Antianaphylactic Effects of the Principal Compounds from the White Petals ofImpatiens balsaminaL.

Fukumoto, Hisae; Yamaki, Masae; Isoi, Koichiro; Ishiguro, Kyoko

doi:10.1002/(sici)1099-1573(199605)10:3<202::aid-ptr805>3.0.co;2-0

Cited by 36 publications

(28 citation statements)

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“…In some areas of Japan, juice squeezed from the white corolla of Impatiens balsamina is painted topically on the skin as an antipruritic to treat several types of dermatitis including urticaria, antianaphylactic (Ishiguro K et al, 1992;Ishiguro K et al, 1994;Fukumoto H et al, 1996); antihistamine (Fukumoto H et al, 1995); antipruritic Ishiguro K et al, 1998); anti-platelet-activating factor (Oku H et al, 1999); anti-dermatitic (Oku H et al, 2001). Traditionally, the dried herb is either boiled in water to make a tea used to treat systemic bacterial and fungal infections or applied directly on the skin or nails in a plaster form to treat local infections (Yang X et al, 2001).…”

Section: Traditional Usesmentioning

confidence: 99%

“…(Scheme 2: anti-anaphylactic effect after production of antibody) an extract (100mg/kg) or an isolated compound (10 mg/kg) from Impatiens balsamina was administered and HEL sensitized mice 1h before challenge with HEL on day 9. The time dependence of anti-anaphylactic effect of Impatiens balsamina after production of antibody in vivo assay Impatiens balsamina of 256 mg/kg (maximum dose possible) was administered intravenously 10, 30 and 60min before challenge (Fukumoto H et al, 1996; Ishiguro K et al, 1997). The anti-anaphylactic activities of a 35% EtOH extract of the flowers of Impatiens textori were investigated by in vivo assay.…”

Section: Antianaphylactic Activitymentioning

confidence: 99%

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Phytochemical and Pharmacological Significance of Genus: Impatiens

Singh¹,

Singh²,

Sati³

et al. 2017

IJLSSR

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ABSTRACT-The genus Impatiens (Compositae) was reviewed for its chemical constituents and biological significance and its traditional uses. The genus has been known for its various biological activities like: antimicrobial activity, antioxidant activity, antiallergic activity, antipruritic activity, antidermatitic activity, transcriptional activity, anti-rheumatoid arthritis activity, anti-histamine activity, testosterone 5α-reductase inhibitory activity, cyclooxygenase-2 inhibitory activity and anti platelet activating activity. Most of the plants of this genus are rich sources of napthoquinones, flanonoids, glycosides and sapogenins. The bioactive constituents or plants extracts may be uses for treatment of various diseases and these would be used as a new formulation for the novel drugs discovery in pharmaceutical industries. This review presents comprehensive information on the chemistry and pharmacology of the genus together with the traditional uses of many of its plants. In addition, this review discusses the structure-activity relationship of different compounds as well as recent developments and the scope for future research in this aspect.

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Section: Traditional Usesmentioning

confidence: 99%

Section: Antianaphylactic Activitymentioning

confidence: 99%

Phytochemical and Pharmacological Significance of Genus: Impatiens

Singh¹,

Singh²,

Sati³

et al. 2017

IJLSSR

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show abstract

“…4,5) Some of the antianaphylactic mechanisms of IB were also characterized using a blood pressure monitoring method, with administration of exogenous histamine 6) or platelet-activating factor (PAF).…”

Section: )mentioning

confidence: 99%

“…2) Hence, we investigated the participation of nitric oxide in mouse anaphylactic hypotension, 3) and the anti-anaphylactic effects of a 35% ethanol extract (IB) of white petals of Impatiens balsamina L., from which were isolated anti-anaphylactic compounds. 4,5) Some of the antianaphylactic mechanisms of IB were also characterized using a blood pressure monitoring method, with administration of exogenous histamine 6) or platelet-activating factor (PAF). 7) The mortality rate due to the shock of Hen egg-white lysozyme (HEL)-anaphylaxis is very high.…”

mentioning

confidence: 99%

Preventive Effects of Impatiens balsamina on the Hen Egg-White Lysozyme (HEL)-Induced Decrease in Blood Flow.

Ishiguro

Ohira

Oku

2002

Biological & Pharmaceutical Bulletin

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The search for anti-allergic substances from natural products has attracted much interest in recent years. Previously, we developed an in vivo assay system for quantitatively estimating mouse anaphylaxis, including fatal shock.1) The method of monitoring blood pressure in unanesthetized mice enabled us to study the dynamics of the anaphylactic response in the same individual animals without killing them. 2)Hence, we investigated the participation of nitric oxide in mouse anaphylactic hypotension, 3) and the anti-anaphylactic effects of a 35% ethanol extract (IB) of white petals of Impatiens balsamina L., from which were isolated anti-anaphylactic compounds. 4,5) Some of the antianaphylactic mechanisms of IB were also characterized using a blood pressure monitoring method, with administration of exogenous histamine 6) or platelet-activating factor (PAF). 7)The mortality rate due to the shock of Hen egg-white lysozyme (HEL)-anaphylaxis is very high. 1) Ohtsuka et al. 8) observed a decrease in the blood flow 30 min after an oral challenge with antigen in mouse intestine. This observation suggested that not only hypotension but also a decrease in the blood flow is involved in severe HEL-anaphylaxis, and thus led us to quantitatively determine anaphylaxis by blood flow. This paper describes the monitoring of blood flow as a reliable and useful method for quantitating murine anaphylaxis and evaluating the effects of I. balsamina. The results with currently used anti-allergic agents, diphenhydramine hy-disodium cromoglycate (DSCG) 10) and rac-3-(N-n-octadecylcarbamoyloxy)-2-methoxy-propyl 2-thiazoliethyl phosphate 11) are also reported. MATERIALS AND METHODS AnimalsMale ddY mice (SPF grade), 5 weeks old, were obtained from Japan SLC (Shizuoka, Japan) and housed at 24Ϯ2°C. Food and water were available ad libitum.Materials DPH was purchased from Nakalai Tesque; Ketanserin was from Funakoshi Co., Ltd.; DSCG was from Molecular Biology Resources, Inc.; CV-3988 was from Biomol Research Laboratories, Inc. These agents were dissolved in 10 ml saline/10 g body weight.Plant Materials and Extraction I. balsamina L. was planted in our medicinal plant garden and the white flowers were collected in August. Fresh flowers (2.5 kg) were freezedried (200 g), extracted with cold 35% EtOH for 24 h and concentrated in vacuo, giving a residue (designated IB) of 8.47 g. IB was dissolved in 10 ml saline/10 g body weight before use in biological experiments.Isolation of kaempferol 3-rutinoside (1) and lawsone (2-hydroxy-1,4-naphthoquinone) (2) from IB was done as previously reported.4) These compounds were dissolved in 100 ml saline/10 g body weight.HEL Sensitization and Challenge Immunization with HEL was performed as previously described.2) Male ddY mice, 5 weeks of age, were sensitized intraperitoneally (i.p.) on day 0 with 50 mg of HEL (Sigma, 6 times recrystallized) emulsified in Freund's complete adjuvant (DIFCO). On day 9, each mouse was challenged intravenously (i.v.) with 100 mg of HEL in 30 ml saline.Blood Flow Measurement Sub...

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“…Hence, we elucidated the participation of nitric oxide (NO) in mouse anaphylactic hypotension, 4) and the anti-anaphylactic effects of Impatiens balsamina L., from which anti-anaphylactic compounds have been isolated. 5,6) We also developed a more rapid assay systems using the blood pressure monitoring system. [7][8][9] Herein, we report that the blood flow of vein microcirculation is markedly decrease by HEL-sensitization alone without the HEL-challenge.…”

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confidence: 99%

Development of an in Vivo Bioassay Method for Allergy-Preventive Substances Using Hen-Egg White Lysozyme (HEL)-Induced Blood Flow Decrease

Ishiguro

Oku

Ueda

et al. 2005

Biological & Pharmaceutical Bulletin

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We discovered a phenomenon in which the blood flow in vein microcirculation markedly decreases in response to hen-egg white lysozyme (HEL)-sensitization without any change in blood pressure. Using this blood flow decrease as a guide, we developed an in vivo assay method to search for substances, which can prevent allergies. Antagonists of histamine, serotonin and platelet activating factor (PAF) did not affect the blood flow decrease in response to HEL-sensitization. On the other hand, cyclooxygenase (COX)-1, COX-2, thromboxane (TX) A 2 , endothelin-1 (ET-1), prostacyclin (PGI 2 ) and granulocytic elastase (GE) as well as nitric oxide (NO) from inducible NO synthase (iNOS) were involved in the blood flow decrease. Thus, these substances might injure vascular endothelial cells, and cause a decrease in blood flow in vein microcirculation. Our method can be used to search for preventive agents against allergies involving NO, COX-1, 2 and PGI 2 . This is the first report to applying to an assay method the specific blood flow decrease to occur in the promotion stage of allergy.

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Antianaphylactic Effects of the Principal Compounds from the White Petals ofImpatiens balsaminaL.

Cited by 36 publications

References 0 publications

Phytochemical and Pharmacological Significance of Genus: Impatiens

Phytochemical and Pharmacological Significance of Genus: Impatiens

Preventive Effects of Impatiens balsamina on the Hen Egg-White Lysozyme (HEL)-Induced Decrease in Blood Flow.

Development of an in Vivo Bioassay Method for Allergy-Preventive Substances Using Hen-Egg White Lysozyme (HEL)-Induced Blood Flow Decrease

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