Antiamnesic activity of amiridine on a model of the amnesic syndrome

Burov, Yu. V.; Robakidze, T. N.; Kadysheva, L. V.; Voronin, A. E.; Shaposhnikova, G. I.

doi:10.1007/bf00840189

Cited by 11 publications

(16 citation statements)

References 6 publications

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“…The improvement of working memory by these drugs reached the level of statistical significance during sessions 3-4 (Vp and tacrine) or 1-4 (amiridin), but did not progress with further training. The failure of complete reversal can be explained by irreversible changes in neuronal membranes (increased microviscosity and elevated cholesterol content) induced by chronic scopolamine treatment [4].…”

Section: Resultsmentioning

confidence: 99%

The effect of a new 9-aminoacridine derivative on working and long-term memory in rats

Sk¹,

Ts²,

Gt³

et al. 1999

Bull Exp Biol Med

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The effects of Vp, a new 9-aminoacridine derivative, on the radial maze performance of intact and scopolamine-treated rats were compared with those of amiridin and tacrine. In intact rats Vp improved the formation of long-term spatial memory and has a positive effect on working memory at the initial stage of training. In scopolamine-treated rats Vp reduced the amnesic effects of scopolamine on both kinds of memory.

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Section: Resultsmentioning

confidence: 99%

The effect of a new 9-aminoacridine derivative on working and long-term memory in rats

Sk¹,

Ts²,

Gt³

et al. 1999

Bull Exp Biol Med

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“…Recent studies showed the possibility of treating neurodegenerative diseases, including Alzheimer's disease (AD) with aminoacridine and tacrine derivatives [9,12,13]. The therapeutic effect of these drugs can be due to their neuroprotective activity manifested in inhibition of neuronal degeneration [4,15].…”

Section: Abstract: Aminoacridine Derivatives; Piracetam; Mechanorecementioning

confidence: 99%

Comparative analysis of neuroprotective activity of new chemical agent Vp and piracetam

Burov¹,

Uzdenskii²,

Robakidze

2000

Bull Exp Biol Med

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The effect of new agent Vp (9-butylamine-3,3-dimethyl-3,4-dihydroacridine-1(2H) hydrochloride) on lifetime of isolated mechanoreceptive crayfish neurons was evaluated by the duration of its impulse activity. Vp significantly and dose-dependently prolonged the lifetime of both spontaneously degrading neurons and neurons degrading under conditions of inhibition of various stages of the energy metabolism: glycolysis and oxidative phosphorylation. The effect of Vp in a concentration of 10(-7) M surpassed that of amiridine. Piracetam also prolonged the lifetime of spontaneously degrading neurons, but only in very high concentration (10(-2) M). It is concluded that Vp possesses a neuroprotective activity.

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“…Thus, a number of authors suppose that the pharmacological effects of the preparations are associated mainly with their anticholinesterase properties and with the blockade of potassium chan- nels of the nerve fiber [5,11]. It follows from our preceding studies [1,2] and from the investigations of foreign authors [7,12] that the antiamnestic activity of amiridin and tacrine is not associated with their capacity to inhibit acetylcholinesterase (ACE), but is determined by other mechanisms. The present study is a continuation of the study of the mechanisms of action of amiridin and tacrine.…”

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confidence: 94%

“…Amiridin is a new domestic preparation which has been effectively used in the treatment of cognitive disturbances, including senile dementia of the Alzheimer type (SDAT) [1,2], which is expressed in a progressive dementia [19]. Tacrine, which is similar in structure to amiridin [20], is widely used abroad in the clinical management of SDAT.…”

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confidence: 99%

Amiridin and tacrine modulation of the activity and plasticity of the cholinoreceptors of neurons of the common snail: Phenomenology and mechanisms

Burov

Drozdova

Pivovarov

et al. 1994

Neurosci Behav Physiol

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The influence of amiridin and tacrine on the membrane potential, activity, and plasticity of cholinoreceptors was investigated using the methods of recording of intracellular potentials and transmembrane currents in identified RPa3 and LPa3 neurons of the common snail. Amiridin and tacrine (1-100 mumole/liter) do not exert appreciable influences on the membrane potential of the cells. Both compounds modulate the activity of cholinoreceptors, judging from their influence on the inward current induced by local application of the acetylcholine: the duration of the ACh current increases and its amplitude varies biphasically (a short-latency increase is succeeded by a decrease). Amiridin and tacrine intensify the extinction of the ACh current induced by repeated applications of ACh to the soma. The acetylcholinesterase inhibitor, physostigmine, exerts a similar modulatory influence on the ACh current and on its extinction, and also prevents the manifestation of the effects of amiridin and tacrine. Amiridin and physostigmine directly influence the cholinoreceptors and the ionic membrane channels controlled by them by similarly altering the voltage-current characteristics (VAC) of the ACh current, and by shifting the reversal potential of the ACh current in the negative direction, bringing it closer to the equilibrium potential for chloride ions; this may be interpreted as a result of the nonidentical action of these compounds on the various ionic currents controlled by cholinoreceptors. The hypothesis is advanced that the modulatory influence of amiridin, tacrine, and physostigmine on the activity and plasticity of the cholinoreceptors is governed by their direct membrane-cytoplasmic action.

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Antiamnesic activity of amiridine on a model of the amnesic syndrome

Cited by 11 publications

References 6 publications

The effect of a new 9-aminoacridine derivative on working and long-term memory in rats

The effect of a new 9-aminoacridine derivative on working and long-term memory in rats

Comparative analysis of neuroprotective activity of new chemical agent Vp and piracetam

Amiridin and tacrine modulation of the activity and plasticity of the cholinoreceptors of neurons of the common snail: Phenomenology and mechanisms

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