Antiallergic activity profile in vitro of RHC 2963 and related compounds

Khandwala, Atul; Inwegen, Richard Van; Coutts, Stephen M.; Dally-Meade, Vernetta; Youssefyeh, R. D.

doi:10.1016/0192-0561(83)90042-5

Cited by 12 publications

(3 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 The main disadvantage of this class of drugs is its low effectiveness. 36 The novel, azobenzene-bridged, bis-chromone compounds MAC and PAC show an almost 100 times higher potency than the chromone drug DSCG based on β-hexosaminidase release assays ( Figure 3). This large increase in potency makes MAC and PAC interesting potential antiallergic agents, especially if the side effect pattern remains unchanged.…”

Section: ■ Discussionmentioning

confidence: 99%

“…The chromone-based drugs are an attractive and routinely used class of antiallergic agents because of their mast cell stabilizing capability and the limited side effects . The main disadvantage of this class of drugs is its low effectiveness . The novel, azobenzene-bridged, bis-chromone compounds MAC and PAC show an almost 100 times higher potency than the chromone drug DSCG based on β-hexosaminidase release assays (Figure ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Design, Synthesis, and Inhibitory Activity of Potent, Photoswitchable Mast Cell Activation Inhibitors

et al. 2013

View full text Add to dashboard Cite

Allergic reactions affect millions of people worldwide. The need for new and effective antiallergic agents is evident, and insight into the underlying mechanisms that lead to allergic events is necessary. Herein, we report the design, synthesis, and activity of photoswitchable mast cell activation inhibitors. In mast cell degranulation assays, these inhibitors possess significantly greater potency than an original, chromone-based antiallergic agent. Furthermore, one of the photoswitchable inhibitors shows a significant difference in inhibitory activity between its two photoisomeric forms. Further optimization could ultimately lead to a photoswitchable compound suitable for studying mechanisms involved in allergic reactions in a novel manner, with activity addressable by light and with precise spatiotemporal control over events at the molecular level.

show abstract

Section: ■ Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Design, Synthesis, and Inhibitory Activity of Potent, Photoswitchable Mast Cell Activation Inhibitors

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Numerous antioxidant and anti-inflammatory effects have been reported for Rosmarinic acid, [5][6][7] which may contribute to its anti-allergy activity. Rosmarinic acid has demonstrated free radical scavenging ability against superoxide anions and hydroxyl radicals.…”

Section: Rosmarinic Acid Displays Numerous Anti-inflammatory Effectsmentioning

confidence: 99%

Rosmarinic Acid as a Novel Agent in the Treatment of Allergies and Asthma*

Stansbury¹

2014

j restorat med

View full text Add to dashboard Cite

Rosmarinic acid, a caffeic acid ester and a component of several members of the Lamiaceae family including Rosmarinus officinalis, Perilla spp., and Salvia officinialis, has antioxidant and anti-inflammatory effects and is used for the treatment of asthma and reactive airway diseases, allergic disorders such as allergic rhinitis, otitis media, chemical sensitivity and multiple allergen reactivity. Rosmarinic acid can be used alone or in combination with other agents such as antioxidants, essential fatty acid supplements and other plant derived products. Rosmarinic acid can be administered orally and no adverse drug interactions have been reported. Nausea or mild stomach upset has been reported in sensitive patients in association with its oral intake and it is therefore recommended that Rosmarinic acid be ingested with food. Rosmarinic acid has shown free radical scavenging ability and suppression of allergic immunoglobulin and inflammatory responses of polymorphonuclear leukocytes, which may underlie its effectiveness in the treatment of allergic disorders, as demonstrated in clinical trials. Rosmarinic acid is a valuable agent for the treatment of allergic conditions, which is of importance considering the recent increase in the incidence of allergies, asthma and lung diseases associated with airborne pollutants.

show abstract

Biologically Active Thiophene Derivatives Revisited: 1983–1988

Press¹

1991

Chemistry of Heterocyclic Compounds: A Series of Monographs

View full text Add to dashboard Cite

Antiallergic activity profile in vitro of RHC 2963 and related compounds

Cited by 12 publications

References 33 publications

Design, Synthesis, and Inhibitory Activity of Potent, Photoswitchable Mast Cell Activation Inhibitors

Design, Synthesis, and Inhibitory Activity of Potent, Photoswitchable Mast Cell Activation Inhibitors

Rosmarinic Acid as a Novel Agent in the Treatment of Allergies and Asthma*

Biologically Active Thiophene Derivatives Revisited: 1983–1988

Contact Info

Product

Resources

About