Medical Benefits of Using Natural Compounds and Their Derivatives Having Multiple Pharmacological Actions

Kimura, Ikuko

doi:10.1248/yakushi.126.133

Cited by 56 publications

(23 citation statements)

References 39 publications

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“…For this reason, natural hypoglycaemic compounds present an attractive alternative to synthetic drugs or as reinforcements for currently used treatments (Kimura, 2006;Rout et al, 2009). This section presents some of the literature findings related to antidiabetic plant biomolecules, with particular emphasis on large classes of compounds that are easily available from many plant sources.…”

Section: B Natural Plant Biomolecules With Antidiabetic Actionmentioning

confidence: 99%

Plants and Natural Compounds with Antidiabetic Action

Coman

Rugină

Socaciu

2012

Not Bot Hort Agrobot Cluj

130

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Diabetes has become the most common metabolic disease worldwide. In particular, type 2 diabetes is the most commonly encountered type of diabetes, which is characterised by the inability of the organism to respond to normal levels of circulating insulin, also called insulin resistance. Current antidiabetic therapy is based on synthetic drugs that very often have side effects. For this reason, there is a continuous need to develop new and better pharmaceuticals as alternatives for the management and treatment of the disease. Natural hypoglycaemic compounds may be attractive alternatives to synthetic drugs or reinforcements to currently used treatments. Their huge advantage is that they can be ingested in everyday diet. Recently, more attention is being paid to the study of natural products as potential antidiabetics. This mini review of the current literature is structured into three main sections focused on: (a) plant extracts, (b) plant biomolecules, and (c) other natural molecules that have been used for their antidiabetic effects. Potential molecular mechanisms of action are also discussed.

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Section: B Natural Plant Biomolecules With Antidiabetic Actionmentioning

confidence: 99%

Plants and Natural Compounds with Antidiabetic Action

Coman

Rugină

Socaciu

2012

Not Bot Hort Agrobot Cluj

130

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“…Besides cancer, NO-donating compounds hold promise for the control of other diseases, including cardiovascular diseases [2], asthma [3], hypoxic-ischemic brain injury [4], glaucoma [5], and Alzheimer's disease [6]. To date, an extensive body of work including studies in preclinical models and relevant clinical trials underscores their therapeutic potential.…”

Section: Introductionmentioning

confidence: 99%

NO-donating NSAIDs and cancer: An overview with a note on whether NO is required for their action

Rigas

Williams

2008

Nitric Oxide

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Nitric oxide-donating nonsteroidal anti-inflammatory drugs (NO-NSAIDs) consist of a conventional NSAID to which an NO-releasing moiety is attached covalently, often via a spacer molecule. NONSAIDs represent an emerging class of compounds with chemopreventive properties against a variety of cancers, demonstrated in preclinical models including cell culture systems and animal tumor models; their potential efficacy in humans has not been assessed. Their mechanism of action appears complex and involves the generation of reactive oxygen species, suppression of microsatellite instability in mismatch repair-deficient cells, and modulation of several signaling cascades that culminate in inhibited cell renewal and enhanced apoptosis. NO, long appreciated to be able to protect from and also promote cancer, is released form NO-NSAIDs and constitutes their defining property. Existing data are consistent with the notion that NO may mediate their anticancer effect. In addition there is evidence that long term administration of NO-donating compounds is not associated with increased incidence of colon cancer. Whether NO release is required for the anticancer effect of NO-NSAIDs has being questioned by recent data indicating that, at least in the case of NO-aspirin, the NO-releasing moiety may serve as a leaving group while the spacer actually being the moiety responsible for its pharmacological action. Regardless of mechanistic issues, these compounds promise to contribute to the control of cancer.

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“…HS-PS and dexamethasone also significantly reduced the caspase-1 activity (p < 0.05). RIP-2 expression induces caspase-1 oligomerization, and promotes its activation (Kimura et al, 2006). Then, caspase-1 induces pro-inflammatory cytokine maturation (Galli et al, 2008).…”

Section: Docking Simulations Of the Components Of Kmp6 And Caspase-1 mentioning

confidence: 99%

Socioeconomic impact of traditional Korean medicine, Pyeongwee-San (KMP6) as an anti-allergic inflammatory drug

Song¹,

Nam²,

Choi³

et al. 2012

TANG [HUMANITAS MEDICINE]

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The prevalence of allergic disease has been increasing over the past few decades in the majority of Western industrialized nations. There are some socioeconomic disparities regarding allergic disease status and management. Pyeongwee-San (KMP6) is Korean medicine for the treatment of gastrointestinal tract disease. It is known that KMP6 has an improving effect on the spleen and stomach functions in traditional Korean medical theory. Here, we hypothesized that KMP6 could be used to regulate the inflammatory reaction. We show the molecular mechanisms of Pyeongwee-San (KMP6) on inflammatory reactions. A molecular docking simulation showed that hesperidin, component of KMP6, regulate the enzymatic activity by interaction in the active site of caspase-1. KMP6 control the activity of caspase-1 in activated human mast cell line (HMC-1 cells). KMP6 reduced the expression of receptor interacting protein (RIP)-2 in HMC-1 cells. Thymic stromal lymphopoietin protein production and mRNA expression were inhibited by KMP6. In the activated HMC-1 cells, KMP6 suppressed the activation of mitogen-ativated protein kinase and nuclear factor-kappaB. In addition, KMP6 significantly inhibited the expression of inflammatory cytokines. Our findings indicate that KMP6 may attenuate allergic reactions via the regulation of caspase-1/RIP-2 signaling pathway. These studies will help advance the social welfare system.

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Medical Benefits of Using Natural Compounds and Their Derivatives Having Multiple Pharmacological Actions

Cited by 56 publications

References 39 publications

Plants and Natural Compounds with Antidiabetic Action

Plants and Natural Compounds with Antidiabetic Action

NO-donating NSAIDs and cancer: An overview with a note on whether NO is required for their action

Socioeconomic impact of traditional Korean medicine, Pyeongwee-San (KMP6) as an anti-allergic inflammatory drug

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