Antiandrogene

Neumann, F.; Elger, W.; Steinbeck, H.; Berswordt-Wallrabe, R. von

doi:10.1007/978-3-642-51623-8_7

Cited by 16 publications

(6 citation statements)

References 93 publications

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“…no alveoli. That the glands reacted to hormo-The microscopic appearance of the small nal stimuli agrees with data from Neumann seminal vesicles does not seem to exclude et al (12), who, with the use of pituitary some influence of endogenous androgens ei- ther. To judge from the state of the secretory epithelium a further stimulation by exogenous Tp did not occur.…”

supporting

confidence: 55%

Reaction of Target Organs to Androgens in Feminized Rats

Forsberg¹,

Jacobsohn²

1971

Experimental Biology and Medicine

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supporting

confidence: 55%

Reaction of Target Organs to Androgens in Feminized Rats

Forsberg¹,

Jacobsohn²

1971

Experimental Biology and Medicine

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“…Hexestrol rather enhanced the androgen-target increasing effect of testosterone propionate. Therefore, these oestrogens are not to be classified as the anti-androgen in a strict sense as stated by Neumann et al (1968) who also pointed out the lack of anti-androgenicity in oestradiol-17ß (Neumann s von Berswordt-Wallrabe 1966). These results were assumed to be indicating that oestrogens manifest their apparent antiandrogenic effect only by mediating through the negative feed-back mechanism to inhibit gonadotrophin secretion and/or through a catabolic mechanism.…”

Section: As Shown Inmentioning

confidence: 99%

I. ANTI-ANDROGENIC EFFECTS OF a NEW STEROID TSAA-291 (16β-Ethyl-17β-Hydroxy-4-Oestren-3-One) AND ITS DERIVATIVES

Nakayama¹,

Masuoka²,

Masaki³

et al. 1979

Acta Endocrinologica

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Anti-androgenic properties of newly synthesized steroidal compounds, TSAA-291* and its derivatives, were studied in the rat.(1) Subcutaneous administrations of TSAA-291 and TSAA-272* were effective in depressing the weight of seminal vesicles and ventral and dorsal prostates in the adult rat.(2) TSAA-291, TSAA-328* and TSAA-272 were shown to be anti-androgenic by the subcutaneous or oral route in the immature castrated male rat treated with testosterone

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“…Many steroidal or nonsteroidal antiandrogens have been studied in adult rats, mice or chicken [39]: effects on fetal sex differentiation have rarely been explored, except for those of cyproterone acetate or some related compounds [39], I myself made a few unpublished observations with A-norprogesterone ( fig. 5), an antiandrogen studied by Dr. L. J.…”

Section: Antiandrogens With Particular Reference To Cyproterone Acetatementioning

confidence: 99%

Use of Androgen Antagonists and Antiandrogens in Studies on Sex Differentiation

Jost¹

1971

Gynecol Obstet Invest

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his review paper, including some unpublished results, summarizes some of the effects on sex differentiation in male fetuses of drugs which inhibit enzymes involved in steroid hormone synesis or of antiandrogens, especially cyproterone acetate. The former have only very slight effects on morphological sex differentiation. Cyproterone acetate is a very potent antimasculine agent in several species (rabbit, dog and probably others); in other species (rat, guinea pig, calf) the results obtained so far are at variance. Several apparently contradictory data pertaining to the stabilization and differentiation of the Wolffian ducts of the rat fetus are discussed.

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Antiandrogene

Cited by 16 publications

References 93 publications

Reaction of Target Organs to Androgens in Feminized Rats

Reaction of Target Organs to Androgens in Feminized Rats

I. ANTI-ANDROGENIC EFFECTS OF a NEW STEROID TSAA-291 (16β-Ethyl-17β-Hydroxy-4-Oestren-3-One) AND ITS DERIVATIVES

Use of Androgen Antagonists and Antiandrogens in Studies on Sex Differentiation

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