Antiaging efficacy of melatonin-based day and night creams: a randomized, split-face, assessor-blinded proof-of-concept trial

Milani, Massimo; Sparavigna, Adele

doi:10.2147/ccid.s153905

Cited by 42 publications

(42 citation statements)

References 34 publications

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“…There is a wealth of literature on antioxidants and anti‐aging products, and multiple in vitro and in vivo studies of the effects of melatonin; however, very few published clinical studies have assessed the effects of a finished anti‐aging product containing melatonin. A recent study by Milani et al involving a twice‐daily regime of 0.1% melatonin‐based creams reported a significant reduction in crow's feet wrinkles of −15% on dermatologist clinical scoring assessment, but on instrumental assessment (profilometry) the differences did not reach statistical significance. The present study adds to this evidence of a clinical effect from melatonin‐based products, as we also found significant wrinkle reductions on clinical scoring (−5% at 1 month; −11% at study end) but in this case the differences also reached statistical significance on instrumental assessment, after just 1 month of use (Dermatop assessment).…”

Section: Discussionmentioning

confidence: 94%

“…Melatonin also acts synergistically with vitamins C and E, protecting against ultraviolet‐induced skin erythema . Despite substantial evidence on its antioxidant potential, few clinical studies have investigated its topical anti‐aging effects …”

Section: Introductionmentioning

confidence: 99%

“…5 Despite substantial evidence on its antioxidant potential, few clinical studies have investigated its topical anti-aging effects. 6 Bakuchiol, an extract of Psoralea corylifolia seeds, has been found to have similar efficacy to retinol, stimulating collagen in mature fibroblasts and upregulating genes involved in preserving the ECM and dermo-epidermal junction, 7 and decreasing wrinkles and hyperpigmentation in vivo, without the irritant side effects typical of retinol. 8 Ascorbyl tetraisopalmitate is a lipid-soluble vitamin C derivative with broader pH stability than ascorbic acid, 9 that is converted to ascorbic acid in the skin, where it provides an array of antioxidant actions.…”

mentioning

confidence: 99%

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Clinical evidence of the efficacy and safety of a new 3‐in‐1 anti‐aging topical night serum‐in‐oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days

Goldberg¹,

Robinson

Granger

2019

J of Cosmetic Dermatology

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Summary Background Topical melatonin is a potent antioxidant, yet there have been few clinical studies on its anti‐aging effects on the skin. Objectives To clinically assess the anti‐aging efficacy and safety of a new 3‐in‐1 night facial serum (NFS) combining melatonin with bakuchiol, a novel retinol‐like ingredient, and ascorbyl tetraisopalmitate, in all skin types. Methods Five clinical studies were performed, with a total of 103 subjects treated from 28 to 84 days. Under dermatologist supervision, a 3‐month efficacy and safety study evaluated anti‐aging properties by clinical scoring and instrumental evaluations. Two studies evaluated skin hydration properties for 12 hours after a single application of NFS. Two studies were performed in oily skin: a 1‐month efficacy and safety study and a 1‐month comedogenesis study. Results After 12 weeks, clinical evaluation showed a statistically significant decrease in wrinkles (11%), an increase in skin firmness (8%), a reduction in redness (70%; P < 0.01 for all), and an overall improvement in skin quality and complexion. The reduction in wrinkles and the increase in skin firmness were also supported by instrumental evaluations (Dermatop and Dynaskin). Hydration levels increased significantly from 30 minutes until 12 hours and transepidermal water loss significantly decreased after 4H and 6H. Subjects favorably evaluated the efficacy and cosmetic properties of the serum, and it was well tolerated in all skin types including oily skin. Conclusions This 3‐in‐1 NFS showed significant clinical anti‐aging effects when applied once daily and was well tolerated.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Clinical evidence of the efficacy and safety of a new 3‐in‐1 anti‐aging topical night serum‐in‐oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days

Goldberg¹,

Robinson

Granger

2019

J of Cosmetic Dermatology

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“…Additionally, melatonin has been used in cosmetic creams. For example, melatonin-based creams significantly improved skin tonicity and skin hydration in women, with a significant reduction in skin roughness, supporting the skin anti-aging effect of this molecule when applied topically [101]. Several cosmetic lines containing synthetic melatonin are marketed, but not containing phytomelatonin.…”

Section: Resultsmentioning

confidence: 93%

Development of a Phytomelatonin-Rich Extract from Cultured Plants with Excellent Biochemical and Functional Properties as an Alternative to Synthetic Melatonin

et al. 2020

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Melatonin is a pleiotropic molecule with multiple and various functions. In recent years, there has been a considerable increase in the consumption of melatonin supplements for reasons other than those related with sleep (as an antioxidant, for anti-aging, and as a hunger regulator). Although the chemical synthesis of melatonin has recently been improved, several unwanted by-products of the chemical reactions involved occur as contaminants. Phytomelatonin, melatonin of plant origin, was discovered in several plants in 1995, and the possibility of using raw plant material as a source to obtain dietary supplements rich in phytomelatonin instead of synthetic melatonin, with its corresponding chemical by-products was raised. This work characterizes the phytomelatonin-rich extract obtained from selected plant material and determines the contents in phytomelatonin, phenols, flavonoids, and carotenoids. Additionally, the antioxidant activity was measured. Finally, a melatonin-specific bioassay in fish was carried out to demonstrate the excellent biological properties of the natural phytomelatonin-rich extract obtained.Antioxidants 2020, 9, 158 2 of 18 melatonin in in vivo and in vitro experimental models have appeared [12,[20][21][22]. Thus, the roles of melatonin in many tumors, both in growth, proliferation, apoptosis, and metastasis have been demonstrated [23,24]. The treatments of melatonin with chemo-and radiotherapy improves the sensitivity of tumors to nonproliferation by drugs, acting as a synergistic molecule in the control of cancer cells. Additionally, melatonin mitigates acute damage in normal cells, protecting them against drug toxicity, possibly enhancing immunomodulation [25][26][27][28]. More recently, the use of electrophile-melatonin derivatives as chemopreventive agents on cancer cells has been demonstrated, calling them new "intelligent" molecules [29]. However, without a doubt, the most known and well-studied roles of melatonin are those related with sleep regulation and circadian rhythms. In this sense, melatonin is produced by the pineal gland in the night, increasing blood melatonin levels during the first period of sleep to around 150-220 pmoles/mL, acting on sleep initiation, reducing sleep latency and fragmentation and increasing sleep duration and sleep quality [30][31][32]. Additionally, melatonin, being a powerful chronobiological molecule that contributes to the correct circadian behavior of physiological functions, acts as an internal synchronizer of the circadian sleep-wake cycle and seasonal rhythmicity. In this sense, many sleep disorders have been treated with melatonin, including delayed sleep phase syndrome, night shift-work sleep disorder, seasonal affective disorder, sleep disorders in the blind and aging, and patho-physiological disorders of children, with notable improvements in sleep quality [9,[32][33][34][35][36]. The most widespread disorder treated with melatonin is jet-lag, a de-phasing in the sleep-wake rhythms following trans-oceanic flights [37][38][39].

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“…Topical application of Mel is considered meaningful, since it can easily penetrate the stratum corneum 14 . A recent clinical trial has shown that topical Mel improves clinical signs of skin aging 15 .…”

Section: Introductionmentioning

confidence: 99%

Anti-Aging Efficacy of Melatonin-Based Cream: Clinical and Instrumental Skin Evaluation

Milani¹,

Puviani²

2018

Preprint

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Background: Melatonin is a potent mitochondrial, cytoprotective and antioxidant molecule with potentially strong anti-aging properties. Topical melatonin has shown to improve the clinical signs of skin aging. Melatosphere™ is a new lipid-based delivery system able to improve stability and skin penetration of melatonin when used in topical formulations. No clinical studies, using objective instrumental data, are available so far regarding the positive effect of Melatosphere™ in improving wrinkles in women with mild-to-moderate skin aging. Study Aim: We evaluate, in an open prospective, evaluatorblinded trial, the effects on skin texture of 2 months treatment with a Melatosphere™ based cream. Subjects and Methods: 15 women aged >45 years with mild to moderate facial skin aging (Glogau score ≥2) participated in the trial, after their informed consent.An ANTERA 3D computer-assisted skin analysis evaluation for the assessment of coarse and fine wrinkles of the periorbital area and melanin content was performed at baseline and after two months of treatment. An evaluator-blinded Investigator Global assessment of skin elastosis, roughness, level of dyscromia, skin dryness and presence of actinic damage was also performed at the same time points using a 4-grade score from 0 (no sign) to 3 (severe sign). Results: At baseline the mean (SD) IGA score was 8.2(1.0). After 2 months the IGA score significantly decrease to 4.2(1.4) (49% reduction) (P=0.0007).ANTERA 3D evaluations showed a significant reduction in skin coarse and fine wrinkles volume in the target area of -31% and -18%, respectively. Melanin content was reduced significantly by -17%. Conclusion: Topical melatonin carried in Melatosphere improves in the short-term signs of skin aging evaluated clinically and by ANTERA 3D device in women with mild to moderate skin aging.

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Antiaging efficacy of melatonin-based day and night creams: a randomized, split-face, assessor-blinded proof-of-concept trial

Cited by 42 publications

References 34 publications

Clinical evidence of the efficacy and safety of a new 3‐in‐1 anti‐aging topical night serum‐in‐oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days

Clinical evidence of the efficacy and safety of a new 3‐in‐1 anti‐aging topical night serum‐in‐oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days

Development of a Phytomelatonin-Rich Extract from Cultured Plants with Excellent Biochemical and Functional Properties as an Alternative to Synthetic Melatonin

Anti-Aging Efficacy of Melatonin-Based Cream: Clinical and Instrumental Skin Evaluation

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