymentioning

confidence: 99%

Section: Enhanced Drug Deliverymentioning

confidence: 99%

Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy

Rooij

Daeichin

Skachkov

et al. 2015

International Journal of Hyperthermia

View full text Add to dashboard Cite

show abstract

“…Designing a vehicle with these two opposing properties is one of the major challenge in the field of drug delivery [73][74][75]. Furthermore, the design of a triggering strategy able to change the vehicle from its stable yet circulating state to its unstable thus release state can be problematic [57,76].…”

Section: Ultrasound-triggered Drug Delivery Systemmentioning

confidence: 99%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

327

247

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• Ultrasound-based therapies are opening new horizons in the oncological field.• Innovative and promising solutions derive from different nanoparticles-assisted ultrasound treatments.• Sonodynamic therapy (SDT) emerged recently as a novel approach for cancer treatment.• Different and complex cell death mechanisms are involved in nanoparticles-assisted SDT.• Nanoparticles-assisted ultrasound is still at its infancy in clinics. A R T I C L E I N F O Keywords:Inertial cavitation Reactive oxygen species Sonoluminescence Sonodynamic Tumor Therapy Cytotoxicity A B S T R A C TAt present, ultrasound radiation is broadly employed in medicine for both diagnostic and therapeutic purposes at various frequencies and intensities. In this review article, we focus on therapeutically-active nanoparticles (NPs) when stimulated by ultrasound. We first introduce the different ultrasound-based therapies with special attention to the techniques involved in the oncological field, then we summarize the different NPs used, ranging from soft materials, like liposomes or micro/nano-bubbles, to metal and metal oxide NPs. We therefore focus on the sonodynamic therapy and on the possible working mechanisms under debate of NPs-assisted sonodynamic treatments. We support the idea that various, complex and synergistics physical-chemical processes take place during acoustic cavitation and NP activation. Different mechanisms are therefore responsible for the final cancer cell death and strongly depends not only on the type and structure of NPs or nanocarriers, but also on the way they interact with the ultrasonic pressure waves. We conclude with a brief overview of the clinical applications of the various ultrasound therapies and the related use of NPs-assisted ultrasound in clinics, showing that this very innovative and promising approach is however still at its infancy in the clinical cancer treatment.

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“…Micro-bubbles can be further modified with moieties designed to target tumor markers like VEGF, which one study reported could be used with USgFUS to prolong survival in rat glioma. 20 The experimental group had increased median survival compared with no treatment (42 days vs 19 days, p = 0.007) or BCNU alone (42 days vs 23 days, significance not reported). Notably, the nontargeted BCNUloaded microbubbles with FUS did not have a significant increase in median survival compared with no treatment.…”

Section: Ultrasound-guided Fusmentioning

confidence: 99%

A review of potential applications of MR-guided focused ultrasound for targeting brain tumor therapy

Lamsam¹,

Johnson²,

Connolly³

et al. 2018

Neurosurgical Focus

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Magnetic resonance–guided focused ultrasound (MRgFUS) has been used extensively to ablate brain tissue in movement disorders, such as essential tremor. At a lower energy, MRgFUS can disrupt the blood-brain barrier (BBB) to allow passage of drugs. This focal disruption of the BBB can target systemic medications to specific portions of the brain, such as for brain tumors. Current methods to bypass the BBB are invasive, as the BBB is relatively impermeable to systemically delivered antineoplastic agents. Multiple healthy and brain tumor animal models have suggested that MRgFUS disrupts the BBB and focally increases the concentration of systemically delivered antitumor chemotherapy, immunotherapy, and gene therapy. In animal tumor models, combining MRgFUS with systemic drug delivery increases median survival times and delays tumor progression. Liposomes, modified microbubbles, and magnetic nanoparticles, combined with MRgFUS, more effectively deliver chemotherapy to brain tumors. MRgFUS has great potential to enhance brain tumor drug delivery, while limiting treatment toxicity to the healthy brain.

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Antiangiogenic-targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatment

Cited by 125 publications

References 51 publications

Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy

Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

A review of potential applications of MR-guided focused ultrasound for targeting brain tumor therapy

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