As the main concern in sustainability is consideration to climatic conditions, climatically compatible design is the closest way of getting the maximum advantage of renewable sources of energy, while at the same time the design minimizes the undesirable effects of the construction in the environment and causes coordination with sustainability. From this point of view, the Bushehr traditional fabric, which is located in northern side of the Persian Gulf shore in south of Iran, is distinguished as a city with a unique vernacular architecture and climatically adapted urban design. Climatic design in Bushehr traditional city is seen in several characteristics including urban morphology and urban orientation, as well as architectural design and architectural elements of buildings such as Shenashir. The main reason of using all these solutions and strategies in vernacular architecture of Bushehr was to be adapted to climatic condition (a hot and humid climate) and therefore using the environmental potential to provide comfort for its occupants, which are the main purposes of sustainable development. As a result, this research attends to investigate these climatic solutions and their advantages as an idea to develop and use in contemporary architecture in order to reach sustainability. To this end, qualitative methodology based on a descriptive-interpretative approach is applied in this research for analyzing appropriate climatic solutions in vernacular architecture of Bushehr.
The present study aimed at assessing the influence of ecological factors on volatile oil content and antiradical potential of Prangos ferulacea. The essential oil (EO) content and composition of different plant parts were also compared. Among 22 identified compounds by gas chromatography (GC) flame ionization detector and GC-mass spectrometry, monoterpene hydrocarbons as the major constituents contributed to 27.6% to 83.4% of the oil deriving from plants growing on the northern steeps of "Gandomkar" region at 2600 m (G.N-2600) and "Male-Amiri" at 2300 m height (MA.N-2300), respectively. Immature seed and leaf samples of "Male-Amiri" with 3.0% ± 0.16% and 0.79% ± 0.03% of EO content represented the samples with the highest and lowest EO yields, respectively. Whereas the EO of the leaves mostly contained δ-3-carene and α-bisabolol, other parts were rich in αand β-pinene. Extracts of accessions "G.N-2600" (EC 50 = 13.11 ± 0.69 μg/mL) and "M.S-2500" (10.55 ± 0.41 mmol TE/g) exhibited the most potent antiradical activities in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and Oxygen Radical Absorbance Capacity (ORAC) assays, respectively. Because of the extensive use of this species in traditional foods and the remarkable bioactivities of αand β-pinene and δ-3-carene, the EO of the plant can be considered as a valuable raw material in phytopharmaceutical and food industries.
The present study was designed to assess the influence of geographical factors on essential oil (EO) composition, along with antiradical potential and phytochemical contents of Ferulago angulata (Schltdl.) Boiss (Apiaceae) extracts for the first time. The aerial parts were hydrodistilled by Clevenger apparatus and subjected to gas chromatography coupled with flame ionization detector (GC/FID) and mass spectroscopy (GC/MS). The EO yields were significantly different from populations ‘Mongar’ (south‐slope, 3000 m) with 1.34±0.06 % and ‘Male‐Amiri’ (north slope, 2600 m) with 0.18±0.05 % of total oil. Thirty‐nine compounds were identified from the EOs of nine populations. α‐Pinene was the predominant component ranging from 20.84 to 49.06 % in ‘Gandomkar’ (north‐slope, 2500 m) and ‘Mongar’ (3000 m), respectively. The methanolic extract of ‘Mongar’ (north‐slope at 2500 m) possessed the highest total phenolic contents. Also, this population logically exhibited potent antiradical activity using both 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) and oxygen radical absorbance capacity (ORAC) assays with EC50 of 42.07±4.12 μg/mL and 8.34±0.21 mmol Trolox® equivalents/g, respectively. Due to its moderate free‐radical scavenging potential and high α‐pinene content, the population ‘Mongar’ might be considered as a perspective raw material in food and phytopharmaceutical industries.
A multi-scale three-dimensional computational fluid dynamics (CFD) model was developed to predict airflow, heat and mass transfer in a typical full loaded cool storage. In order to reduce the computational costs, the porous media parameters of the bed of the apples inside the vented containers were extracted using a series of wind tunnel CFD simulations and then applied in the cool storage model. The model was validated against experiments by means of velocity, product temperature, and product weight loss measurements in cool storage. The errors of about 23.2 and 9.1% were achieved for velocity magnitude prediction in the cool storage and the product weight loss after 54 days of cooling in the loaded cool storage, respectively. The model over predicted the cooling rate of the products temperature; however, it showed a good trend of cooling rate. About 11°C difference was observed between the hottest and the coldest product temperatures at half cooling time by experiments that were in good agreement with the simulation results with about 10°C. This difference changes versus time of cooling and reached to about 4°C at the end of the cooling time. The product’s temperature heterogeneity was predicted 1.9°C between the 7 and 9 hours of cooling and reduced to 0.6°C at the end of the cooling. The multi-scale model was capable of predicting air velocity, product temperature, and weight loss with reasonable accuracy and was reliable enough for numerical studies on larger domain with high reduction in computational costs.
The genus Aeolothrips, with 17 recorded species, is the third most species-rich genus in Iran (Minaei 2013). In contrast, the genus Thrips includes 28 species in this country (Minaei 2012; Mirab-balou et al. 2012), and Haplothrips 24 species (Minaei & Aleosfoor 2013), Moreover, it seems likely that more species of Aeolothrips will be discovered in Iran, considering the number recorded from neighboring countries.
In this study, the effect of resistance and endurance training with/without ursolic acid supplementation was evaluated to identify atrophy‐related biomarkers in elderly rats induced by diabetes and a high‐fat diet (HFD) based on in silico analysis algorithms and pharmaceutical methods. The visualizer software found differential gene expression levels in skeletal muscle atrophy via computed hub gene network parameters. Also, the impact of ursolic acid, as a potent inducer of the Trp53 protein in ameliorating decreased muscle mass, was analyzed in diabetic rats. Fifty‐six‐old male Wistar rats were randomly assigned into seven groups, including healthy control (Control), diabetic control (DM), Ursolic acid supplementation (UA), resistance training (RT), endurance training (ET), resistance training+ Ursolic acid supplementation (RT + U), and endurance training in combination with Ursolic acid supplementation (ET + U). Exercise intervention included 8 weeks of resistance or endurance training programs. Biomedical informatic outputs determined the P53 signaling pathway as a remarkable causative factor in the pathomechanism of atrophy. In addition, the results demonstrated that exercise and supplementation of UA impeded the interactions among p53/ATF4/p21. Moreover, ET and ursolic acid had a synergetic effect on the signaling pathway of p53/ATF4/p21 and probably could inhibit the aging process and modulate the p53/ATF4/p21 molecular pathway. The interaction between UA and endurance exercise significantly modified the activity of the p53/ATF4/p21 signaling pathway. Based on in silico studies, the p53/ATF4/p21 pathway plays an essential role in aging, and the inhibition of this pathway would be beneficial in decelerating the aging process.
Practical applications
Ursolic acid (UA) is a natural pentacyclic triterpenoid carboxylic acid found in apples (a major compound of apple wax) and other fruits; it is known to improve skeletal muscle function and reduce the muscular atrophy pathways. We indicated that p53/ATF4/p21 signaling is an essential factor in aging, and the suppression of this pathway could be beneficial in the deceleration of the aging process. Therefore, this work would shed light on understanding the effect of exercise and nutrition interventions on preventing atrophy markers of skeletal muscle in diabetic rats. Further studies are needed to seek the precise mechanism of the synergism between UA and exercise in ameliorating atrophy markers.
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