Antiamoebic and spasmolytic activities of extracts from some antidiarrhoeal traditional preparations used in Kinshasa, Congo

Tona, L.; Kambu, K.; Ngimbi, N. P.; Mesia, K.; Penge, O; Lusakibanza, Mariano; Cimanga, K.; Bruyne, Tess De; Apers, Sandra; Totté, J.; Pieters, Luc; Vlietinck, A. J.

doi:10.1016/s0944-7113(00)80019-7

Cited by 163 publications

(120 citation statements)

References 22 publications

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“…Studies had revealed the anti-bacterial [15], anti-helminthic, antiretroviral [16], anti-plasmodial, anti-amoebic [17], anti-oxidant [18], sedative, anti-spasmodic, anti-fungal [19] and anti-malaria [14] activities of Euphorbia hirta. The plant has been reported to contain alkaloids, triterpenoids, phytosterols, tannins, polyphenols and flavonoids [13].…”

Section: Introductionmentioning

confidence: 99%

Toxicity Effects of Methanolic Extract of Euphorbia hirta-Honey Mixture in Albino Rats

Onyeka¹,

Сулейман²,

Bako³

2018

J Pharmacogn Nat Prod

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The Igbo people of the South-eastern part of Nigeria claims that a combination of Ehirta and honey has therapeutic effect for Ulcer. The study was designed to scientifically evaluate the phytochemical composition of E. hirta and the safety of the phytomedicine. Nine hundred gram (900 g) of E. hirta gave an average yield of 49.05 g of the extract and this gave percentage yield of 5.45% when extracted with continuous extraction process of Soxhlet apparatus. Phytochemical screenings of E. hirta showed that the extract contains alkaloids, Tannins, Saponins, Glycosides, Flavonoids and Unsaturated steroids. Acute toxicity studies showed that LD 50 was greater than 5000 mg/kg. The phytomedicine of E. hirta combined with did not produce significant changes in the blood biochemical and haematological parameters. Though slight reductions were witnessed in blood ALT the phytomedicine drugs has no significant effect on the liver and other vital organs like the kidney, the heart, spleen, intestine and the brain except the lungs that witnessed slight alveoli congestion. The study revealed that E. hirta combined with honey is safe for consumption.

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Section: Introductionmentioning

confidence: 99%

Toxicity Effects of Methanolic Extract of Euphorbia hirta-Honey Mixture in Albino Rats

Onyeka¹,

Сулейман²,

Bako³

2018

J Pharmacogn Nat Prod

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“…It is estimated that half of the world population is still at risk of contracting malaria and an Previously, a research program has been initiated by some of the authors for the evaluation of the antiamoebic and antiplasmodial activity of medicinal plants species traditionally used to treat amoebias and malaria in Congolese traditional medicine (Tona et al, 1998;Tona et al, 2000;Tona et al, 1999). (chloroquine resistant) strains of Plasmodium falciparum and the in vitro cytotoxicity of the same extracts against the human lungs fibroblasts WI-38.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo antimalarial and cytotoxic activity of five plants used in congolese traditional medicine

Lusakibanza

Mesia

Tona

et al. 2010

Journal of Ethnopharmacology

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Aim of the studyThe in vitro antiplasmodial activity and cytotoxicity of methanolic and dichloromethane extracts from five Congolese plants were evaluated. The plants were selected following an ethnobotanical survey conducted in D.R. Congo and focusing on plants used traditionally to treat malaria. The in vivo antimalarial activity of aqueous and methanolic extracts active in vitro was also determined in mice infected by Plasmodium berghei berghei. Materials and methodsThe growth inhibition of Plasmodium falciparum strains was evaluated using the measurement of lactate dehydrogenase activity. The extracts (aqueous, CH 3 OH, EtOH and CH 2 Cl 2 ) were prepared by maceration and tested in vitro against the 3D7 (chloroquine sensitive) and W2 (chloroquine resistant) strains of Plasmodium falciparum and against the human normal fetal lung fibroblasts WI-38 to determine the selectivity index. Some extracts were also used at the dose of 300mg/kg to evaluate their activity in mice infected since 4 days by Plasmodium berghei. ResultsTwo plants presented a very high activity (IC 50 < 3µg/ml). These plants were Strychnos icaja roots bark (MeOH and CH 2 Cl 2 ) and Physalis angulata leaves (MeOH and CH 2 Cl 2 ). One plant (Anisopappus chinensis whole plant, MeOH and CH 2 Cl 2 ) presented a high activity (IC50 < 15µg/ml).The extracts of Anisopappus chinensis and Physalis angulata showed also a good inhibition of parasitemia in vivo. Flavonoids, phenolic acids and terpenes were identified in these plants by a general phytochemical screening method. ConclusionThree plants showed a very interesting antiplasmodial activity (Anisopappus chinensis, Physalis angulata, Strychnos icaja) and one of them showed a good selectivity index ( >10, Anisopappus chinensis). Anisopappus chinensis and Physalis angulata were also active in vivo.

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“…At a concentration of 80 μg/ml in an organ bath, the extract exhibited more than 70% inhibition of acetylcholine and/or KCI -induced contractions on isolated guinea pig ileum. The growth of Entamoeba histolytica was inhibited by polyphenolic extract of the whole plant, the minimum active concentration was less than 10 pg/ml [105].…”

Section: Gastrointestinal Effectsmentioning

confidence: 92%

“…The antiplasmodial action of the extract was not related to the oxidation of red blood cell membrane lipids as increasing extract concentration results in the reduction of the enzymatic activities of SOD and GPx, and concentrations of GSH and TBARS [110]. The growth of Entamoeba histolytica was inhibited by polyphenolic extract of the whole plant, the minimum active concentration was less than 10 pg/ml [105]. Bioassay-guided fractionation of the methanolic extracts of Euphorbia hirta aerial parts led to the isolation of flavonol glycosides afzelin, quercitrin and myricitrin.…”

Section: Anti-parasitic Effectsmentioning

confidence: 99%

Pharmacology and therapeutic potential of Euphorbia hirta (Syn: Euphorbia pilulifera)- A review

Al-Snafi¹

2017

IOSRPHR

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Abstract:-The phytochemical screening of Euphorbia hirta revealed that the plant contained reducing sugars, terpenoids, alkaloids, steroids, tannins, proteins, fats, oils, gums, mucilages, glycoside, saponin, coumarin, cardiac glycosides, anthroquinones, flavanoids and phenolic compounds. The previous pharmacological studies showed that Euphorbia hirta exerted antioxidant, antimicrobial, sedative anxiolytic, antiepileptic, antiinflammatory, analgesic, antipyretic, antihistaminic, antiasthmatic, antidiabetic, anticancer, wound healing, gastrointestinal, diuretic, antiparasitic, immunological, hepatoprotective, galactogenic, angiotensin converting enzyme inhibiting and anti-dipsogenic activities. The current review discussed the chemical constituents, pharmacological and therapeutic potential of Euphorbia hirta.

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Antiamoebic and spasmolytic activities of extracts from some antidiarrhoeal traditional preparations used in Kinshasa, Congo

Cited by 163 publications

References 22 publications

Toxicity Effects of Methanolic Extract of Euphorbia hirta-Honey Mixture in Albino Rats

Toxicity Effects of Methanolic Extract of Euphorbia hirta-Honey Mixture in Albino Rats

In vitro and in vivo antimalarial and cytotoxic activity of five plants used in congolese traditional medicine

Pharmacology and therapeutic potential of Euphorbia hirta (Syn: Euphorbia pilulifera)- A review

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