A Decade of Development of Ethylidenethiosemicarbazides as Building Blocks for Synthesis of Azoles and Azines (A Review)

Abstract

This review represents the synthesis of ethylidenethiosemicarbazides, with aryl or heterocyclic moieties, and its utility as building blocks for construction of different heterocyclic compounds such as;

Antiproliferative Activity of (−)‐Isopulegol‐based 1,3‐Oxazine, 1,3‐Thiazine and 2,4‐Diaminopyrimidine Derivatives

“…[4] In addition, many synthetic compounds have 3-amino-1,2-diol moieties in their backbones, including the antitumor agent aminocyclopentitol pactamycin, the proteasome inhibitor TMC-95 A, the immunosuppressant antibiotic myriocin, riboflavin (vitamin B2) and the hydrogenase coenzyme F420. [5] Besides being of pharmacological interest, 3amino-1,2-diols have proven to be excellent building blocks for the synthesis of various heterocyclic compounds such as 1,3oxazine, [6,7] 1,3-thiazine [8] and pyrimidines. [9] Pyrimidines belong to an important class of heterocyclic structures found in many synthetic and naturally occurring products with a remarkable spectrum of biological activities.…”