Antiamnesic and Antioxidants Effects of Ferulago angulata Essential Oil Against Scopolamine-Induced Memory Impairment in Laboratory Rats

Hrițcu, Lucian; Bağcı, Eyüp; Aydin, Emel; Mihășan, Marius

doi:10.1007/s11064-015-1662-6

Cited by 34 publications

(29 citation statements)

References 41 publications

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“…Also, F. angulata extract attenuates oxidative stress in brain tissue in a rat model of Parkinson's disease (40). Essential oil of F. angulata has cognition-enhancing effect and improves scopolamine-induced memory impairment and oxidative stress (41). In the present study, F. angulata extract significantly ameliorated Aβ-induced neuronal cell death and attenuated Aβ-induced ROS production and oxidative stress.…”

Section: Discussionsupporting

confidence: 64%

Protective effects of Sanguisorba minor and Ferulago angulata total extracts against beta-amyloid induced cytotoxicity and oxidative stress in cultured cerebellar granule neurons

Akbari

Soodi

Hajimehdipoor

et al. 2019

J Herbmed Pharmacol

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Introduction: Alzheimer’s disease (AD) is an age-dependent neurodegenerative disorder and major cause of mortality in the elderly. AD has a complex pathophysiology and needs new multi-targeted compounds to halt the disease progression through several mechanisms. Medicinal plants contain various compounds with heterogeneous pharmacological effects, therefore are a good source. The aim of this study was to evaluate the protective effect of total extracts of Sanguisorba minor and Ferulago angulata on beta-amyloid (Aβ)-induced toxicity in primary neural cell culture.Methods: Cerebellar granule neurons (CGNs) were cultured according to standard protocols. The cultured neurons were incubated with Aβ alone or in combination with different concentrations of extracts for 24 hours. Cell viability was measured by methylthiazolyldiphenyl-tetrazolium (MTT) assay. In addition acetylcholinesterase (AChE) activity and oxidative stress markers were measured after incubation. Also, the effects of different concentrations of the extracts on AChE activity of the cultured neurons were investigated. For measuring the acute toxicity of the extract, LD50 was estimated by limit test.Results: Both extracts could protect CGNs against Aβ-induced cell death. Aβ-induced oxidative stress and increase of AChE activity were ameliorated by both extracts. S. minor extract dose-dependently reduced AChE activity in cultured CGNs. LD50 of both extracts was estimated above 2000 mg/kg and considered as safe.Conclusion: Both studied extracts protected CGNs against Aβ-induced toxicity by ameliorating oxidative stress mechanism. According to these results, these extracts are recommended for further investigation in AD treatment.

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Section: Discussionsupporting

confidence: 64%

Protective effects of Sanguisorba minor and Ferulago angulata total extracts against beta-amyloid induced cytotoxicity and oxidative stress in cultured cerebellar granule neurons

Akbari

Soodi

Hajimehdipoor

et al. 2019

J Herbmed Pharmacol

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“…In the present study, 10 days pretreatment of animals with D. integrifolia significantly counteracted the reduction of the percentage of spontaneous alternation induced by scopolamine suggesting significant improvement of space related short – term memory by the decoction of D. integrifolia ( Hritcu et al, 2012 , 2015 ; Beppe et al, 2014 ). The effect of D. integrifolia and that of tacrine a cholinesterase inhibitor used in the treatment of AD were comparables.…”

Section: Discussionsupporting

confidence: 59%

“…Our results with the MWM suggest that D. integrifolia improves spatial long-term memory ( Cheng et al, 2011 ). The results of MWM confirmed that pretreatment with D. integrifolia counteracted scopolamine induced learning and memory deficit thus D. integrifolia is neuroprotective ( Konar et al, 2011 ; Hritcu et al, 2015 ).…”

Section: Discussionsupporting

confidence: 54%

“…The results of biochemical assays show that 10 days administration of scopolamine increased the activity of AChE and the level of MDA, a measure of brain lipid peroxidation ( Hritcu et al, 2015 ) and reduced the level of GSH, the main antioxidant enzyme of the body ( Agarwal et al, 2011 ). Our results are in accordance with literature that shows that administration of scopolamine in rodents can lead to increase of AChE activity and oxidative status in the brain ( Cheng et al, 2011 ; Konar et al, 2011 ; Baradaran et al, 2012 ; Rajendran et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

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Nootropic and Neuroprotective Effects of Dichrocephala integrifolia on Scopolamine Mouse Model of Alzheimer’s Disease

et al. 2017

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Alzheimer’s disease the most common form of dementia in the elderly is a neurodegenerative disease that affects 44 millions of people worldwide. The first treatments against Alzheimer’s disease are acetylcholinesterase inhibitors; however, these medications are associated with many side effects. Dichrocephala integrifolia is a traditional herb widely used by indigenous population of Cameroon to treat and prevent Alzheimer’s disease and for memory improvement. In this study, we evaluated the effect of the decoction prepared from leaves of D. integrifolia, on scopolamine-induced memory impairment in mice. Seven groups of six animals were used. The first two groups received distilled water for the distilled water and scopolamine groups. The four test groups received one of the four doses of the decoction of the plant (35, 87.5, 175 or 350 mg/kg p.o.) and the positive control group received tacrine (10 mg/kg), a cholinesterase inhibitor used in the treatment of Alzheimer’s disease, during 10 consecutive days. Scopolamine (1 mg/kg), a cholinergic receptor blocker, administered 30 min after treatments, was used to induce memory impairment to all groups except the distilled water group on day 10 of drug treatment. The behavioral paradigms used to evaluate the effects of the treatment were the elevated plus maze for learning and memory, Y maze for spatial short-term memory, the novel object recognition for recognition memory and Morris water maze for the evaluation of spatial long-term memory. After behavioral tests, animals were sacrificed and brains of a subset were used for the assessment of some biomarkers of oxidative stress (malondialdehyde and reduced glutathione levels) and for the evaluation of the acetylcholinesterase activity. From the remaining subset brains, histopathological analysis was performed. The results of this study showed that, D. integrifolia at the doses of 87.5 and 350 mg/kg significantly (p < 0.01) improved spatial short-term and long-term memory, by increasing the percentage of spontaneous alternation in the Y maze and reducing the escape latency in the Morris water maze. Furthermore, the results of histopathological evaluation showed that D. integrifolia attenuated the neuronal death in the hippocampus induced by scopolamine. The main finding of this work is that D. integrifolia improves learning capacities and counteracts the memory impairment induced by scopolamine. Thus, D. integrifolia can be a promising plant resource for the management of Alzheimer’s disease and memory loss.

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“…For instance, different extracts and coumarins of the plant exerted moderate antiradical scavenging, antibacterial, and antioxidant activities . Moreover, in the literature antioxidant activity, in vivo anxiolytic and antidepressant for the EO, along with cytotoxicity, apoptosis‐inducing, and in vitro anticancer effects of the extracts were reported. Furthermore, the AcOEt and methanolic extract of F. angulata previously revealed the highest levels of phenolic compounds among its various extracts…”

Section: Introductionmentioning

confidence: 99%

Variation of Chemical Constituents and Antiradical Capacity of Nine Ferulago angulata Populations from Iran

Bagherifar

Sourestani

Zolfaghari

et al. 2019

Chemistry & Biodiversity

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The present study was designed to assess the influence of geographical factors on essential oil (EO) composition, along with antiradical potential and phytochemical contents of Ferulago angulata (Schltdl.) Boiss (Apiaceae) extracts for the first time. The aerial parts were hydrodistilled by Clevenger apparatus and subjected to gas chromatography coupled with flame ionization detector (GC/FID) and mass spectroscopy (GC/MS). The EO yields were significantly different from populations ‘Mongar’ (south‐slope, 3000 m) with 1.34±0.06 % and ‘Male‐Amiri’ (north slope, 2600 m) with 0.18±0.05 % of total oil. Thirty‐nine compounds were identified from the EOs of nine populations. α‐Pinene was the predominant component ranging from 20.84 to 49.06 % in ‘Gandomkar’ (north‐slope, 2500 m) and ‘Mongar’ (3000 m), respectively. The methanolic extract of ‘Mongar’ (north‐slope at 2500 m) possessed the highest total phenolic contents. Also, this population logically exhibited potent antiradical activity using both 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) and oxygen radical absorbance capacity (ORAC) assays with EC50 of 42.07±4.12 μg/mL and 8.34±0.21 mmol Trolox® equivalents/g, respectively. Due to its moderate free‐radical scavenging potential and high α‐pinene content, the population ‘Mongar’ might be considered as a perspective raw material in food and phytopharmaceutical industries.

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Antiamnesic and Antioxidants Effects of Ferulago angulata Essential Oil Against Scopolamine-Induced Memory Impairment in Laboratory Rats

Cited by 34 publications

References 41 publications

Protective effects of Sanguisorba minor and Ferulago angulata total extracts against beta-amyloid induced cytotoxicity and oxidative stress in cultured cerebellar granule neurons

Protective effects of Sanguisorba minor and Ferulago angulata total extracts against beta-amyloid induced cytotoxicity and oxidative stress in cultured cerebellar granule neurons

Nootropic and Neuroprotective Effects of Dichrocephala integrifolia on Scopolamine Mouse Model of Alzheimer’s Disease

Variation of Chemical Constituents and Antiradical Capacity of Nine Ferulago angulata Populations from Iran

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