Effects of propolis in an experimental rat model of allergic rhinitis

Yaşar, Mehmet; Savranlar, Yasemin; Karaman, Hati̇ce; Sağıt, Mustafa; Silici, Sibel; Özcan, İbrahim

doi:10.1016/j.amjoto.2016.03.007

Cited by 20 publications

(18 citation statements)

References 22 publications

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“…[22] Consistent with these observations, a study has reported that the administration of oral propolis 200 mg/kg in an ovalbumin-induced rat model of allergic rhinitis was lower; eosinophil count, vascular proliferation, ciliary loss, inflammation, and allergic rhinitis symptom score compared to ketotifen, furoate, and mometasone groups. [23] These results support the antiallergic activity of propolis.…”

Section: Immunomodulatory Effectsupporting

confidence: 64%

Immune's-boosting agent: Immunomodulation potentials of propolis

Al-Hariri

2019

J Fam Community Med

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With a concomitant increase in immune-related diseases such as allergic diseases, Type 1 diabetes mellitus, rheumatoid arthritis, multiple sclerosis, psoriasis, inflammatory bowel disease and other immune-related responses such as immunodeficiency, various infectious, diseases, vaccines, and malignancies, it has become very important to have a well-balanced and properly functioning immune system for the maintenance of human health. Recent scientific research has strongly suggested propolis as one of the most promising immunomodulation agents. This review describes recent findings with respect to propolis and its ingredients that show potential in this respect and evaluate their potential mechanisms. The author believes that propolis or/and its ingredients alone and in combination could be promising in manipulating the immune response and inducing immunomodulation. Further exploratory studies are needed to support large clinical trials toward further development of propolis.

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Section: Immunomodulatory Effectsupporting

confidence: 64%

Immune's-boosting agent: Immunomodulation potentials of propolis

Al-Hariri

2019

J Fam Community Med

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“…On the last day of the experiment, that is, Day 25, the blood and nasal tissue samples were collected after anesthesia for biochemical analysis. [ 35–37 ]…”

Section: Methodsmentioning

confidence: 99%

“…On the last day of the experiment, that is, Day 25, the blood and nasal tissue samples were collected after anesthesia for biochemical analysis. [35][36][37] 4.3 | Preparation of nasal mucosa tissue proteins Western blot analysis, and NF-κB DNA binding assay.…”

Section: Docking Analysis Of Cor In the Active Site Of Nf-ĸbmentioning

confidence: 99%

Protective effect of corynoline in a murine allergic rhinitis model via inhibition of caspase‐1/NF‐κB

Ren

Zhao

et al. 2020

Archiv der Pharmazie

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Allergic rhinitis (AR) is a serious public health concern worldwide. Therefore, the present study was conducted to scrutinize the protective effect of corynoline (COR) against ovalbumin (OVA)‐induced AR in BALB/c mice. The effect of COR was investigated on various parameters, such as nose‐rub score, histamine intensity, level of cytokines, and NF‐κB binding activity. It was found that COR causes a significant reduction in the nose‐rub score with a reduction in histamine intensity. It also causes reductions in cytokines, such as TNF‐α, IL‐1β, and MIP‐2, in comparison to OVA‐challenged mice. COR reduces the gene expression of active caspase‐1 in Western blot analysis, together with inhibition of NF‐κB binding activity. The inhibitory effect on NF‐κB binding was further substantiated by docking analysis, where COR excellently docked into the active site of NF‐κB via the creation of H‐bond and π–cation interactions with Lys145. Taken altogether, our results demonstrated that COR could be used as a potential therapeutic agent against AR.

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Section: Methodsmentioning

confidence: 99%

“…After a 10-min acclimatization period, nasal symptoms such as sneezing and rubbing were counted for 10 min by an observer blinded to experimental groups by placing each rat in an observation cage. 9 Histopathological Assessment. Rats were sacrificed by an overdose (100 mg/kg i.p., Sigma Chemical, St. Louis, MO) of sodium pentobarbital at 24 h after the last intranasal challenge.…”

Section: Assessment Of Nasal Symptoms In Sensitized Ratsmentioning

confidence: 99%

Effects of a Thermosensitive In Situ Gel Containing Mometasone Furoate on a Rat Allergic Rhinitis Model

Altuntaş

Yener

Doğan

et al. 2018

Am J Rhinol�Allergy

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Background Mometasone furoate, one of the second generation intranasal corticosteroids, is currently used in suspension form due to its poor solubility. However, this is not favorable for nasal application because of the rapid elimination of the instilled drug from the nasal cavity by mucociliary clearance and delayed onset of action due to the slow dissolution of drug in suspension. Objective The aim of this study was to determine the antiallergic effects of mucoadhesive thermosensitive in situ gel containing mometasone furoate that we developed previously to prolong the contact between the drug and nasal mucosa and to prevent drainage of the formulation in an ovalbumin-induced rat model of allergic rhinitis. Methods An experimental allergic rhinitis model was developed in female Wistar albino rats by intraperitoneal injection of ovalbumin every 2 days for 14 days followed by its repeated intranasal instillation for 7 consecutive days. Intranasal instillation of ovalbumin was continued every other day for 14 days. Mometasone furoate in situ gel (5 μg/10 µl), mometasone furoate suspension (5 μg/10 µl), and physiological saline (10 µl) were administered into the bilateral nasal cavities from day 22 to day 35. Antiallergic effects were evaluated through histopathological evaluation, analysis of ovalbumin-specific serum immunoglobulin E, and a symptom score. Results Mometasone furoate in situ gel significantly decreased the nasal symptoms and ovalbumin-specific serum immunoglobulin E level as compared with mometasone furoate suspension and physiological saline. Additionally, inflammatory histological symptoms such as mucosal edema, vascular dilatation, eosinophil infiltration, and loss of cilia within the nasal mucosa of allergic rhinitis model rats were remarkably improved with the treatment of mometasone furoate in situ gel. Conclusion These results suggest that mometasone furoate in situ gel has a better therapeutic potential for the treatment of allergic rhinitis compared to mometasone furoate suspension.

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Effects of propolis in an experimental rat model of allergic rhinitis

Cited by 20 publications

References 22 publications

Immune's-boosting agent: Immunomodulation potentials of propolis

Immune's-boosting agent: Immunomodulation potentials of propolis

Protective effect of corynoline in a murine allergic rhinitis model via inhibition of caspase‐1/NF‐κB

Effects of a Thermosensitive In Situ Gel Containing Mometasone Furoate on a Rat Allergic Rhinitis Model

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