Antiallergic Constituents from Oolong Tea Stem.

Ohmori, Yasuhiro; Ito, Mitsuaki; Kishi, Masataka; Mizutani, Hiroshi; Katada, Tomonori; Konishi, Hiroaki

doi:10.1248/bpb.18.683

Cited by 74 publications

(40 citation statements)

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“…It has been reported that some polyphenols could exert anti-allergic activities. [5][6][7][8][9][10] It is also known that tomato contains many polyphenols such as caffeic acid and rutin.…”

mentioning

confidence: 99%

Anti-allergic Activity of Naringenin Chalcone from a Tomato Skin Extract

Yamamoto¹,

Yoshimura²,

Yamaguchi³

et al. 2004

Bioscience, Biotechnology, and Biochemistry

149

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“…It has been reported that some polyphenols could exert anti-allergic activities. [5][6][7][8][9][10] It is also known that tomato contains many polyphenols such as caffeic acid and rutin.…”

mentioning

confidence: 99%

Anti-allergic Activity of Naringenin Chalcone from a Tomato Skin Extract

Yamamoto¹,

Yoshimura²,

Yamaguchi³

et al. 2004

Bioscience, Biotechnology, and Biochemistry

149

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“…conversely, omori et al reported that reishi reduced the renal disorder induced by CDDP (25). however, our study only had 3.5 day duration and the longer-term effect of MAK on injury to these organs needs to be established in further studies.…”

Section: Discussionmentioning

confidence: 66%

A water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia attenuates the small intestinal injury induced by anti-cancer drugs

Kashimoto¹,

Ishii²,

Myojin³

et al. 2010

Oncology Letters

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Abstract. the present study investigated whether a watersoluble extract from the culture medium of Ganoderma lucidum (reishi) mycelia (MAK) is able to protect the small intestine against damage induced by anti-cancer drugs. six-week-old male B6c3F1/crlj mice were fed a basal diet (MF) alone or with various doses of MAK or Agarics blazei Murrill (AgA) beginning one week before treatment with the anti-cancer drugs. Mice were sacrificed 3.5 days after injection of the anti-cancer drug, the small intestine was removed and tissue specimens were examined for the regeneration of small intestinal crypts. In experiment 1, the number of regenerative crypts after the administration of 5-fluorouracil (5FU) intravenously (250 mg/kg) or intraperitoneally (250 or 500 mg/kg) was compared after treatment with MAK or AGA. MAK protected against 5FU-induced small intestinal injury whereas AgA did not. In experiment 2, we investigated the protective effect of MAK against small intestinal injury induced by the anti-cancer drugs: UFT (tegafur with uracil; 1,000 mg/kg, orally), cisplatin (CDDP; 12.5 and 25 mg/ kg, intraperitoneally), cyclophosphamide (CPA; 250 mg/kg, orally) and gefitinib (Iressa; 2,000 and 4,000 mg/kg, orally). UFT and CDDP decreased the number of regenerative crypts, but treatment with MAK attenuated the extent of UFT-or cDDP-induced small intestinal injury. cPA or Iressa plus MAK up-regulated crypt regeneration. the present results indicate that MAK ameliorates the small intestinal injury caused by several anti-cancer drugs, suggesting that MAK is a potential preventive agent against this common adverse effect of chemotherapy.

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“…EGCG is known to inhibit immediate hypersensitivity reactions (38,45). We first compared in vivo effects on mast cell-dependent PCA reactions between different tea catechins, EGCG and its Omethylated derivatives (Fig.…”

Section: Effects Of Tea Catechins On Pca Reactionsmentioning

confidence: 99%

O-Methylated Catechins from Tea Leaves Inhibit Multiple Protein Kinases in Mast Cells

Maeda‐Yamamoto¹,

Inagaki

Kitaura

et al. 2004

The Journal of Immunology

118

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Tea contains a variety of bioactive compounds. In this study, we show that two O-methylated catechins, (-)-epigallocatechin-3-O-(3-O-methyl) gallate and (-)-epigallocatechin-3-O-(4-O-methyl) gallate, inhibit in vivo mast cell-dependent allergic reactions more potently than their nonmethylated form, (-)-epigallocatechin-3-O-gallate. Consistent with this, these O-methylated catechins inhibit IgE/Ag-induced activation of mouse mast cells: histamine release, leukotriene release, and cytokine production and secretion were all inhibited. As a molecular basis for the catechin-mediated inhibition of mast cell activation, Lyn, Syk, and Bruton’s tyrosine kinase, the protein tyrosine kinases, known to be critical for early activation events, are shown to be inhibited by the O-methylated catechins. In vitro kinase assays using purified proteins show that the O-methylated catechins can directly inhibit the above protein tyrosine kinases. These catechins inhibit IgE/Ag-induced calcium response as well as the activation of downstream serine/threonine kinases such as Akt and c-Jun N-terminal kinase. These observations for the first time have revealed the molecular mechanisms of antiallergic effects of tea-derived catechins.

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Antiallergic Constituents from Oolong Tea Stem.

Cited by 74 publications

References 0 publications

Anti-allergic Activity of Naringenin Chalcone from a Tomato Skin Extract

Anti-allergic Activity of Naringenin Chalcone from a Tomato Skin Extract

A water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia attenuates the small intestinal injury induced by anti-cancer drugs

O-Methylated Catechins from Tea Leaves Inhibit Multiple Protein Kinases in Mast Cells

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