Antiangiogenic activity of β-eudesmol in vitro and in vivo

Tsuneki, Hiroshi; Ma, Enlong; Kobayashi, Shogo; Sekizaki, Naoto; Maekawa, Kouji; Sasaoka, Toshiyasu; Wang, Minwei; Kimura, Ikuko

doi:10.1016/j.ejphar.2005.02.035

Cited by 126 publications

(92 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The intraperitoneal injection of b-eudesmol induced a marked reduction in angiogenesis than that of hydrocortisone ( Table 3). 21) b-Eudesmol inhibits tube formation (angiogenesis) of endothelial cells in the rat aorta (unpublished data). The antiangiogenic eŠect of b-eudesmol is greater than that of hydrocortisone ( Fig.…”

Section: Multidirectional Actions Of B-eudesmolmentioning

confidence: 87%

“…2(B)). 21) The blockade of extracellular signal-related kinase 1/2 by b-eudesmol may be the common mechanism for its antiangiogenic action. Therefore, b-eudesmol exhibits the following multiple pharmacological actions: 1) desensitization (channel blocking action) of nAChR, 2) antiangiogenic actions in the vascular endothelium, and 3) neuronal diŠerentiation induction (Fig.…”

Section: Multidirectional Actions Of B-eudesmolmentioning

confidence: 99%

“…The proliferation of porcine brain microvascular endothelial cells and human umbilical vein endothelial cells (HUVEC) is also inhibited by b-eudesmol. 21) It inhibits HUVEC migration stimulated by basicˆbroblast growth factor and tube The carmine content is an index of newly formed blood vessels in pouch granuloma. Data are means±S.E.M.n＝number of data.…”

Section: Multidirectional Actions Of B-eudesmolmentioning

confidence: 99%

See 2 more Smart Citations

Medical Benefits of Using Natural Compounds and Their Derivatives Having Multiple Pharmacological Actions

Kimura

2006

YAKUGAKU ZASSHI

Self Cite

View full text Add to dashboard Cite

The multiple pharmacological actions of a unique compound are a prerequisite for classifying drugs as highly e‹cacious, because the multiple pharmacological actions oŠer the possibility of treating various symptoms of chronic diseases as described below. 1) Sustained hyperglycemia induces macrovascular and microvascular complications in type 2 diabetes mellitus. Antihyperglycemic medication and the control of postprandial hyperglycemia are essentially important for normalizing plasma glucose level. Gymnemic acid IV isolated from Gymnema sylvestre (Asclepiadaceae) leaves has antisweet, antihyperglycemic, glucose uptake inhibitory, and gut glycosidase inhibitory eŠects. Most of these pharmacological eŠects may synergistically contribute to alleviating type 2 diabetes-related symptoms. 2) Diabetic skeletal and vascular smooth muscles are hypersensitive to chemical transmitters, cytokines and autacoids. The sensitivity of neuromuscular synapses is enhanced in diabetes, which seems to be closely associated with neuropathy as one of the diabetic complications. b-Eudesmol found in Atractylodes lancea rhizome has a desensitizing channel blocking action to nicotinic acetylcholine receptors, anti-angiogenic action in vascular endothelium, and neuronal diŠerentiation actions. These multiple pharmacological actions are favorable for treating angiogenic diseases possibly including the complications of diabetes, namely, retinopathy and nephropathy, and cancer. 3) Nipradilol is clinically utilized as a topical antiglaucoma drug. The ocular hypotensive eŠects of this compound are brought about by its a 1 -and b-adrenergic receptor blocking actions, and nitric oxide (NO) releasing action. NO directly activates cyclooxygenases. All these pharmacologic eŠects are beneˆcial for treating glaucoma. The selectivity and speciˆcity of drug action are required for treating acute diseases, infections or for acting as useful reagents. The pleiotropic actions of natural compounds and their derivatives serve as important clues for developing new drugs for various chronic diseases.

show abstract

Section: Multidirectional Actions Of B-eudesmolmentioning

confidence: 87%

Section: Multidirectional Actions Of B-eudesmolmentioning

confidence: 99%

Section: Multidirectional Actions Of B-eudesmolmentioning

confidence: 99%

See 1 more Smart Citation

Medical Benefits of Using Natural Compounds and Their Derivatives Having Multiple Pharmacological Actions

Kimura

2006

YAKUGAKU ZASSHI

Self Cite

View full text Add to dashboard Cite

show abstract

“…The latency to escape also showed a trend to decrease in Yueju-treated mice [13]. Many active components in Yueju are essential oils that may be extracted with ethanol, such as α-cyperone and β-cyperone in Xiang Fu and atractylin and hinesol in Cang Zhu [15], [29]. The effective components of Yueju regulate glutamate in a way similar to ketamine, and require further investigation.…”

Section: The Yueju Pillmentioning

confidence: 99%

Rapid-Acting Antidepressants and Underlying Mechanisms

Wilson¹,

Chen²,

Darji³

2016

IJPHS

View full text Add to dashboard Cite

Loss of glial cells with resulting atrophy of the medial prefrontal cortex (mPFC) as well as the hippocampal area is demonstrated in depressed patients by brain imaging and postmortem studies. The mPFC is the master control of mood and emotional response. The hippocampus is part of the limbic system, the main function of which is to regulate emotions. The mPFC depends on the hippocampus for rapid learning and memory consolidation. Unlike monoamine reuptake inhibitor antidepressants, which take 6 to 8 weeks to exert their full effects, and with 30-40% unresponsive rate, ketamine acts rapidly, within a couple of hours, and has higher responsive rates. It suggests that in theory, due to its rapid effect, Ketamine could well serve as a bridging remedy to lower the rate of suicidal risk before Selective serotonin re-uptake inhibitors (SSRIs) reach their full effect for long-term depression management. Yet, ketamine has long been linked with abusive potential and possible neurotoxicity if used in large doses over a prolonged period. Even though there are no collected data to prove the associated adverse effects, awareness of this negative aspect of ketamine is sufficiently widespread to propel the psychiatric community to look for other rapidly acting antidepressant alternatives. Recent studies have shown that scopolamine, the Yueju pill, and magnesium are rapid-onset antidepressants that have mechanisms comparable to that of ketamine. These rapid-acting antidepressant agents promise to be effective and safer choices for depression management in the future, providing for further studies and investigations to produce a better and fuller understanding of their effects and limitations.

show abstract

“…1 Phytochemical studies have shown that LAR is rich in sesquiterpene compounds. [2][3][4] Bioassays demonstrated that extracts/ sesquiterpene compounds from LAR have various pharmacological activities, such as anti-inflammatory, 3,5,6 antiulcer, [7][8][9] anti-lipid-peroxidation 10 and antitumor [11][12][13] activities. Apoptosis induction 14,15 and antiangiogenesis 16 have been implicated in the anticancer properties of one of the LAR sesquiterpenes-namely, atractylenolide І (AT-I).…”

Section: Introductionmentioning

confidence: 99%

Effects of Sesquiterpenes Isolated From Largehead Atractylodes Rhizome on Growth, Migration, and Differentiation of B16 Melanoma Cells

et al. 2010

View full text Add to dashboard Cite

The aims of this study were to isolate sesquiterpene compounds from the largehead atractylodes rhizome (LAR) and to investigate their effects on B16 cancer cells. A total of 8 sesquiterpenes from LAR were identified, of which eudesm-4 (15), 7-diene-9a, 11-diol (7) was isolated for the first time. All 8 compounds inhibited growth of B16 cells, and atractylenolide I (AT-I), atractylenolide II (AT-II), and atractylenolactam (ATR) were the most potent, with IC 50 values of 76.46, 84.02, and 54.88 mΜ, respectively. Monomer lactone or lactam structures in the 8 compounds appeared to be critical for their antiproliferative activities. In addition, AT-I, AT-II, and ATR could induce cell differentiation and inhibit cell migration. Western blot analysis indicated that 2 of the compounds, AT-I and AT-II, could inactivate ERK, where all 3 inhibited AKT activation, suggesting that Ras/ERK and PI3K/AKT signaling pathways are involved in the action mechanisms of the LAR sesquiterpene compounds.

show abstract

Antiangiogenic activity of β-eudesmol in vitro and in vivo

Cited by 126 publications

References 24 publications

Medical Benefits of Using Natural Compounds and Their Derivatives Having Multiple Pharmacological Actions

Medical Benefits of Using Natural Compounds and Their Derivatives Having Multiple Pharmacological Actions

Rapid-Acting Antidepressants and Underlying Mechanisms

Effects of Sesquiterpenes Isolated From Largehead Atractylodes Rhizome on Growth, Migration, and Differentiation of B16 Melanoma Cells

Contact Info

Product

Resources

About