Antiallergic and antihistaminic actions of Ceasalpinia bonducella seeds: Possible role in treatment of asthma

Vikhe, Sunayana; Nirmal, S. A.

doi:10.1016/j.jep.2017.12.007

Cited by 20 publications

(8 citation statements)

References 16 publications

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“…promote ongoing inflammatory conditions. [43] The present research work disclosed that both plants L. obovata and M. longifolia possess good anti-asthmatic potential, as this potential of both plants is also traditionally claimed. To the best of my information gathered, there is no published research work on the anti-asthmatic potential of L. obovata.…”

Section: Discussionmentioning

confidence: 58%

“…Eosinophilia is responsible for the shed off of the epithelial layer of airways, constriction of bronchi, and further spread of inflammation in the respiratory tract. [43] Eosinophil count in the blood can be used as a prognostic biomarker (in the prediction of asthma in advance) but not in the diagnosis as confirmed by the Global Initiative for Asthma. Leukocytosis (high white cell count of blood than normal) is a common characteristic of asthma.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the Anti-asthmatic Potential of Himalayan Plants Lonicera obovata Royle and Morina longifolia Wall: An in vivo Study

Boora¹,

Puri²,

Rani³

et al. 2023

Pharmacogn. Res.

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Background: Asthma is a very common and chronic disease in which there is an inflammation of the lungs. Inflammatory airways and narrowing, spasms, over-secretion of mucus, bronchoconstriction, and eosinophilic airway inflammation are generally seen in the asthmatic condition. Globally, its prevalence is rising constantly. The extracts of Lonicera obovata and Morina longifolia of the Caprifoliaceae family were traditionally used by the Himalayan local people to treat asthmatic and inflammatory conditions. Objectives: The goal of this experimental study was to identify the phytochemicals of the plants through GC-MS. To investigate and compare the anti-asthmatic potential of methanolic whole plant extracts of L. obovata and methanolic root extracts of M. longifolia through in-vivo experiments. Materials and Methods: The anti-asthmatic potential of extracts was determined by the method of leukocytosis and eosinophilia induced by milk in the Swiss albino mice model. Results: Various secondary active phytoconstituents were detected through the GC-MS screening method, some of which have anti-allergic (anti-asthmatic) and antihistaminic properties. The in vivo experiment result showed that in the case of increased leukocyte count, M. longifolia shows better results than L. obovata, and in the case of increased eosinophil count, L. obovata shows better results than M. longifolia to reduce the increased count. Conclusion:The anti-asthmatic potential of plant extracts could be due to the presence of the phytoconstituents like 1-Monolinoleoylglycerol trimethylsilyl ether in the L. obovata extracts and Octadec-9-enoic acid and Cis-vaccenic acid in both L. obovata and M. longifolia extracts. Hence, through the experiments, the unexplored anti-asthmatic properties were revealed and justifies the traditional usage of both plants to treat asthma.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Comparison of the Anti-asthmatic Potential of Himalayan Plants Lonicera obovata Royle and Morina longifolia Wall: An in vivo Study

Boora¹,

Puri²,

Rani³

et al. 2023

Pharmacogn. Res.

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“…The absorbance was measured spectrophotometrically at 517 nm. [8][9][10] The ability to scavenge DPPH radical was calculated using following formula:…”

Section: Determination Of Total Flavonoid Contentmentioning

confidence: 99%

“…The inflammation leads to bronchoconstriction, increased airway hyperresponsiveness, and mucus production. [6][7][8][9][10] Pharmacognostic study, physiochemical analysis, toxicity assessment, and evaluated and the extracts of this seeds have been used as an antipyretic activity. [11] In the present study was evaluated for phytochemical screening, mast cell stabilizing, anti-inflammatory, and antioxidant activity of the methanolic extract of Saraca Asoka for antiasthmatic potential has been carried out.…”

mentioning

confidence: 99%

Evaluation of Mast Cell Stabilizing, Anti-Inflammatory, and Anti-Oxidant Activity of Seed Extracts of Saraca Asoka (Roxb.), De. Wild

Ghante¹,

Rathod²

2022

APJHS

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Saraca Asoka (Caesalpiniaceae) is a medicinal plant used traditionally for the treatment of various diseases. There is no scientific evidence for the anti-asthmatic activity of Saraca Asoka. Preliminary phytochemical screening of extract has revealed the presence various phytochemical components such as flavonoids, tannins, saponins, carbohydrates, phenols, glycosides, and fixed oils and fats. However, no alkaloids, proteins and amino acids were found in the extracts. The present study was evaluated for phytochemical screening, mast cell stabilizing, anti-inflammatory, and antioxidant activity of the methanolic extract of Saraca Asoka. In the present study, DPPH radical scavenging activity was highest in methanol extract (94.5 % ± 1.8%) of Saraca Asoka seeds. The in vivo anti-inflammatory activity was evaluated in rats using carrageenan-induced paw edema and in vitro antioxidant activity was performed by 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) and ABTS. Quantitative estimation of total polyphenolic content of the (SA-ME) was estimated by Folin-Ciocalteu method. SA-ME (200 mg/kg body wt.) significantly decreased paw volume, after oral administration of SA-ME in carrageenan and formaldehyde injection. SA-ME also exhibit significant antioxidant activity. Total polyphenolic content was found to be (179 ± 0.27 mg/ml) and exhibited highest flavonoid content (8.42 ± 0.25 mg/ml). These results show that the methanol extract of Saraca Asoka seeds shows potential mast cell stabilizing, anti-inflammatory and anti-oxidant activity.

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“…The results implied that Hackberry oil is rich in valuable β-sitosterol. It is noteworthy that β-sitosterol is a common phytosterol recognized for its many good health effects such as an antipyretic and anti-inflammatory agent especially for the treatment of asthma 35,36) . In addition, it can contribute to the opposition of cholesterol absorption at intestine as well as prohibiting cancer (breast, colon and prostate) 37−39) .…”

Section: Phytosterolsmentioning

confidence: 99%

Chemical and Physical Characterization of the Hackberry (<i>Celtis australis</i>) Seed Oil: Analysis of Tocopherols, Sterols, ECN and Fatty Acid Methyl Esters

Nodeh¹,

Rashidi²,

Gabris

et al. 2020

J. Oleo Sci.

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IntroductionRecently, due to the increasing demand for fast foods and fatty diets in modern countries, it has become important to explore more nutritional and unsaturated edible oils from natural resources. Exploring and finding the edible oils containing high polyphenols, natural antioxidants, omega 3, 6 & 9, with less saturated fatty acid, are worth to health care. These needs have driven the governments to intensify their efforts in evaluating the nutritional values of available plants and the natural fortune of their territories 1) . Hence, various plant seeds/fruits have been studied in terms of its oil content, composition, nutritional values, oxidative stabilities, unsaturated factors, and edible or nonedible criteria. The well-known seeds/fruits oil resources that has been widely investigated includes sesame, olive, rapeseed, sunflower, soybean, corn, palm, and nuts and are widely used in preparation of food and other edible prod

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Antiallergic and antihistaminic actions of Ceasalpinia bonducella seeds: Possible role in treatment of asthma

Cited by 20 publications

References 16 publications

Comparison of the Anti-asthmatic Potential of Himalayan Plants Lonicera obovata Royle and Morina longifolia Wall: An in vivo Study

Comparison of the Anti-asthmatic Potential of Himalayan Plants Lonicera obovata Royle and Morina longifolia Wall: An in vivo Study

Evaluation of Mast Cell Stabilizing, Anti-Inflammatory, and Anti-Oxidant Activity of Seed Extracts of Saraca Asoka (Roxb.), De. Wild

Chemical and Physical Characterization of the Hackberry (<i>Celtis australis</i>) Seed Oil: Analysis of Tocopherols, Sterols, ECN and Fatty Acid Methyl Esters

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