Antiallergic Effects of ZCR-2060: Effect on Allergic Cutaneous Reactions and Rhinitis Models in Mice and Rats

Abstract

ABSTRACT-The antiallergic action of 2-[2-[4-(diphenylmethyl)-1-piperadinyl]ethoxy]benzoic acid maleate (ZCR-2060) was investigated on allergic cutaneous reactions and nasal vascular permeability in mice and rats. ZCR-2060 markedly inhibited immediate allergic cutaneous reactions, including passive cutaneous anaphylaxis (PCA) in rats and mice; histamine-, compound 48/80 and calcium ionophore A 23187-induced cutaneous reactions in rats; and biphasic skin reactions mediated by monoclonal IgE anti body and epicutaneous challenge with antigen in mice, but did not affect 5-hydroxytryptamine-induced cutaneous reaction in rats. The antigen-induced nasal vascular permeability increase in actively and passive ly sensitized rats and histamine-induced nasal vascular permeability increase in rats (allergic rhinitis model) were clearly inhibited in a dose-dependent fashion by ZCR-2060. Moreover, ZCR-2060 significantly inhib ited antigen-induced anaphylactic histamine release from rat peritoneal mast cells and carrageenin-induced paw edema in rats. These results suggest that ZCR-2060 has antiallergic effects on allergic cutaneous reac tions and experimental rhinitis, probably due to histamine H,-receptor blockage and the inhibition of histamine release.

Effects of Peppermint(Mentha piperita L.) Extracts on Experimental Allergic Rhinitis in Rats.

“…Antihistaminic, steroid and antiallergic drugs are used frequently as therapeutic drugs for treatment of allergic rhinitis. 5,6) On the other hand, systematic scientific studies have been also performed to examine the efficacy of traditional folk medicines and to isolate the biologically active compounds present in such medicines. 7) Mentha piperita L. has been reported to show anti-inflammatory, 8) antibacterial 9) and antifungal 10) activities.…”