Antiamoebic coumarins from the root bark of Adina cordifolia and their new thiosemicarbazone derivatives

A Decade of Development of Ethylidenethiosemicarbazides as Building Blocks for Synthesis of Azoles and Azines (A Review)

“…The biological activity of ethylidenethiosemicarbazides is related to their chelating ability with metal ion through either thione or thiolate sulfur and one of the hydrazone-nitrogen atoms 12 . Furthermore, ethylidenethiosemicarbazides have been used as a reactive building blocks for synthesis of different azoles such as, bis-thiazoles 13 , [1,3,4]thiadiazoles 14 , [1,3,4]oxadiazoles 15 , thiazolidin-4-ones 16 , imidazolinones 17 , and thiazoles 18,19 . In this survey, we represent three approaches about ethylidenethiosemicarbazides, with different aryl or heterocyclic moieties, including synthesis, reactivity, and their biological activities.…”

“…Recently, ethylidenethiosemicarbazides have been used as effective pharmacophoric agents in medicinal chemistry such as; antitumor 1 , anti-tubercular 2 , anti-amoebic 3 , anti-fungal 4 , antiviral 5 , antimicrobial 6 , antioxidant 7 , anticonvulsant 8 , and anti-trypanosomal 9,10 . Also, these compounds were prescribed for treatment of hypertension as calcium channel blockers 11 .…”

“…[4] 3,4-F 2 C 6 H 3 [25] [6] 4-BrC 6 H 4 [26] 3,4-Cl 2 C 6 H 3 [9] 4-CH 3 [ The reactivity of thiosemicarbazones 3 or 5 towards N-aryl carbohydrazonoyl chlorides 10, without keto group, has been reported 18,19,84 under thermal 19,84 or microwave irradiation and using grafted chitosan 18 or triethylamine 19,84 as basic catalyst. These reactions have been established to give [1,3,4]thiadiazoles11 (Scheme 4).…”

“…[4] 3,4-F 2 C 6 H 3 [25] [6] 4-BrC 6 H 4 [26] 3,4-Cl 2 C 6 H 3 [9] 4-CH 3 [ The reactivity of thiosemicarbazones 3 or 5 towards N-aryl carbohydrazonoyl chlorides 10, without keto group, has been reported 18,19,84 under thermal 19,84 or microwave irradiation and using grafted chitosan 18 or triethylamine 19,84 as basic catalyst. These reactions have been established to give [1,3,4]thiadiazoles11 (Scheme 4). Reaction with chloroethanoic acidor ethyl α α α α α-haloalkanoate Cyclocondensation of ethylidenehydrazine-1-carbothiamides3 or 5 with chloroethanoic acid (28) in ethanolic solution, containing anhydrous sodium acetate afforded thiazole-4(5H)-one derivatives 7,8,26,45,57,60 29 (Scheme 13).…”

Hepatoprotective activity of Adina cordifolia against ethanol induce hepatotoxicity in rats

“…of Adina cordifolia, having antiamoebic activity (Firdoos et al, 2009). According to ayurveda, the bark of this plant is used in liver disorders (Yoganarasimhan 1996).…”